(Q36215755)

12 August 2017

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title

Transcriptional regulation and transformation by Myc proteins (English)

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12 August 2017

Martin Eilers

2

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author name string

Sovana Adhikary

series ordinal

1

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12 August 2017

1 August 2005

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Nature Reviews Molecular Cell Biology

12 August 2017

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12 August 2017

6

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12 August 2017

635-645

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12 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrm1703

12 August 2017

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cites work

Disentangling the MYC web.

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31 March 2020

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31 March 2020

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Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC

31 March 2020

1 reference

31 March 2020

The many faces of c-MYC.

1 reference

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

31 March 2020

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The MYC protein activates transcription of the alpha-prothymosin gene.

31 March 2020

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Reciprocal regulation of adipogenesis by Myc and C/EBP alpha

31 March 2020

1 reference

c-Myc enhances protein synthesis and cell size during B lymphocyte development

31 March 2020

1 reference

Drosophila myc regulates cellular growth during development.

31 March 2020

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c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression

31 March 2020

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c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

31 March 2020

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Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

31 March 2020

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Transient excess of MYC activity can elicit genomic instability and tumorigenesis

31 March 2020

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c-Myc regulates cyclin D-Cdk4 and -Cdk6 activity but affects cell cycle progression at multiple independent points

31 March 2020

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c-Myc regulates mammalian body size by controlling cell number but not cell size.

31 March 2020

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Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

31 March 2020

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N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation

31 March 2020

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

31 March 2020

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Negative regulation of the mammalian UV response by Myc through association with Miz-1

31 March 2020

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Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

31 March 2020

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Myc and Max associate in vivo

31 March 2020

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Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity

31 March 2020

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Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites.

31 March 2020

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Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

31 March 2020

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Binding of myc proteins to canonical and noncanonical DNA sequences

31 March 2020

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Sequence-specific DNA binding by the c-Myc protein

31 March 2020

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A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.

31 March 2020

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Oncogenic activity of the c-Myc protein requires dimerization with Max.

31 March 2020

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Analysis of Myc bound loci identified by CpG island arrays shows that Max is essential for Myc-dependent repression

31 March 2020

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X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors

31 March 2020

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Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation

31 March 2020

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Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis

31 March 2020

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Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth

31 March 2020

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Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation.

31 March 2020

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The Mad and Myc basic domains are functionally equivalent

31 March 2020

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Myc and Mad bHLHZ domains possess identical DNA-binding specificities but only partially overlapping functions in vivo

31 March 2020

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An alternative pathway for gene regulation by Myc

31 March 2020

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Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays

31 March 2020

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Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.

31 March 2020

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c-Myc target gene specificity is determined by a post-DNAbinding mechanism

31 March 2020

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A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells

31 March 2020

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Genomic targets of the human c-Myc protein

31 March 2020

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Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

31 March 2020

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Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network

31 March 2020

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Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.

31 March 2020

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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

31 March 2020

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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

31 March 2020

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Direct activation of RNA polymerase III transcription by c-Myc

31 March 2020

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MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

31 March 2020

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Werner syndrome protein limits MYC-induced cellular senescence

31 March 2020

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Repression of p15INK4b expression by Myc through association with Miz-1

31 March 2020

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TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

31 March 2020

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Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

31 March 2020

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Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage

31 March 2020

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c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism

31 March 2020

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Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3.

31 March 2020

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Direct role for Myc in transcription initiation mediated by interactions with TFII-I

31 March 2020

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Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc

31 March 2020

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p19ARF directly and differentially controls the functions of c-Myc independently of p53.

31 March 2020

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Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.

