(Q36704486)

15 August 2017

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title

The role of SLAM family receptors in immune cell signaling (English)

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15 August 2017

Elena A Ostrakhovitch

series ordinal

1

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PubMed ID

17215871

15 August 2017

Shawn S-C Li

series ordinal

2

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15 August 2017

1 December 2006

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Biochemistry and Cell Biology

15 August 2017

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15 August 2017

84

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15 August 2017

832-843

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15 August 2017

6

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NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition

15 August 2017

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Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase

21 January 2018

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NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions.

21 January 2018

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SLAM and its role in T cell activation and Th cell responses

21 January 2018

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Fine-tuning of immune responses by SLAM-related receptors

21 January 2018

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Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines

21 January 2018

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Molecular cloning of CS1, a novel human natural killer cell receptor belonging to the CD2 subset of the immunoglobulin superfamily

21 January 2018

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Molecular characterization of a novel human natural killer cell receptor homologous to mouse 2B4

21 January 2018

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2B4 (CD244) and CS1: novel members of the CD2 subset of the immunoglobulin superfamily molecules expressed on natural killer cells and other leukocytes

21 January 2018

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Signaling for NKT cell development: the SAP-FynT connection

21 January 2018

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NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease

21 January 2018

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Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family

21 January 2018

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SAP couples Fyn to SLAM immune receptors

21 January 2018

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Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors

21 January 2018

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2B4 stimulation of YT cells induces natural killer cell cytolytic function and invasiveness

21 January 2018

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Protein kinase C is involved in 2B4 (CD244)-mediated cytotoxicity and AP-1 activation in natural killer cells

21 January 2018

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Integration of T cell receptor-dependent signaling pathways by adapter proteins

21 January 2018

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A novel receptor involved in T-cell activation

21 January 2018

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Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene

21 January 2018

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Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease.

21 January 2018

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Altered lymphocyte responses and cytokine production in mice deficient in the X-linked lymphoproliferative disease gene SH2D1A/DSHP/SAP

21 January 2018

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Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9.

21 January 2018

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The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)

21 January 2018

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SAP controls the cytolytic activity of CD8+ T cells against EBV-infected cells.

21 January 2018

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Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244).

21 January 2018

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Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells.

21 January 2018

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Identification and characterization of SF2000 and SF2001, two new members of the immune receptor SLAM/CD2 family

21 January 2018

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Diagnosis of X-linked lymphoproliferative disease by analysis of SLAM-associated protein expression.

21 January 2018

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Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice.

21 January 2018

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Measles virus interacts with human SLAM receptor on dendritic cells to cause immunosuppression

21 January 2018

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Signaling lymphocytic activation molecule (SLAM) regulates T cellular cytotoxicity.

21 January 2018

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Dexamethasone up-regulates the inhibitory adaptor protein Dok-1 and suppresses downstream activation of the mitogen-activated protein kinase pathway in antigen-stimulated RBL-2H3 mast cells

21 January 2018

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The role of SAP in murine CD150 (SLAM)-mediated T-cell proliferation and interferon gamma production.

21 January 2018

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Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation

21 January 2018

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Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions.

21 January 2018

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SH2D1A regulates T-dependent humoral autoimmunity

21 January 2018

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A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

21 January 2018

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Cutting edge: Regulation of CD8(+) T cell proliferation by 2B4/CD48 interactions

21 January 2018

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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

21 January 2018

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Cloning, expression, and function of BLAME, a novel member of the CD2 family.

21 January 2018

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Structure-function effects in primary immunodeficiencies.

21 January 2018

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Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84

21 January 2018

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Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta

21 January 2018

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Regulation of B cell tolerance by the lupus susceptibility gene Ly108.

21 January 2018

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CS1, a novel member of the CD2 family, is homophilic and regulates NK cell function

21 January 2018

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Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

21 January 2018

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Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

21 January 2018

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Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs

21 January 2018

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Thy-1/CD3 coengagement promotes TCR signaling and enhances particularly tyrosine phosphorylation of the raft molecule LAT.

