(Q36772357)

16 August 2017

Modifications to the tetracaine scaffold produce cyclic nucleotide-gated channel blockers with widely varying efficacies (English)

1 reference

16 August 2017

1 reference

Timothy Strassmaier

1

1 reference

16 August 2017

Ramalinga Uma

2

1 reference

16 August 2017

Ambarish S Ghatpande

3

1 reference

16 August 2017

Tapasree Bandyopadhyay

4

1 reference

16 August 2017

Michelle Schaffer

5

1 reference

16 August 2017

John Witte

6

1 reference

16 August 2017

Patrick G McDougal

7

1 reference

16 August 2017

R Lane Brown

8

1 reference

16 August 2017

Jeffrey W Karpen

9

1 reference

16 August 2017

language of work or name

English

0 references

publication date

1 September 2005

1 reference

Journal of Medicinal Chemistry

16 August 2017

1 reference

16 August 2017

48

1 reference

16 August 2017

18

1 reference

16 August 2017

5805-5812

1 reference

X-ray structure of a voltage-dependent K+ channel

16 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Rod cyclic nucleotide-gated channels have a stoichiometry of three CNGA1 subunits and one CNGB1 subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Subunit stoichiometry of the CNG channel of rod photoreceptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Cyclic nucleotide-gated ion channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Molecular mechanisms of gating and drug block of sodium channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Blockade of a retinal cGMP-gated channel by polyamines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Sodium channel selectivity filter regulates antiarrhythmic drug binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Tetracaine reports a conformational change in the pore of cyclic nucleotide-gated channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Mechanism of tetracaine block of cyclic nucleotide-gated channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Subunit interactions in the activation of cyclic nucleotide-gated ion channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Probing the transmembrane topology of cyclic nucleotide-gated ion channels with a gene fusion approach.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

A single negative charge within the pore region of a cGMP-gated channel controls rectification, Ca2+ blockage, and ionic selectivity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Ionic Blockage of Sodium Channels in Nerve

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Hindered diffusion in excised membrane patches from retinal rod outer segments

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

A cyclic nucleotide-gated conductance in olfactory receptor cilia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Gating kinetics of the cyclic-GMP-activated channel of retinal rods: flash photolysis and voltage-jump studies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Single cyclic GMP-activated channel activity in excised patches of rod outer segment membrane

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Block of the cyclic GMP-gated channel of vertebrate rod and cone photoreceptors by l-cis-diltiazem

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Cyclic nucleotide-gated channels. Pore topology studied through the accessibility of reporter cysteines

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Calcium channel characteristics conferred on the sodium channel by single mutations

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

A Functional Connection Between the Pores of Distantly Related Ion Channels as Revealed by Mutant K + Channels

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

A multiply charged tetracaine derivative blocks cyclic nucleotide-gated channels at subnanomolar concentrations

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Single cyclic nucleotide-gated channels locked in different ligand-bound states.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Cyclic GMP-sensitive conductance of retinal rods consists of aqueous pores

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2467444

Subunit stoichiometry of cyclic nucleotide-gated channels and effects of subunit order on channel function

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16134947

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Spanning binding sites on allosteric proteins with polymer-linked ligand dimers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16134947

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1021/JM0502485

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

16134947

1 reference