(Q36720943)

15 August 2017

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title

Regulation of T-cell activation by the cytoskeleton (English)

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15 August 2017

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1

Daniel D Billadeau

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15 August 2017

Jeffrey C Nolz

2

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PubMed ID

17259969

15 August 2017

Timothy S Gomez

series ordinal

3

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15 August 2017

1 February 2007

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Nature Reviews Immunology

15 August 2017

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15 August 2017

7

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15 August 2017

131-143

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15 August 2017

2

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Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments.

15 August 2017

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Cutting edge: integration of human T lymphocyte cytoskeleton by the cytolinker plectin

21 January 2018

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Regulation of sustained actin dynamics by the TCR and costimulation as a mechanism of receptor localization

21 January 2018

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Superantigen-induced T cell:B cell conjugation is mediated by LFA-1 and requires signaling through Lck, but not ZAP-70.

21 January 2018

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Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

21 January 2018

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SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site

21 January 2018

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Specific patterns of Cdc42 activity are related to distinct elements of T cell polarization

21 January 2018

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Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production

21 January 2018

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Linker for activation of T cells, zeta-associated protein-70, and Src homology 2 domain-containing leukocyte protein-76 are required for TCR-induced microtubule-organizing center polarization

21 January 2018

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Role of Fyn in the rearrangement of tubulin cytoskeleton induced through TCR.

21 January 2018

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Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein

21 January 2018

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Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion

21 January 2018

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Role of the cytoskeleton during leukocyte responses

21 January 2018

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Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions

31 March 2020

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Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

31 March 2020

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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

31 March 2020

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The specific direct interaction of helper T cells and antigen-presenting B cells. II. Reorientation of the microtubule organizing center and reorganization of the membrane-associated cytoskeleton inside the bound helper T cells

31 March 2020

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The distal pole complex: a novel membrane domain distal to the immunological synapse

31 March 2020

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Differential clustering of CD4 and CD3zeta during T cell recognition

31 March 2020

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Immune synapses in T-cell activation

31 March 2020

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Immunological synapse and microclusters: the site for recognition and activation of T cells

31 March 2020

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Three-dimensional segregation of supramolecular activation clusters in T cells

31 March 2020

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Direct observation of ligand recognition by T cells.

31 March 2020

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Lipid rafts in lymphocyte activation and migration

31 March 2020

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Lipid rafts: now you see them, now you don't

31 March 2020

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A dynamic view of the immunological synapse

31 March 2020

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The immunological synapse of CTL contains a secretory domain and membrane bridges.

31 March 2020

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Centrosome polarization delivers secretory granules to the immunological synapse.

31 March 2020

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

31 March 2020

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Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels

31 March 2020

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

31 March 2020

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Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation

31 March 2020

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Searching for significance in TCR-cytoskeleton interactions

31 March 2020

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Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon Activation of mature T lymphocytes

31 March 2020

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The Wiskott-Aldrich syndrome protein: forging the link between actin and cell activation

31 March 2020

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

31 March 2020

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VAV proteins as signal integrators for multi-subunit immune-recognition receptors

31 March 2020

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The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface

31 March 2020

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Intracellular signalling controlling integrin activation in lymphocytes

31 March 2020

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Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.

31 March 2020

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Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

31 March 2020

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WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation

31 March 2020

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The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse

31 March 2020

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Vav-family proteins in T-cell signalling

31 March 2020

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HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse

31 March 2020

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Regulation of cytoskeletal dynamics at the immune synapse: new stars join the actin troupe

31 March 2020

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Staying in shape with formins

31 March 2020

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Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse

31 March 2020

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Translocation of PKC[theta] in T cells is mediated by a nonconventional, PI3-K- and Vav-dependent pathway, but does not absolutely require phospholipase C

31 March 2020

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Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells

31 March 2020

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ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugation

31 March 2020

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Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signaling

31 March 2020

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The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation

31 March 2020

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Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells

31 March 2020

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The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation

31 March 2020

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Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes

31 March 2020

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Role for the Abi/wave protein complex in T cell receptor-mediated proliferation and cytoskeletal remodeling.

31 March 2020

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Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse

31 March 2020

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Polycomb group protein ezh2 controls actin polymerization and cell signaling.

31 March 2020

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HIP-55 is important for T-cell proliferation, cytokine production, and immune responses

31 March 2020

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Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis

31 March 2020

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Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells

31 March 2020

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A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation

31 March 2020

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Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

31 March 2020

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Requirement for coronin 1 in T lymphocyte trafficking and cellular homeostasis

31 March 2020

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Cofilin peptide homologs interfere with immunological synapse formation and T cell activation

31 March 2020

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Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration

31 March 2020

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Gelsolin superfamily proteins: key regulators of cellular functions.

31 March 2020

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Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells

31 March 2020

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Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

31 March 2020

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Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based activation motif-dependent mechanism

31 March 2020

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Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42

31 March 2020

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Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells

31 March 2020

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Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells

31 March 2020

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Lytic versus stimulatory synapse in cytotoxic T lymphocyte/target cell interaction: manifestation of a dual activation threshold

31 March 2020

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Recruitment of dynein to the Jurkat immunological synapse

31 March 2020

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HDAC6 deacetylase activity links the tubulin cytoskeleton with immune synapse organization

31 March 2020

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The immunological synapse: a molecular machine controlling T cell activation

31 March 2020

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Tyrosine kinase activity and remodelling of the actin cytoskeleton are co-temporally required for degranulation by cytotoxic T lymphocytes.

31 March 2020

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The immunological synapse balances T cell receptor signaling and degradation

31 March 2020

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Defective Vav expression and impaired F-actin reorganization in a subset of patients with common variable immunodeficiency characterized by T-cell defects

31 March 2020

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The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways

31 March 2020

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Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation

31 March 2020

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Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.

31 March 2020

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T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

31 March 2020

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VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses

31 March 2020

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Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1

31 March 2020

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A novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptor

31 March 2020

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Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

31 March 2020

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TEC-family kinases: regulators of T-helper-cell differentiation

31 March 2020

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Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1

31 March 2020

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Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling

31 March 2020

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Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion

31 March 2020

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Negative regulation of T cell antigen receptor-mediated Crk-L-C3G signaling and cell adhesion by Cbl-b.

31 March 2020

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T cell development and function in CrkL‐deficient mice

31 March 2020

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RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1

31 March 2020

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Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion

31 March 2020

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Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.

31 March 2020

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RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

31 March 2020

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Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3.

31 March 2020

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SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

31 March 2020

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Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

31 March 2020

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Coupling of the TCR to integrin activation by Slap-130/Fyb.

31 March 2020

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The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1

31 March 2020

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Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130

31 March 2020

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FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells

31 March 2020

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Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells

31 March 2020

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Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton

31 March 2020

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Talin1 regulates TCR-mediated LFA-1 function

31 March 2020

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The actin cloud induced by LFA-1-mediated outside-in signals lowers the threshold for T-cell activation

31 March 2020

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Focal adhesions - the cytoskeletal connection

31 March 2020

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Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion

31 March 2020

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Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates

31 March 2020

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Multiple connections link FAK to cell motility and invasion

31 March 2020

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Focal adhesion kinase: the first ten years

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2021

1 reference

15 August 2017

1 reference

PubMed ID

17259969