21 January 2018

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Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction

21 January 2018

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Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A

21 January 2018

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Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors

21 January 2018

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The human and mouse complement of SH2 domain proteins-establishing the boundaries of phosphotyrosine signaling

21 January 2018

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The SH2 domain: versatile signaling module and pharmaceutical target

21 January 2018

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Insights into seven and single transmembrane-spanning domain receptors and their signaling pathways in human natural killer cells.

21 January 2018

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CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1

21 January 2018

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Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229.

21 January 2018

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Mutational analysis of the human 2B4 (CD244)/CD48 interaction: Lys68 and Glu70 in the V domain of 2B4 are critical for CD48 binding and functional activation of NK cells

21 January 2018

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CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells

21 January 2018

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The adaptor protein SH2D1A regulates signaling through CD150 (SLAM) in B cells

21 January 2018

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Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis.

21 January 2018

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X-linked lymphoproliferative disease: a progressive immunodeficiency

21 January 2018

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Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells

21 January 2018

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SH2D1A expression in Burkitt lymphoma cells is restricted to EBV positive group I lines and is downregulated in parallel with immunoblastic transformation.

21 January 2018

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The X-linked lymphoproliferative disease gene product SAP is expressed in activated T and NK cells.

21 January 2018

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Wild-type p53 activates SAP expression in lymphoid cells.

21 January 2018

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Activating interactions in human NK cell recognition: the role of 2B4-CD48

21 January 2018

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Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity

21 January 2018

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Novel targets for antithrombotic drug discovery

21 January 2018

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Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling

21 January 2018

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Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

21 January 2018

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Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains

21 January 2018

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X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells

21 January 2018

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Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

21 January 2018

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Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition

21 January 2018

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Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes

21 January 2018

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Dynamic redistribution of the activating 2B4/SAP complex at the cytotoxic NK cell immune synapse

21 January 2018

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Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)

21 January 2018

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CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse

21 January 2018

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Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

21 January 2018

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The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

21 January 2018

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Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4.

21 January 2018

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Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP

21 January 2018

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Characterization of inhibitory and stimulatory forms of the murine natural killer cell receptor 2B4.

21 January 2018

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An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2

21 January 2018

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Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure

21 January 2018

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X-linked lymphoproliferative disease: twenty-five years after the discovery

21 January 2018

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Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signalling, but dispensable for rasGAP-binding

21 January 2018

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CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A

21 January 2018

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The dual-function CD150 receptor subfamily: the viral attraction

21 January 2018

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SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9.

21 January 2018

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Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation

21 January 2018

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The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B

21 January 2018

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Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome

21 January 2018

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CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2

21 January 2018

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Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation

21 January 2018

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Of mice and men: different functions of the murine and human 2B4 (CD244) receptor on NK cells

21 January 2018

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NTB-A, a new activating receptor in T cells that regulates autoimmune disease

21 January 2018

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Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes

21 January 2018

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SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors

21 January 2018

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Immune regulation by SLAM family receptors and SAP-related adaptors

21 January 2018

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Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus

21 January 2018

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The cell surface receptor SLAM controls T cell and macrophage functions

21 January 2018

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Natural killer cell inhibitory receptors block actin cytoskeleton-dependent recruitment of 2B4 (CD244) to lipid rafts

21 January 2018

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NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)

21 January 2018

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CD84 expression on human hematopoietic progenitor cells

21 January 2018

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Phosphoinositide 3-kinase-dependent membrane recruitment of p62(dok) is essential for its negative effect on mitogen-activated protein (MAP) kinase activation

21 January 2018

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Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap

21 January 2018

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Cutting Edge: Signaling Lymphocytic Activation Molecule-Associated Protein Controls NKT Cell Functions

21 January 2018

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O06-191

1 reference

15 August 2017

1 reference

PubMed ID

17215871