(Q36831668)

16 August 2017

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title

SOCS proteins, cytokine signalling and immune regulation (English)

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16 August 2017

Akihiko Yoshimura

1

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PubMed ID

17525754

16 August 2017

Tetsuji Naka

series ordinal

2

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PubMed ID

17525754

16 August 2017

Masato Kubo

series ordinal

3

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16 August 2017

18 May 2007

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Nature Reviews Immunology

16 August 2017

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16 August 2017

7

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16 August 2017

454-465

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16 August 2017

6

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Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

16 August 2017

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Negative regulation of cytokine and TLR signalings by SOCS and others

31 March 2020

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Regulation of the immune system by SOCS family adaptor proteins

31 March 2020

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SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.

31 March 2020

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The role of suppressors of cytokine signalling in thymopoiesis and T cell activation

31 March 2020

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Suppressors of cytokine signaling and immunity

31 March 2020

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VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

31 March 2020

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SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome

31 March 2020

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Characterization of a peptide inhibitor of Janus kinase 2 that mimics suppressor of cytokine signaling 1 function

31 March 2020

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Both the suppressor of cytokine signaling 1 (SOCS-1) kinase inhibitory region and SOCS-1 mimetic bind to JAK2 autophosphorylation site: implications for the development of a SOCS-1 antagonist

31 March 2020

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Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase

31 March 2020

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Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3

31 March 2020

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The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

31 March 2020

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The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6.

31 March 2020

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Pim serine/threonine kinases regulate the stability of Socs-1 protein

31 March 2020

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Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3.

31 March 2020

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Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

31 March 2020

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Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation

31 March 2020

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Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

31 March 2020

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Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent

31 March 2020

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SOCS-1 participates in negative regulation of LPS responses

31 March 2020

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SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

31 March 2020

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Interferon gamma receptor deficient mice are resistant to endotoxic shock

31 March 2020

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Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene

31 March 2020

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Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved.

31 March 2020

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Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling

31 March 2020

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Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.

31 March 2020

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Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

31 March 2020

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SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation

31 March 2020

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Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells

31 March 2020

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IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia

31 March 2020

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Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT

31 March 2020

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Role of toll-like receptors in spontaneous commensal-dependent colitis

31 March 2020

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IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice

31 March 2020

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Colitis in transgenic and knockout animals as models of human inflammatory bowel disease

31 March 2020

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IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

31 March 2020

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General nature of the STAT3-activated anti-inflammatory response.

31 March 2020

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The JAK-STAT signaling pathway: input and output integration

31 March 2020

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Expression of constitutively active STAT3 can replicate the cytokine-suppressive activity of interleukin-10 in human primary macrophages.

31 March 2020

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An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity.

31 March 2020

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IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages.

31 March 2020

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Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue

31 March 2020

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Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway

31 March 2020

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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

31 March 2020

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Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production.

31 March 2020

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Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma

31 March 2020

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Prostaglandin E2 augments IL-10 signaling and function

31 March 2020

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Suppressor of cytokine signalling-3 at pathological levels does not regulate lipopolysaccharide or interleukin-10 control of tumour necrosis factor-alpha production by human monocytes.

31 March 2020

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IL-10 inhibits lipopolysaccharide-induced CD40 gene expression through induction of suppressor of cytokine signaling-3

31 March 2020

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Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumor necrosis factor alpha and nitric oxide production by macrophages

31 March 2020

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Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex

31 March 2020

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Involvement of suppressors of cytokine signaling in toll-like receptor-mediated block of dendritic cell differentiation

31 March 2020

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Dendritic cell maturation requires STAT1 and is under feedback regulation by suppressors of cytokine signaling

31 March 2020

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The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8alpha+ dendritic cell subset

31 March 2020

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Suppressor of Cytokine Signaling-1 Is Essential for Suppressing Dendritic Cell Activation and Systemic Autoimmunity

31 March 2020

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Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity

31 March 2020

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An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells

31 March 2020

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SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling

31 March 2020

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Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo

31 March 2020

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Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1

31 March 2020

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Target cell defense prevents the development of diabetes after viral infection.

