(Q36715280)

15 August 2017

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title

Key factors in the organized chaos of early T cell development (English)

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15 August 2017

Daniel J Pennington

2

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author name string

Adrian C Hayday

series ordinal

1

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PubMed ID

17242687

15 August 2017

language of work or name

English

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publication date

1 February 2007

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15 August 2017

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15 August 2017

8

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15 August 2017

137-144

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15 August 2017

2

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A variable immunoreceptor in a subpopulation of human neutrophils

15 August 2017

1 reference

7 January 2021

Orchestrated leak provokes a thymus reassessment

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7 January 2021

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1 reference

7 January 2021

Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages

1 reference

7 January 2021

New insights into the proliferation and differentiation of early mouse thymocytes

1 reference

7 January 2021

Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.

1 reference

7 January 2021

Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus

1 reference

7 January 2021

The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage, and natural killer cell but no B-lymphocyte potential.

1 reference

7 January 2021

Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands

1 reference

7 January 2021

T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice

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7 January 2021

Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes

1 reference

7 January 2021

Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: a critical role for the beta chain in development.

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7 January 2021

Alpha beta and gamma delta T cells can share a late common precursor

1 reference

7 January 2021

Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells

1 reference

7 January 2021

Intrathymic delta selection events in gammadelta cell development.

1 reference

7 January 2021

Selection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant

1 reference

7 January 2021

Positive selection of dendritic epidermal gammadelta T cell precursors in the fetal thymus determines expression of skin-homing receptors

1 reference

7 January 2021

[gamma][delta] cells: a right time and a right place for a conserved third way of protection

1 reference

7 January 2021

Migration of naive, effector and memory T cells: implications for the regulation of immune responses

1 reference

7 January 2021

Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway.

1 reference

7 January 2021

The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs

1 reference

7 January 2021

Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus.

1 reference

7 January 2021

Biological insights into TCRgammadelta+ and TCRalphabeta+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE).

1 reference

7 January 2021

1 reference

7 January 2021

Notch signaling: cell fate control and signal integration in development

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7 January 2021

T/B lineage choice occurs prior to intrathymic Notch signaling.

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7 January 2021

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

1 reference

7 January 2021

Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

1 reference

7 January 2021

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

1 reference

7 January 2021

Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

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7 January 2021

The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation.

1 reference

7 January 2021

Three-dimensional architecture of the thymus is required to maintain delta-like expression necessary for inducing T cell development.

1 reference

7 January 2021

Notch signaling controls the generation and differentiation of early T lineage progenitors

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7 January 2021

Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

1 reference

7 January 2021

Visualization of the earliest steps of gammadelta T cell development in the adult thymus.

1 reference

7 January 2021

Restricted STAT5 activation dictates appropriate thymic B versus T cell lineage commitment.

1 reference

7 January 2021

The interleukin 7 receptor is required for T cell receptor gamma locus accessibility to the V(D)J recombinase

1 reference

7 January 2021

Mechanisms Controlling Termination of V-J Recombination at the TCR Locus: Implications for Allelic and Isotypic Exclusion of TCR Chains

1 reference

7 January 2021

Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

1 reference

7 January 2021

Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation

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7 January 2021

Active form of Notch imposes T cell fate in human progenitor cells

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7 January 2021

Sustained Notch1 signaling instructs the earliest human intrathymic precursors to adopt a gammadelta T-cell fate in fetal thymus organ culture.

1 reference

7 January 2021

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

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7 January 2021

Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

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7 January 2021

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

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7 January 2021

Role of different T cell receptors in the development of pre-T cells.

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7 January 2021

Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.

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7 January 2021

The alpha beta T cell receptor can replace the gamma delta receptor in the development of gamma delta lineage cells.

1 reference

7 January 2021

A TCR alpha chain transgene induces maturation of CD4- CD8- alpha beta+ T cells from gamma delta T cell precursors

1 reference

7 January 2021

Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma

1 reference

7 January 2021

TCR signal strength influences alphabeta/gammadelta lineage fate

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7 January 2021

Attenuation of gammadeltaTCR signaling efficiently diverts thymocytes to the alphabeta lineage.

1 reference

7 January 2021

Recent insights into the signals that control alphabeta/gammadelta-lineage fate.

1 reference

7 January 2021

Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development

1 reference

7 January 2021

An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors

1 reference

7 January 2021

Different initiation of pre-TCR and gammadeltaTCR signalling

1 reference

7 January 2021

LAT regulates gammadelta T cell homeostasis and differentiation

1 reference

7 January 2021

Early TCR alpha beta expression promotes maturation of T cells expressing Fc epsilon RI gamma containing TCR/CD3 complexes.

1 reference

7 January 2021

Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

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7 January 2021

p38 MAP kinase activity modulates alpha beta T cell development

1 reference

7 January 2021

Premature expression of T cell receptor (TCR)alphabeta suppresses TCRgammadelta gene rearrangement but permits development of gammadelta lineage T cells

1 reference

7 January 2021

Strength of signal: a fundamental mechanism for cell fate specification

1 reference

7 January 2021

A critical role for the cytoplasmic tail of pTα in T lymphocyte development

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7 January 2021

Cutting edge: a chemical genetic system for the analysis of kinases regulating T cell development

1 reference

7 January 2021

Rates of recombination and chain pair biases greatly influence the primary gammadelta TCR repertoire in the thymus of adult mice

1 reference

7 January 2021

Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling.

1 reference

7 January 2021

Early expression of a functional TCRbeta chain inhibits TCRgamma gene rearrangements without altering the frequency of TCRgammadelta lineage cells.

1 reference

7 January 2021

Delayed and restricted expression limits putative instructional opportunities of Vgamma1.1/Vgamma2 gammadelta TCR in alphabeta/gammadelta lineage choice in the thymus.

1 reference

7 January 2021

Preferential activation of an IL-2 regulatory sequence transgene in TCR gamma delta and NKT cells: subset-specific differences in IL-2 regulation.

1 reference

7 January 2021

Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes

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7 January 2021

Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22.

1 reference

7 January 2021

Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors

1 reference

7 January 2021

Mapping precursor movement through the postnatal thymus reveals specific microenvironments supporting defined stages of early lymphoid development

1 reference

7 January 2021

Feedback regulation of T cell development in the thymus.

1 reference

7 January 2021

Early events in the thymus affect the balance of effector and regulatory T cells

1 reference

7 January 2021

Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity.

1 reference

7 January 2021

Environmentally Responsive and Reversible Regulation of Epidermal Barrier Function by γδ T Cells

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7 January 2021

Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches.

1 reference

7 January 2021

Evidence for a functional second thymus in mice

1 reference

7 January 2021

Identifiers

DOI

10.1038/NI1436

1 reference

15 August 2017

1 reference

PubMed ID

17242687