(Q36582849)

English

Deficiency in metabolic regulators PPARγ and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration.

scientific article published on 6 December 2012

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scholarly article

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19 February 2020

Deficiency in metabolic regulators PPARγ and PTEN cooperates to drive keratinizing squamous metaplasia in novel models of human tissue regeneration (English)

1 reference

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19 February 2020

Douglas W. Strand

1

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19 February 2020

3

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19 February 2020

Justin M. Cates

10

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19 February 2020

author name string

David J DeGraff

2

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19 February 2020

Mansoureh Sameni

4

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19 February 2020

Omar E Franco

5

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19 February 2020

Harold D Love

6

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19 February 2020

William J Hayward

7

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19 February 2020

Opal Lin-Tsai

8

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19 February 2020

Anne Y Wang

9

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19 February 2020

Bonnie F Sloane

11

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19 February 2020

Robert J Matusik

12

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19 February 2020

Simon W Hayward

13

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19 February 2020

language of work or name

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publication date

6 December 2012

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19 February 2020

The American Journal of Pathology

1 reference

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19 February 2020

182

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19 February 2020

449-459

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19 February 2020

2

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19 February 2020

JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Loss of the urothelial differentiation marker FOXA1 is associated with high grade, late stage bladder cancer and increased tumor proliferation.

1 reference

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MAME models for 4D live-cell imaging of tumor: microenvironment interactions that impact malignant progression

1 reference

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9 September 2017

When urothelial differentiation pathways go wrong: implications for bladder cancer development and progression

1 reference

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The mutational landscape of head and neck squamous cell carcinoma

1 reference

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9 September 2017

Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Functional remodeling of benign human prostatic tissues in vivo by spontaneously immortalized progenitor and intermediate cells

1 reference

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9 September 2017

Autophagy in nuclear receptor PPARgamma-deficient mouse prostatic carcinogenesis

1 reference

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9 September 2017

Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Keratinizing squamous metaplasia of the bladder: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

FOXA1 and IRF-1 intermediary transcriptional regulators of PPARgamma-induced urothelial cytodifferentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

PPARgamma-regulated tight junction development during human urothelial cytodifferentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial

1 reference

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9 September 2017

p63 regulates commitment to the prostate cell lineage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Local recurrence after radical cystectomy for invasive bladder cancer: an analysis of predictive factors

1 reference

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9 September 2017

Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Squamous cell carcinoma of the bladder: pathology, diagnosis and treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Mouse urogenital development: a practical approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Pathological and molecular aspects of prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

The organization, promoter analysis, and expression of the human PPARgamma gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Epithelial-mesenchymal interactions in prostatic development. II. Biochemical observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

Epithelial-mesenchymal interactions in prostatic development. I. morphological observations of prostatic induction by urogenital sinus mesenchyme in epithelium of the adult rodent urinary bladder

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

9 September 2017

PPARγ isoforms differentially regulate metabolic networks to mediate mouse prostatic epithelial differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

30 September 2017

Cutting Edge: Lentiviral short hairpin RNA silencing of PTEN in human mast cells reveals constitutive signals that promote cytokine secretion and cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

30 September 2017

Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3562729

30 September 2017

The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines.

1 reference

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30 September 2017

The endocrinology and developmental biology of the prostate

1 reference

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30 September 2017

PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality

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28 June 2018

Mesenchymal reprogramming of adult human epithelial differentiation

1 reference

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28 June 2018

Glandular epithelial induction by embryonic mesenchyme in adult bladder epithelium of BALB/c mice

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28 June 2018

Spectrum of phosphatidylinositol 3-kinase pathway gene alterations in bladder cancer.

1 reference

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20 September 2018

Effects of PPAR agonists on proliferation and differentiation in human urothelium

1 reference

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20 September 2018

Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis

1 reference

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20 September 2018

Expression of PTEN in the progression of cervical neoplasia and its relation to tumor behavior and angiogenesis in invasive squamous cell carcinoma

1 reference

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20 September 2018

Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases

1 reference

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20 September 2018

Plasticity of the urothelial phenotype: effects of gastro-intestinal mesenchyme/stroma and implications for urinary tract reconstruction

1 reference

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20 September 2018

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild-type and androgen-insensitive (Tfm) mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23219716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of genetic polymorphisms in MDM2, PTEN and P53 with risk of esophageal squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23219716

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.AJPATH.2012.10.007

1 reference

Europe PubMed Central

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19 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23219716%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23219716%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

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