(Q36362370)

13 August 2017

1 reference

title

The silent treatment: siRNAs as small molecule drugs (English)

1 reference

13 August 2017

Dykxhoorn DM

1

1 reference

PubMed ID

16397510

13 August 2017

Palliser D

series ordinal

2

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PubMed ID

16397510

13 August 2017

Lieberman J

series ordinal

3

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13 August 2017

1 March 2006

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13 August 2017

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13 August 2017

13

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13 August 2017

541-552

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13 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/sj.gt.3302703

13 August 2017

0 references

cites work

The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs.

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

The rde-1 gene, RNA interference, and transposon silencing in C. elegans

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

The small RNA profile during Drosophila melanogaster development

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Killing the messenger: short RNAs that silence gene expression

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

The silent revolution: RNA interference as basic biology, research tool, and therapeutic

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Specificity of microRNA target selection in translational repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Targeted mRNA degradation by double-stranded RNA in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Comparison of antisense oligonucleotides and siRNAs in cell culture and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

A microRNA in a multiple-turnover RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Allele-specific silencing of dominant disease genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Activation of the interferon system by short-interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

siRNAs: applications in functional genomics and potential as therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Exogenous siRNA mediates sequence-independent gene suppression by signaling through toll-like receptor 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

siRNAs can function as miRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

The functions of animal microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Rational siRNA design for RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Inhibition of respiratory viruses by nasally administered siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Adenovirus VA1 noncoding RNA can inhibit small interfering RNA and MicroRNA biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Local RNA target structure influences siRNA efficacy: a systematic global analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

In vivo activity of nuclease-resistant siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

siRNA function in RNAi: a chemical modification analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

siRNA relieves chronic neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

RNA interference in mammalian cells by chemically-modified RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

RNAi in human cells: basic structural and functional features of small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Tolerance for mutations and chemical modifications in a siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

RNA interference in adult mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Inhibition of hepatitis B virus in mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Small interfering RNA inhibits hepatitis B virus replication in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Genome-wide RNAi analysis of growth and viability in Drosophila cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Lentivirus-delivered stable gene silencing by RNAi in primary cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Inhibition of influenza virus production in virus-infected mice by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Therapeutic potential of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

siRNA therapeutics: big potential from small RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Short interfering RNAs as a tool for cancer gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Inducible, reversible, and stable RNA interference in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

A genetic screen for candidate tumor suppressors identifies REST

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

A resource for large-scale RNA-interference-based screens in mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Protection against lethal influenza virus challenge by RNA interference in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Antitumor activity of small interfering RNA/cationic liposome complex in mouse models of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Sequence-specific gene silencing in murine muscle induced by electroporation-mediated transfer of short interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Inhibition of gene expression in mice muscle by in vivo electrically mediated siRNA delivery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

RNAi-induced gene silencing by local electroporation in targeting brain region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

RNA interference (RNAi) inhibits growth of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Trypanosome mitochondrial 3' terminal uridylyl transferase (TUTase): the key enzyme in U-insertion/deletion RNA editing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

In vivo gene silencing in Plasmodium berghei--a mouse malaria model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Hydrodynamic liver gene transfer mechanism involves transient sinusoidal blood stasis and massive hepatocyte endocytic vesicles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Apoptosis and liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

The role of Fas and related death receptors in autoimmune and other disease states

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Lethal effect of the anti-Fas antibody in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Fulminant hepatitis by Fas-ligand expression in MRL-lpr/lpr mice grafted with Fas-positive livers and wild-type mice with Fas-mutant livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Caspase 8 small interfering RNA prevents acute liver failure in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Strategies to prevent and control hepatitis B and C virus infections: a global perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Global control of hepatitis B virus infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

Different delivery methods-different expression profiles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

Lack of interferon response in animals to naked siRNAs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

Target accessibility dictates the potency of human RISC

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

siRNA-directed inhibition of HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

RNA interference targeting Fas protects mice from fulminant hepatitis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

RNAi in C. elegans: soaking in the genome sequence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

RNA interference in vivo: toward synthetic small inhibitory RNA-based therapeutics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

Efficient delivery of siRNA for inhibition of gene expression in postnatal mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

Essential roles of the Fas ligand in the development of hepatitis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302703

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302703

1 reference

13 August 2017

1 reference

PubMed ID

16397510