(Q36630012)

15 August 2017

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title

Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders (English)

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15 August 2017

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1

Julian L Griffin

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15 August 2017

Andrew W Nicholls

2

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15 August 2017

1 October 2006

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15 August 2017

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15 August 2017

7

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15 August 2017

1095-1107

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15 August 2017

7

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Systematic functional analysis of the yeast genome

15 August 2017

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

From genomes to systems: the path with yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Potential of metabolomics as a functional genomics tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Gut microorganisms, mammalian metabolism and personalized health care

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

High-throughput classification of yeast mutants for functional genomics using metabolic footprinting.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabolite profiling for plant functional genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

A Functional Analysis of Mouse Models of Cardiac Disease through Metabolic Profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

The epidemiology of Type 2 diabetes and its current measurement

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabolomics applications of FT-ICR mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabolic profiles of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabolic profiles of dystrophin and utrophin expression in mouse models of Duchenne muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Studying rat brain neurochemistry using nanoprobe NMR spectroscopy: a metabonomics approach

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabolomic analysis of the consequences of cadmium exposure in Silene cucubalus cell cultures via 1H NMR spectroscopy and chemometrics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Matrix-suppressed laser desorption/ionisation mass spectrometry and its suitability for metabolome analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Lipid profiling by multiple precursor and neutral loss scanning driven by the data-dependent acquisition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Extraction and GC/MS analysis of the human blood plasma metabolome

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Effects of feeding and body weight loss on the 1H-NMR-based urine metabolic profiles of male Wistar Han rats: implications for biomarker discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Pattern recognition techniques in microarray data analysis: a survey

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterising and interpreting complex biological NMR spectra

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Analysis of fetal and neonatal urine using proton nuclear magnetic resonance spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabonomic investigations into hydrazine toxicity in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabolic phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Sexual dimorphism in urinary metabolite profiles of Han Wistar rats revealed by nuclear-magnetic-resonance-based metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabonomic identification of two distinct phenotypes in Sprague-Dawley (Crl:CD(SD)) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

A 1H NMR-based metabonomic study of urine and plasma samples obtained from healthy human subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Pharmaco-metabonomic phenotyping and personalized drug treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabolic profiling of livers and blood from obese Zucker rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

A combined (1)H NMR and HPLC-MS-based metabonomic study of urine from obese (fa/fa) Zucker and normal Wistar-derived rats

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Shotgun lipidomics identifies cardiolipin depletion in diabetic myocardium linking altered substrate utilization with mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N-methylnicotinamide and N-methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Peroxisomal proliferator-activated receptor alpha deficiency diminishes insulin-responsiveness of gluconeogenic/glycolytic/pentose gene expression and substrate cycle flux.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Lipid metabolome-wide effects of the PPARgamma agonist rosiglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Sequential ordered fatty acid alpha oxidation and Delta9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Nutrigenomics: the impact of biomics technology on nutrition research

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabolomics: an emerging post-genomic tool for nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mellitus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Integrative biological analysis of the APOE*3-leiden transgenic mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Proton NMR analysis of plasma is a weak predictor of coronary artery disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabolomic identification of novel biomarkers of myocardial ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabolic profiling of rodent biological fluids via 1H NMR spectroscopy using a 1 mm microlitre probe

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Cryogenic Probe13C NMR Spectroscopy of Urine for Metabonomic Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Multi-Component Metabolic Classification of Commercial Feverfew Preparations via High-Field 1H-NMR Spectroscopy and Chemometrics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Chemometric Models for Toxicity Classification Based on NMR Spectra of Biofluids

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Statistical methods for comparing comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry results: Metabolomic analysis of mouse tissue extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2F14622416.7.7.1095

10.2217/14622416.7.7.1095

21 January 2018

Identifiers

DOI

1 reference

15 August 2017

1 reference

PubMed ID

17054419