(Q36593671)

English

Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration

scientific article published on 9 November 2012

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration (English)

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

cerebrospinal fluid

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1 reference

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Ronald J Ellis

5

0 references

14

object named as

Igor Grant

1 reference

Europe PubMed Central

15 August 2017

PMC publication ID

15

object named as

Scott Letendre

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Europe PubMed Central

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Susan Morgello

1 reference

Europe PubMed Central

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CHARTER Group

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Europe PubMed Central

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John Allen McCutchan

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J Allen McCutchan

1 reference

Europe PubMed Central

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15 August 2017

Christina M Marra

9

object named as

Christina M Marra

1 reference

Europe PubMed Central

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15 August 2017

Benjamin B Gelman

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Benjamin B Gelman

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Europe PubMed Central

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15 August 2017

Justin C McArthur

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Justin McArthur

1 reference

Europe PubMed Central

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15 August 2017

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Brookie M Best

1 reference

Europe PubMed Central

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15 August 2017

David J Croteau

1

object named as

David Croteau

1 reference

Europe PubMed Central

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15 August 2017

Edmund Capparelli

4

object named as

Edmund Capparelli

1 reference

Europe PubMed Central

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15 August 2017

7

object named as

Ann C Collier

1 reference

Europe PubMed Central

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15 August 2017

author name string

Steven S Rossi

2

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15 August 2017

David B Clifford

6

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Europe PubMed Central

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15 August 2017

David M Simpson

13

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15 August 2017

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publication date

9 November 2012

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Europe PubMed Central

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15 August 2017

Journal of Antimicrobial Chemotherapy

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Europe PubMed Central

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15 August 2017

68

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Europe PubMed Central

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15 August 2017

3

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15 August 2017

684-689

1 reference

Europe PubMed Central

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15 August 2017

Therapeutic amprenavir concentrations in cerebrospinal fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Pharmacokinetics of once-daily darunavir-ritonavir and atazanavir-ritonavir over 72 hours following drug cessation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

1 reference

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9 September 2017

The complexities of antiretroviral drug-drug interactions: role of ABC and SLC transporters

1 reference

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9 September 2017

Structure and function of the blood-brain barrier

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Dynamics of cognitive change in impaired HIV-positive patients initiating antiretroviral therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Darunavir concentrations in cerebrospinal fluid and blood in HIV-1-infected individuals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Low atazanavir concentrations in cerebrospinal fluid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Darunavir: pharmacokinetics and drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Clinical pharmacokinetics of darunavir

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Effects of ritonavir on indinavir pharmacokinetics in cerebrospinal fluid and plasma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

9 September 2017

Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients

1 reference

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9 September 2017

Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

28 June 2018

Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

28 June 2018

Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome. HIV Neurobehavioral Research Center Group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

28 June 2018

Determinants of darunavir cerebrospinal fluid concentrations: impact of once-daily dosing and pharmacogenetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

20 September 2018

Changes in cognition during antiretroviral therapy: comparison of 2 different ranking systems to measure antiretroviral drug efficacy on HIV-associated neurocognitive disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

20 September 2018

Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

20 September 2018

Evaluation of HIV RNA and markers of immune activation as predictors of HIV-associated dementia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

20 September 2018

Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders

1 reference

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20 September 2018

Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3566670

20 September 2018

CSF and serum orosomucoid (alpha-1-acid glycoprotein) in patients with multiple sclerosis: a comparison among particular subgroups of MS patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/23143899

12 December 2020

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10.1093/JAC/DKS441

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 August 2017

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