31 March 2020

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Functional analysis of the N-terminal domain of the Myc oncoprotein

31 March 2020

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A conserved element in Myc that negatively regulates its proapoptotic activity

31 March 2020

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Multiple cell-type-specific elements regulate Myc protein stability

31 March 2020

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Definition of regions in human c-myc that are involved in transformation and nuclear localization

31 March 2020

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The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

31 March 2020

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Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

31 March 2020

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31 March 2020

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The p400 complex is an essential E1A transformation target

31 March 2020

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Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions

31 March 2020

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A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin

31 March 2020

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An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc

31 March 2020

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Rvb1p/Rvb2p recruit Arp5p and assemble a functional Ino80 chromatin remodeling complex

31 March 2020

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Skp2 regulates Myc protein stability and activity

31 March 2020

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The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

31 March 2020

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Recruitment of a 19S proteasome subcomplex to an activated promoter

31 March 2020

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TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins

31 March 2020

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Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.

31 March 2020

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Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter

31 March 2020

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Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins

31 March 2020

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c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis

31 March 2020

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c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism

31 March 2020

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Developmental context determines latency of MYC-induced tumorigenesis

31 March 2020

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The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

31 March 2020

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The critical role of cyclin D2 in adult neurogenesis

31 March 2020

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Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors

31 March 2020

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Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

31 March 2020

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Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma

31 March 2020

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Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes

31 March 2020

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Mouse development and cell proliferation in the absence of D-cyclins.

31 March 2020

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Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues

31 March 2020

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Identification of CDK4 as a target of c-MYC.

31 March 2020

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Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

31 March 2020

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c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

31 March 2020

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

31 March 2020

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c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promoter

31 March 2020

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A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism

31 March 2020

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N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

31 March 2020

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Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc

31 March 2020

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Myc induces the nucleolin and BN51 genes: possible implications in ribosome biogenesis

31 March 2020

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Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes

31 March 2020

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Induction of cyclin E-cdk2 kinase activity, E2F-dependent transcription and cell growth by Myc are genetically separable events

31 March 2020

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Unlocking the potential of the human genome with RNA interference

31 March 2020

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The myc oncogene: MarvelouslY Complex

31 March 2020

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

31 March 2020

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Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes

31 March 2020

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Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts

31 March 2020

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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

31 March 2020

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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

31 March 2020

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Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization

31 March 2020

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A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size

31 March 2020

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

31 March 2020

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Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

31 March 2020

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Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis

31 March 2020

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Induction of apoptosis in fibroblasts by c-myc protein

31 March 2020

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Transcriptional and posttranscriptional control of c-myc during myogenesis: its mRNA remains inducible in differentiated cells and does not suppress the differentiated phenotype

31 March 2020

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

31 March 2020

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

31 March 2020

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Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

31 March 2020

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

31 March 2020

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Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

31 March 2020

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Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.

31 March 2020

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Myc requires distinct E2F activities to induce S phase and apoptosis

31 March 2020

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c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

31 March 2020

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Myc potentiates apoptosis by stimulating Bax activity at the mitochondria

31 March 2020

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Bim is a suppressor of Myc-induced mouse B cell leukemia

31 March 2020

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Apoptosis triggered by Myc-induced suppression of Bcl-X(L) or Bcl-2 is bypassed during lymphomagenesis

31 March 2020

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

31 March 2020

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

31 March 2020

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Overexpression of c-Myc alters G(1)/S arrest following ionizing radiation

31 March 2020

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c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

31 March 2020

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Defective double-strand DNA break repair and chromosomal translocations by MYC overexpression

31 March 2020

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Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations

31 March 2020

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Elevated presence of retrotransposons at sites of DNA double strand break repair in mouse models of metabolic oxidative stress and MYC-induced lymphoma

31 March 2020

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Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-Myc and transforming growth factor-alpha in the liver

31 March 2020

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Myc-Is this the oncogene from Hell?

31 March 2020

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c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations

31 March 2020

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Reversible tumorigenesis by MYC in hematopoietic lineages

31 March 2020

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MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

31 March 2020

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The ornithine decarboxylase gene is a transcriptional target of c-Myc

31 March 2020

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HMG-I/Y, a new c-Myc target gene and potential oncogene

31 March 2020

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Prothymosin alpha functions as a cellular oncoprotein by inducing transformation of rodent fibroblasts in vitro

31 March 2020

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Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis

31 March 2020

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Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

31 March 2020

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Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors

31 March 2020

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Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1703

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12 August 2017

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PubMed ID

16064138