(Q36362268)

English

Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity

scientific article

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scholarly article

1 reference

Europe PubMed Central

13 August 2017

Somatic variation precedes extensive diversification of germline sequences and combinatorial joining in the evolution of immunoglobulin heavy chain diversity (English)

1 reference

Europe PubMed Central

13 August 2017

author name string

Hinds-Frey KR

1

1 reference

Europe PubMed Central

13 August 2017

Nishikata H

2

1 reference

Europe PubMed Central

13 August 2017

Litman RT

3

1 reference

Europe PubMed Central

13 August 2017

Litman GW

4

1 reference

Europe PubMed Central

13 August 2017

language of work or name

0 references

publication date

1 September 1993

1 reference

Europe PubMed Central

13 August 2017

Journal of Experimental Medicine

1 reference

Europe PubMed Central

13 August 2017

178

1 reference

Europe PubMed Central

13 August 2017

815-824

1 reference

Europe PubMed Central

13 August 2017

3

1 reference

Europe PubMed Central

13 August 2017

Somatic generation of antibody diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Antibody diversity: somatic hypermutation of rearranged VH genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Immunoglobulin VH gene structure and diversity in Heterodontus, a phylogenetically primitive shark

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Extensive families of constant region genes in a phylogenetically primitive vertebrate indicate an additional level of immunoglobulin complexity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Organization of human immunoglobulin heavy chain diversity gene loci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Diverse organization of immunoglobulin VH gene loci in a primitive vertebrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Complete structure and organization of immunoglobulin heavy chain constant region genes in a phylogenetically primitive vertebrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Mechanism and developmental program of immunoglobulin gene rearrangement in mammals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Genomic organization and sequences of immunoglobulin light chain genes in a primitive vertebrate suggest coevolution of immunoglobulin gene organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Evolution of immunoglobulin genes: VH families in the amphibian Xenopus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Evolutionary comparison of the avian IgL locus: combinatorial diversity plays a role in the generation of the antibody repertoire in some avian species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Two distinct immunoglobulin heavy chain isotypes in a primitive, cartilaginous fish, Raja erinacea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Eleven distinct VH gene families and additional patterns of sequence variation suggest a high degree of immunoglobulin gene complexity in a lower vertebrate, Xenopus laevis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Intraclonal generation of antibody mutants in germinal centres

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

Site‐specific recombination in the immune system 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

DNA sequencing with chain-terminating inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

30 September 2017

The range and fine specificity of the anti-hapten immune response: phylogenetic studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

28 June 2018

Lack of heterogeneity in anti-hapten antibodies of a phylogenetically primitive shark

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

28 June 2018

A hyperconversion mechanism generates the chicken light chain preimmune repertoire.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

28 June 2018

Major reorganization of immunoglobulin VH segmental elements during vertebrate evolution.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

28 June 2018

Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

28 June 2018

The chicken D locus and its contribution to the immunoglobulin heavy chain repertoire.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

28 June 2018

Human immunoglobulin D segments encoded in tandem multigenic families.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2191167

22 September 2018

At least five DH genes of human immunoglobulin heavy chains are encoded in 9-kilobase DNA fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/8350055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel strand exchanges in V(D)J recombination

1 reference

https://pubmed.ncbi.nlm.nih.gov/8350055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organization and evolution of variable region genes of the human immunoglobulin heavy chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/8350055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Somatic hyperconversion diversifies the single Vh gene of the chicken with a high incidence in the D region

1 reference

https://pubmed.ncbi.nlm.nih.gov/8350055

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.178.3.815

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

ResearchGate publication ID

0 references

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