(Q36406416)

14 August 2017

SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat (English)

1 reference

14 August 2017

Caenorhabditis elegans

0 references

0 references

0 references

Dae-Eun Jeong

2

0 references

Hyunmin Kim

object named as

Hyunmin Kim

5

0 references

Seung-Jae Lee

object named as

Seung-Jae V Lee

11

0 references

Youngsook Lee

object named as

Youngsook Lee

10

0 references

author name string

Dongyeop Lee

1

1 reference

14 August 2017

Heehwa G Son

3

1 reference

14 August 2017

Yasuyo Yamaoka

4

1 reference

14 August 2017

Keunhee Seo

6

1 reference

14 August 2017

Abdul Aziz Khan

7

1 reference

14 August 2017

Tae-Young Roh

8

1 reference

14 August 2017

Dae Won Moon

9

1 reference

14 August 2017

language of work or name

1 reference

1 December 2015

1 reference

14 August 2017

1 reference

14 August 2017

29

1 reference

14 August 2017

23

1 reference

14 August 2017

2490-2503

1 reference

describes a project that uses

14 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4691952/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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30 September 2017

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30 September 2017

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30 September 2017

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

30 September 2017

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Genes that act downstream of sensory neurons to influence longevity, dauer formation, and pathogen responses in Caenorhabditis elegans

30 September 2017

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30 September 2017

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30 September 2017

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Fatty acids as biocompounds: their role in human metabolism, health and disease: a review. part 2: fatty acid physiological roles and applications in human health and disease.

30 September 2017

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A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans

30 September 2017

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30 September 2017

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Energy metabolism and ageing regulation: metabolically driven deamidation of triosephosphate isomerase may contribute to proteostatic dysfunction

30 September 2017

1 reference

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AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

A whole-organism screen identifies new regulators of fat storage

30 September 2017

1 reference

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Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity

30 September 2017

1 reference

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Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

30 September 2017

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Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network

30 September 2017

1 reference

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Genetic control of de novo lipogenesis: role in diet-induced obesity

30 September 2017

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30 September 2017

1 reference

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C. elegans major fats are stored in vesicles distinct from lysosome-related organelles

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Glucolipotoxicity of the pancreatic beta cell.

30 September 2017

1 reference

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

30 September 2017

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30 September 2017

The C. elegans intestine

1 reference

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Fatty acid desaturation and the regulation of adiposity in Caenorhabditis elegans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

The nuclear receptor LXR is a glucose sensor

30 September 2017

1 reference

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Acetyl-coenzyme A carboxylases: versatile targets for drug discovery

30 September 2017

1 reference

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Genome-wide RNAi screening identifies protein damage as a regulator of osmoprotective gene expression

30 September 2017

1 reference

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An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

ER stress and SREBP-1 activation are implicated in beta-cell glucolipotoxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Java Treeview--extensible visualization of microarray data

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

C elegans: a model for exploring the genetics of fat storage

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Cluster analysis and display of genome-wide expression patterns

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

The conserved Mediator subunit MDT-15 is required for oxidative stress responses in Caenorhabditis elegans

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Fat accumulation in Caenorhabditis elegans is mediated by SREBP homolog SBP-1

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

C. elegans as model for the study of high glucose- mediated life span reduction

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Transgenic mice overexpressing SREBP-1a under the control of the PEPCK promoter exhibit insulin resistance, but not diabetes

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

The transcription factor SREBP-1c is instrumental in the development of beta-cell dysfunction

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4691952

GeneProf: analysis of high-throughput sequencing experiments

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26637528

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.266304.115

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

26637528

1 reference