(Q36313167)

13 August 2017

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title

Regulation of the Akt kinase by interacting proteins (English)

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13 August 2017

Keyong Du

1

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PubMed ID

16288287

13 August 2017

Philip N Tsichlis

series ordinal

2

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PubMed ID

16288287

13 August 2017

language of work or name

English

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publication date

1 November 2005

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13 August 2017

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13 August 2017

24

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13 August 2017

7401-7409

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13 August 2017

50

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209099

13 August 2017

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A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis

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7 January 2021

Anomalous expression of the HLA-DR alpha and beta chains in ovarian and other cancers

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A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

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PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

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7 January 2021

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function

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7 January 2021

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

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7 January 2021

Akt activation by growth factors is a multiple-step process: the role of the PH domain

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7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB.

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7 January 2021

SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia

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7 January 2021

The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton

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7 January 2021

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

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7 January 2021

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

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7 January 2021

Regulation of Akt/PKB activation by tyrosine phosphorylation

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7 January 2021

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

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7 January 2021

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

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7 January 2021

AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation

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7 January 2021

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle

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7 January 2021

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

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7 January 2021

Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 January 2021

A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane

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7 January 2021

TNFalpha-induced apoptosis and integrin switching in human extravillous trophoblast cell line

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Conformational changes associated with protein-protein interactions

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7 January 2021

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

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7 January 2021

Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations

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7 January 2021

A genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila.

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7 January 2021

Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes

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7 January 2021

Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1.

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7 January 2021

Crystal structure of an inactive Akt2 kinase domain

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

PKB/Akt interacts with inosine-5' monophosphate dehydrogenase through its pleckstrin homology domain.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Role for the adaptor protein Grb10 in the activation of Akt

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Interaction between Src and a C-terminal proline-rich motif of Akt is required for Akt activation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

JNK-interacting protein 1 promotes Akt1 activation.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction

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7 January 2021

Human tribbles, a protein family controlling mitogen-activated protein kinase cascades

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Altered gene expression pattern in the fatty liver dystrophy mouse reveals impaired insulin-mediated cytoskeleton dynamics

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

The protooncogene TCL1 is an Akt kinase coactivator

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Grb10: more than a simple adaptor protein

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Mediation of the DCC apoptotic signal by DIP13 alpha

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Identification of a novel kinase-like gene induced during neuronal cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Regulation of protein kinase B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

PDK1, the master regulator of AGC kinase signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Heat shock protein 90.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

The mitochondrial PHB complex: roles in mitochondrial respiratory complex assembly, ageing and degenerative disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Mouse NIPK interacts with ATF4 and affects its transcriptional activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Hsp90 and Cdc37 -- a chaperone cancer conspiracy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Kinase phosphorylation: Keeping it all in the family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Crystal structures of Tcl1 family oncoproteins and their conserved surface features.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Hsp90: chaperoning signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

The level of C/EBP protein is critical for cell migration during Drosophila oogenesis and is tightly controlled by regulated degradation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

A Xenopus tribbles orthologue is required for the progression of mitosis and for development of the nervous system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

The expression of keratin k10 in the basal layer of the epidermis inhibits cell proliferation and prevents skin tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Tribbles, a cell-cycle brake that coordinates proliferation and morphogenesis during Drosophila gastrulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Phosphorylation of serine 13 is required for the proper function of the Hsp90 co-chaperone, Cdc37.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Molecular advances in genetic skin diseases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Identification of myosin II as a binding protein to the PH domain of protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

The TCL1 family of oncoproteins: co-activators of transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Deregulated expression of TCL1 causes T cell leukemia in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Identification of the TCL1 gene involved in T-cell malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Requirement of the JIP1 scaffold protein for stress-induced JNK activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

SINK Is a p65-interacting Negative Regulator of NF-κB-dependent Transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Stimulated HSP90 binding to eNOS and activation of the PI3-Akt pathway contribute to globular adiponectin-induced NO production: vasorelaxation in response to globular adiponectin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

APPL suppresses androgen receptor transactivation via potentiating Akt activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

The JIP group of mitogen-activated protein kinase scaffold proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Ras GTPase-activating protein binds to Akt and is required for its activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209099

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209099

1 reference

13 August 2017

1 reference

PubMed ID

16288287