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Immortalized cells as experimental models to study cancer.
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Europe PubMed Central
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3449965
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16 January 2020
title
Immortalized cells as experimental models to study cancer
(English)
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Europe PubMed Central
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3449965
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19003243%20AND%20SRC:MED&resulttype=core&format=json
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16 January 2020
author
Jesse S Boehm
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Europe PubMed Central
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3449965
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16 January 2020
William C Hahn
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William C Hahn
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Europe PubMed Central
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3449965
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16 January 2020
publication date
1 June 2004
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16 January 2020
published in
Cytotechnology
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3449965
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16 January 2020
volume
45
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Europe PubMed Central
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3449965
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16 January 2020
page(s)
47-59
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Europe PubMed Central
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3449965
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19003243%20AND%20SRC:MED&resulttype=core&format=json
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16 January 2020
issue
1-2
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Europe PubMed Central
PMCID
3449965
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16 January 2020
exact match
https://scigraph.springernature.com/pub.10.1007/s10616-004-5125-1
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Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts
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Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis
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Immortalization and transformation of primary human airway epithelial cells by gene transfer.
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INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence
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Enumeration of the simian virus 40 early region elements necessary for human cell transformation
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30 September 2017
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30 September 2017
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30 September 2017
Pot1, the putative telomere end-binding protein in fission yeast and humans
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30 September 2017
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
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30 September 2017
Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.
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30 September 2017
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.
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30 September 2017
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
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The Hallmarks of Cancer
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p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
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30 September 2017
Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse
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30 September 2017
Expression of catalytically active telomerase does not prevent premature senescence caused by overexpression of oncogenic Ha-Ras in normal human fibroblasts
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30 September 2017
Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
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30 September 2017
Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
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Inactivation of p16 in human mammary epithelial cells by CpG island methylation
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Extension of life-span by introduction of telomerase into normal human cells
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30 September 2017
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
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30 September 2017
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
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30 September 2017
A survey of telomerase activity in human cancer
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30 September 2017
Telomerase catalytic subunit homologs from fission yeast and human
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30 September 2017
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
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30 September 2017
Lessons from hereditary colorectal cancer
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30 September 2017
Human papillomavirus type 16 E7 alleviates a proliferation block in early passage human mammary epithelial cells
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30 September 2017
Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes
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30 September 2017
Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation
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30 September 2017
Developmental and tissue-specific regulation of mouse telomerase and telomere length
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30 September 2017
Oxidative DNA damage and senescence of human diploid fibroblast cells.
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30 September 2017
Specific association of human telomerase activity with immortal cells and cancer
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30 September 2017
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
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Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation
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The RNA component of human telomerase
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30 September 2017
Telomere length and replicative aging in human vascular tissues
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30 September 2017
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
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Origin of Concatemeric T7DNA
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30 September 2017
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
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30 September 2017
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
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30 September 2017
Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo
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30 September 2017
Activated v-myc and v-ras oncogenes do not transform normal human lymphocytes
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30 September 2017
Genetic alterations during colorectal-tumor development
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30 September 2017
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
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30 September 2017
Telomere reduction in human colorectal carcinoma and with ageing
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30 September 2017
Telomeres shorten during ageing of human fibroblasts
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
30 September 2017
Hypervariable ultra-long telomeres in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
30 September 2017
Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
30 September 2017
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
30 September 2017
Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
30 September 2017
Multiple stages of malignant transformation of human endothelial cells modelled by co-expression of telomerase reverse transcriptase, SV40 T antigen and oncogenic N-ras.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
29 June 2018
Human endothelial cell life extension by telomerase expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
29 June 2018
The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
29 June 2018
Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
29 June 2018
SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
29 June 2018
Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
29 June 2018
Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
29 June 2018
Control of protein phosphatase 2A by simian virus 40 small-t antigen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
29 June 2018
In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
29 June 2018
Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
22 September 2018
Reconstitution of telomerase activity combined with HPV-E7 expression allow human preadipocytes to preserve their differentiation capacity after immortalization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
22 September 2018
Telomerase maintains telomere structure in normal human cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
22 September 2018
RAS oncogenes: the first 30 years.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
22 September 2018
Transformation of normal human cells in the absence of telomerase activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
22 September 2018
CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
22 September 2018
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
22 September 2018
A genetically tractable model of human glioma formation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
22 September 2018
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3449965
retrieved
22 September 2018
Species- and cell type-specific requirements for cellular transformation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19003243
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cellular proteins that are targetted by DNA tumor viruses for transformation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19003243
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The SV40 small t antigen is essential for the morphological transformation of human fibroblasts
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19003243
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19003243
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A role for both RB and p53 in the regulation of human cellular senescence
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19003243
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19003243
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19003243
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Erosion of the telomeric single-strand overhang at replicative senescence
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19003243
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The tumor-suppressive functions of the human INK4A locus
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19003243
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1007/S10616-004-5125-1
1 reference
stated in
Europe PubMed Central
PMCID
3449965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19003243%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
PMCID
3449965
1 reference
stated in
Europe PubMed Central
PMCID
3449965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19003243%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
PubMed ID
19003243
1 reference
stated in
Europe PubMed Central
PMCID
3449965
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19003243%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
ResearchGate publication ID
23467690
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