(Q36639261)

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Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42)) administered intramuscularly with adjuvant system AS01.

scientific article published on 23 January 2013

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Europe PubMed Central

PMC publication ID

15 August 2017

Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42)) administered intramuscularly with adjuvant system AS01. (English)

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15 August 2017

Plasmodium falciparum

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Elke S Bergmann-Leitner

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Elke Bergmann-Leitner

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Bernhards Ogutu

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Bernhards Ogutu

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Marie-Claude Dubois

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Marie-Claude Dubois

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Christian F Ockenhouse

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Christian F Ockenhouse

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Nekoye Otsyula

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Margaret Koech

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Farhat Khan

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Jason Bennett

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James Cummings

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Meng Shi

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Lori Miller

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Walter Otieno

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Godfrey Allan Otieno

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Brent House

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Olivier Godeaux

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Joe Cohen

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Mark Polhemus

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publication date

23 January 2013

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Malaria Journal

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15 August 2017

copyright license

Creative Commons Attribution 2.0 Generic

23 January 2013

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April 2022 Public Data File from Crossref

copyright status

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April 2022 Public Data File from Crossref

Phase 1 trial of the Plasmodium falciparum blood stage vaccine MSP1(42)-C1/Alhydrogel with and without CPG 7909 in malaria naïve adults

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The clinical-grade 42-kilodalton fragment of merozoite surface protein 1 of Plasmodium falciparum strain FVO expressed in Escherichia coli protects Aotus nancymai against challenge with homologous erythrocytic-stage parasites

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Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia

1 reference

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Biochemical and immunological characterization of bacterially expressed and refolded Plasmodium falciparum 42-kilodalton C-terminal merozoite surface protein 1.

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A new rodent model to assess blood stage immunity to the Plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies

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The human immune response to Plasmodium falciparum includes both antibodies that inhibit merozoite surface protein 1 secondary processing and blocking antibodies

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Identifiers

10.1186/1475-2875-12-29

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Europe PubMed Central

PMC publication ID

15 August 2017

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Europe PubMed Central

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15 August 2017

PubMed publication ID

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15 August 2017

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