(Q36313171)

13 August 2017

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title

The Akt of translational control (English)

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13 August 2017

2

Nahum Sonenberg

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13 August 2017

Davide Ruggero

1

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PubMed ID

16288289

13 August 2017

language of work or name

English

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publication date

1 November 2005

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13 August 2017

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13 August 2017

24

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13 August 2017

7426-7434

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13 August 2017

50

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209098

13 August 2017

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cites work

Perturbations of the AKT signaling pathway in human cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

The TOR pathway: a target for cancer therapy

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune response in squamous cell lung carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Control of p70 s6 kinase by kinase activity of FRAP in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Translational control: the cancer connection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

eIF4E expression in tumors: its possible role in progression of malignancies

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Pten is essential for embryonic development and tumour suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

What has senescence got to do with cancer?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Assembly of 48S translation initiation complexes from purified components with mRNAs that have some base pairing within their 5' untranslated regions.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Decreased proliferation of human melanoma cell lines caused by antisense RNA against translation factor eIF-4A1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cellsin vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Regulation of translation initiation by FRAP/mTOR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

An expanding role for mTOR in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Mitogenic and nutritional signals are transduced into translational efficiency of TOP mRNAs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Overexpression of human insulin receptor substrate 1 induces cellular transformation with activation of mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Tor signalling in bugs, brain and brawn

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: implications for tumor angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Unmasking a growth factor/oncogene-activated S6 phosphorylation cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Ras mediates translation initiation factor 4E-induced malignant transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Transcription inhibitors stimulate translation of 5' TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Modulation of transcription of rRNA genes by rapamycin

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

eIF4E--from translation to transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Germline mutations in PTEN are present in Bannayan-Zonana syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Oncogenic transformation induced by membrane-targeted Akt2 and Akt3.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Drosophila S6 kinase: a regulator of cell size.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Phosphorylation of ribosomal protein S6. Relationship to protein synthesis in HeLa cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Role of pescadillo and upstream binding factor in the proliferation and differentiation of murine myeloid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Suppression of cap-dependent translation in mitosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Regulation of cap-dependent translation by eIF4E inhibitory proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

eIF4A: the godfather of the DEAD box helicases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Expression of eukaryotic translation initiation factors 4E and 2alpha is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Does the ribosome translate cancer?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

mTOR and P70 S6 kinase expression in primary liver neoplasms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

The biology and clinical relevance of the PTEN tumor suppressor pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Autocrine transforming growth factor alpha regulates cell adhesion by multiple signaling via specific phosphorylation sites of p70S6 kinase in colon cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Will mTOR inhibitors make it as cancer drugs?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Akt/protein kinase B promotes organ growth in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Detection of eIF4E gene amplification in breast cancer by competitive PCR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Competitive PCR to detect eIF4E gene amplification in head and neck cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Progressive amplification and overexpression of the eukaryotic initiation factor 4E gene in different zones of head and neck cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Pattern of amplification and overexpression of the eukaryotic initiation factor 4E gene in solid tumor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Phosphoinositide 3-kinases as drug targets in cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Functional significance of S6K overexpression in meningioma progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

IGF-I receptor signalling in transformation and differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209098

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209098

1 reference

13 August 2017

1 reference

PubMed ID

16288289