(Q36562488)

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Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

scientific article published on January 2013

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

author name string

Ethan Hoffmann

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Jeff Wald

2

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Siva Lavu

3

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

John Roberts

4

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Claire Beaumont

5

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Jon Haddad

6

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Peter Elliott

7

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Christoph Westphal

8

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

Eric Jacobson

9

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

language of work or name

0 references

publication date

1 January 2013

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

British Journal of Clinical Pharmacology

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Europe PubMed Central

PMC publication ID

14 August 2017

75

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

1

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

186-196

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

SRT1720 improves survival and healthspan of obese mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

21 September 2018

Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Resveratrol and health--a comprehensive review of human clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Regulation of FoxO transcription factors by acetylation and protein-protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Lysine acetylation targets protein complexes and co-regulates major cellular functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

SirT1 is an inhibitor of proliferation and tumor formation in colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity by suppressing the nuclear factor-kappaB signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

SirT1 gain of function increases energy efficiency and prevents diabetes in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Sirtuins--novel therapeutic targets to treat age-associated diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Sirt1 protects against high-fat diet-induced metabolic damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

SIRT1 transgenic mice show phenotypes resembling calorie restriction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

SIRT1 activation confers neuroprotection in experimental optic neuritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Sirtuins in mammals: insights into their biological function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

High absorption but very low bioavailability of oral resveratrol in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Current perspectives of 14 C-isotope measurement in biomedical accelerator mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

30 September 2017

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

28 June 2018

Resveratrol upregulated SIRT1, FOXO1, and adiponectin and downregulated PPARγ1-3 mRNA expression in human visceral adipocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

21 September 2018

Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

21 September 2018

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

21 September 2018

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma.

1 reference

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21 September 2018

Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3555058

21 September 2018

Tissue factor pathway inhibitor does not influence inflammatory pathways during human endotoxemia

1 reference

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21 September 2018

Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia

1 reference

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21 September 2018

Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics

1 reference

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21 October 2018

Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening

1 reference

https://pubmed.ncbi.nlm.nih.gov/22616762

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endotoxin down-regulates monocyte and granulocyte interleukin-6 receptors without influencing gp130 expression in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/22616762

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of a metalloproteinase inhibitor (GI5402) on tumor necrosis factor-alpha (TNF-alpha) and TNF-alpha receptors during human endotoxemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/22616762

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.2012.04340.X

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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