(Q36629861)

15 August 2017

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title

Maintenance and modulation of T cell polarity (English)

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15 August 2017

Matthew F Krummel

1

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PubMed ID

17053799

15 August 2017

Ian Macara

series ordinal

2

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PubMed ID

17053799

15 August 2017

language of work or name

English

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publication date

1 November 2006

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15 August 2017

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15 August 2017

7

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15 August 2017

1143-1149

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15 August 2017

11

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Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin

15 August 2017

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A single class II myosin modulates T cell motility and stopping, but not synapse formation

21 January 2018

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A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes.

21 January 2018

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ICAMs redistributed by chemokines to cellular uropods as a mechanism for recruitment of T lymphocytes

21 January 2018

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Differential clustering of CD4 and CD3zeta during T cell recognition

21 January 2018

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CD2 molecules redistribute to the uropod during T cell scanning: implications for cellular activation and immune surveillance

21 January 2018

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Compartmentalization in T-cell signalling: membrane microdomains and polarity orchestrate signalling and morphology.

21 January 2018

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Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes.

21 January 2018

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T cells use two directionally distinct pathways for cytokine secretion.

21 January 2018

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Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.

21 January 2018

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Identification of Vangl2 and Scrb1 as planar polarity genes in mammals

21 January 2018

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The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin

21 January 2018

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Thyrotropin receptor trafficking relies on the hScrib-betaPIX-GIT1-ARF6 pathway

21 January 2018

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Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity

21 January 2018

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A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl.

21 January 2018

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The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.

21 January 2018

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Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes

21 January 2018

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Rac regulates integrin-mediated spreading and increased adhesion of T lymphocytes

21 January 2018

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The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.

21 January 2018

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WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo

21 January 2018

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Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis

21 January 2018

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The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation

21 January 2018

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WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility

21 January 2018

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A Pak- and Pix-dependent branch of the SDF-1alpha signalling pathway mediates T cell chemotaxis across restrictive barriers

21 January 2018

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Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration

21 January 2018

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The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.

21 January 2018

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Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation.

21 January 2018

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An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration

21 January 2018

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Mammalian Scribble forms a tight complex with the betaPIX exchange factor

21 January 2018

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Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein

21 January 2018

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Two independent domains of hDlg are sufficient for subcellular targeting: the PDZ1-2 conformational unit and an alternatively spliced domain

21 January 2018

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Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

21 January 2018

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

21 January 2018

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Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish

21 January 2018

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The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis

21 January 2018

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Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.

21 January 2018

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Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.

21 January 2018

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Antigen receptor engagement delivers a stop signal to migrating T lymphocytes.

21 January 2018

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Polarity of T cell shape, motility, and sensitivity to antigen

21 January 2018

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Discs large (Dlg1) complexes in lymphocyte activation

21 January 2018

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Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells

21 January 2018

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

21 January 2018

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Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

21 January 2018

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Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

21 January 2018

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Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

21 January 2018

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Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes

21 January 2018

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GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes

21 January 2018

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T cell receptor signaling precedes immunological synapse formation

21 January 2018

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Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1.

21 January 2018

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A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

21 January 2018

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Parsing the polarity code

21 January 2018

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Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation

21 January 2018

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 January 2018

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Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels

21 January 2018

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Recruitment of transferrin receptor to immunological synapse in response to TCR engagement.

21 January 2018

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The distal pole complex: a novel membrane domain distal to the immunological synapse

21 January 2018

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

21 January 2018

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Wasp recruitment to the T cell:APC contact site occurs independently of Cdc42 activation

21 January 2018

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Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

21 January 2018

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The immunological synapse balances T cell receptor signaling and degradation

21 January 2018

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Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells

21 January 2018

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Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

21 January 2018

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Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization.

21 January 2018

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

21 January 2018

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Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation

21 January 2018

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Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment

21 January 2018

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Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

21 January 2018

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A role for the immunological synapse in lineage commitment of CD4 lymphocytes.

21 January 2018

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

21 January 2018

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The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction

21 January 2018

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Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells

21 January 2018

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Rab17 regulates membrane trafficking through apical recycling endosomes in polarized epithelial cells

21 January 2018

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JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin

21 January 2018

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T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases

21 January 2018

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A receptor/cytoskeletal movement triggered by costimulation during T cell activation

21 January 2018

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7 January 2021

Regulation of synaptic plasticity and synaptic vesicle dynamics by the PDZ protein Scribble.

1 reference

7 January 2021

A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation

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7 January 2021

Role of Rho in chemoattractant-activated leukocyte adhesion through integrins

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7 January 2021

Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow

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7 January 2021

A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

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7 January 2021

ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation

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7 January 2021

Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylation

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7 January 2021

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

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7 January 2021

Surface-bound chemokines capture and prime T cells for synapse formation

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7 January 2021

Identifiers

DOI

10.1038/NI1404

1 reference

15 August 2017

1 reference

PubMed ID

17053799