31 March 2020

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The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury

31 March 2020

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The lack of suppressor of cytokine signalling-1 (SOCS1) protects mice from the development of cerebral malaria caused by Plasmodium berghei ANKA.

31 March 2020

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Induction of suppressor of cytokine signaling-1 by Toxoplasma gondii contributes to immune evasion in macrophages by blocking IFN-gamma signaling

31 March 2020

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Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling

31 March 2020

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Cytokine signal transduction is suppressed in preselection double-positive thymocytes and restored by positive selection

31 March 2020

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Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells.

31 March 2020

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Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation.

31 March 2020

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Suppressor of Cytokine Signaling-1 Has IFN- -Independent Actions in T Cell Homeostasis

31 March 2020

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Suppressor of cytokine signaling 1 stringently regulates distinct functions of IL-7 and IL-15 in vivo during T lymphocyte development and homeostasis.

31 March 2020

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Suppressor of cytokine signaling 1 regulates IL-15 receptor signaling in CD8+CD44high memory T lymphocytes.

31 March 2020

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SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential

31 March 2020

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A regulatory role for suppressor of cytokine signaling-1 in T(h) polarization in vivo

31 March 2020

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Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance

31 March 2020

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SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.

31 March 2020

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SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor β2 subunit

31 March 2020

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Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression

31 March 2020

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The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model

31 March 2020

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Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1

31 March 2020

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Functional Polymorphism in theSuppressor of Cytokine Signaling 1Gene Associated with Adult Asthma

31 March 2020

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

31 March 2020

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

31 March 2020

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Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

31 March 2020

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SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis

31 March 2020

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Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

31 March 2020

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Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.

31 March 2020

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

31 March 2020

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Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

31 March 2020

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Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice

31 March 2020

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Nucleophosmin/anaplastic lymphoma kinase (NPM/ALK) oncoprotein induces the T regulatory cell phenotype by activating STAT3

31 March 2020

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Th17: an effector CD4 T cell lineage with regulatory T cell ties

31 March 2020

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Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation

31 March 2020

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Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line

31 March 2020

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v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells.

31 March 2020

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Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR/ABL-negative myeloproliferative disorders.

31 March 2020

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Signal transduction of inflammatory cytokines and tumor development

31 March 2020

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Aberrant Promoter Methylation Profiles of Tumor Suppressor Genes in Hepatocellular Carcinoma

31 March 2020

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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

31 March 2020

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Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.

31 March 2020

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Defective Hepatic Response to Interferon and Activation of Suppressor of Cytokine Signaling 3 in Chronic Hepatitis C

31 March 2020

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Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis

31 March 2020

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Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis

31 March 2020

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Treatment of mice with the suppressor of cytokine signaling-1 mimetic peptide, tyrosine kinase inhibitor peptide, prevents development of the acute form of experimental allergic encephalomyelitis and induces stable remission in the chronic relapsing

31 March 2020

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A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells.

31 March 2020

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Single-walled carbon nanotubes-mediated in vivo and in vitro delivery of siRNA into antigen-presenting cells

31 March 2020

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Role of suppressors of cytokine signaling SOCS-1 and SOCS-3 in hepatic steatosis and the metabolic syndrome

31 March 2020

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Control mechanism of JAK/STAT signal transduction pathway

31 March 2020

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Computer simulation of the role of SOCS family protein in helper T cell differentiation.

31 March 2020

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A network model for the control of the differentiation process in Th cells

31 March 2020

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Human immunodeficiency virus 1 Nef suppresses CD40-dependent immunoglobulin class switching in bystander B cells.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI2093

1 reference

16 August 2017

1 reference

PubMed ID

17525754