(Q36836598)

16 August 2017

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title

Interfering with disease: a progress report on siRNA-based therapeutics (English)

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16 August 2017

author

Hans-Peter Vornlocher

2

object named as

Hans-Peter Vornlocher

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16 August 2017

author name string

Antonin de Fougerolles

1

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16 August 2017

John Maraganore

3

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16 August 2017

Judy Lieberman

4

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16 August 2017

publication date

1 June 2007

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Nature Reviews Drug Discovery

16 August 2017

published in

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16 August 2017

volume

6

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16 August 2017

issue

6

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16 August 2017

page(s)

443-453

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

16 August 2017

cites work

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

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Mechanisms of gene silencing by double-stranded RNA

21 January 2018

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Strategies for silencing human disease using RNA interference

21 January 2018

1 reference

MicroRNAs: small RNAs with a big role in gene regulation

21 January 2018

1 reference

Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

21 January 2018

1 reference

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies

21 January 2018

1 reference

A microRNA in a multiple-turnover RNAi enzyme complex

21 January 2018

1 reference

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

21 January 2018

1 reference

On the art of identifying effective and specific siRNAs

21 January 2018

1 reference

Rational siRNA design for RNA interference

21 January 2018

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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

21 January 2018

1 reference

Asymmetry in the assembly of the RNAi enzyme complex

21 January 2018

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Functional siRNAs and miRNAs Exhibit Strand Bias

21 January 2018

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Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

21 January 2018

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Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

21 January 2018

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A computational study of off-target effects of RNA interference

21 January 2018

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Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 January 2018

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3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

21 January 2018

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Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 January 2018

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Off-target effects by siRNA can induce toxic phenotype

21 January 2018

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siRNA and isRNA: two edges of one sword

21 January 2018

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Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

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Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

21 January 2018

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In vivo activity of nuclease-resistant siRNAs

21 January 2018

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Chemical modification of siRNAs to improve serum stability without loss of efficacy.

21 January 2018

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Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

21 January 2018

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Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

21 January 2018

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Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging

21 January 2018

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In situ analysis of single-stranded and duplex siRNA integrity in living cells

21 January 2018

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RNAi therapeutics: a potential new class of pharmaceutical drugs

21 January 2018

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Intravitreal injection of vascular endothelial growth factor small interfering RNA inhibits growth and leakage in a nonhuman primate, laser-induced model of choroidal neovascularization

21 January 2018

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Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.

21 January 2018

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Inhibition of respiratory viruses by nasally administered siRNA.

21 January 2018

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Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque

21 January 2018

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Small interfering RNA targeting heme oxygenase-1 enhances ischemia-reperfusion-induced lung apoptosis.

21 January 2018

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In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury

21 January 2018

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Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis

21 January 2018

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Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death

21 January 2018

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Suppression of discoidin domain receptor 1 by RNA interference attenuates lung inflammation

21 January 2018

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Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake

21 January 2018

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Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

21 January 2018

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siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain

21 January 2018

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siRNA relieves chronic neuropathic pain

21 January 2018

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An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons

21 January 2018

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Gene knockdown with intrathecal siRNA of NMDA receptor NR2B subunit reduces formalin-induced nociception in the rat.

21 January 2018

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Targeted delivery of oligodeoxynucleotides to parenchymal liver cells in vivo.

21 January 2018

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

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Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells.

21 January 2018

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Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

21 January 2018

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Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

21 January 2018

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Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

21 January 2018

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Aptamer mediated siRNA delivery

21 January 2018

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Aptamers: an emerging class of therapeutics

21 January 2018

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Recent approaches to intracellular delivery of drugs and DNA and organelle targeting

21 January 2018

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RNAi-mediated gene silencing in non-human primates.

21 January 2018

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Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

21 January 2018

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Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference

21 January 2018

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Inhibition of HPV 16 E6 oncogene expression by RNA interference in vitro and in vivo

21 January 2018

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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

21 January 2018

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Prospects for cationic polymers in gene and oligonucleotide therapy against cancer

21 January 2018

1 reference

GALA: a designed synthetic pH-responsive amphipathic peptide with applications in drug and gene delivery

21 January 2018

1 reference

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine

21 January 2018

1 reference

Inhibition of influenza virus production in virus-infected mice by RNA interference

21 January 2018

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RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts

21 January 2018

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RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

21 January 2018

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Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung

21 January 2018

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Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro.

21 January 2018

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A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes

21 January 2018

1 reference

A versatile reducible polycation-based system for efficient delivery of a broad range of nucleic acids

21 January 2018

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RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.

21 January 2018

1 reference

Intravenous delivery of anti-RhoA small interfering RNA loaded in nanoparticles of chitosan in mice: safety and efficacy in xenografted aggressive breast cancer

21 January 2018

1 reference

Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA.

21 January 2018

1 reference

A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics

21 January 2018

1 reference

Therapeutic potential of RNA interference against cancer

21 January 2018

1 reference

Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies.

21 January 2018

1 reference

Tat-conjugated PAMAM dendrimers as delivery agents for antisense and siRNA oligonucleotides

21 January 2018

1 reference

Conjugates of oligonucleotides and analogues with cell penetrating peptides as gene silencing agents

21 January 2018

1 reference

Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells

21 January 2018

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Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.

21 January 2018

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Effective targeting of liposomes to liver and hepatocytes in vivo by incorporation of a Plasmodium amino acid sequence

21 January 2018

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Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1.

21 January 2018

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Pegaptanib for neovascular age-related macular degeneration

21 January 2018

1 reference

RNA interference targeting Fas protects mice from fulminant hepatitis

21 January 2018

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Induction of the interferon response by siRNA is cell type- and duplex length-dependent

31 March 2020

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Designing siRNA that distinguish between genes that differ by a single nucleotide

31 March 2020

1 reference

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

31 March 2020

1 reference

RNA interference in vivo: toward synthetic small inhibitory RNA-based therapeutics

31 March 2020

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Different delivery methods-different expression profiles

31 March 2020

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Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs

31 March 2020

1 reference

City initiative: baby steps to a better future.

31 March 2020

1 reference

Target-specific gene silencing by siRNA plasmid DNA complexed with folate-modified poly(ethylenimine).

31 March 2020

1 reference

Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor alpha in experimental arthritis

31 March 2020

1 reference

siRNA-induced caveolin-1 knockdown in mice increases lung vascular permeability via the junctional pathway

31 March 2020

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Engineering mucosal RNA interference in vivo

31 March 2020

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Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes

31 March 2020

1 reference

Cholesteryl oligoarginine delivering vascular endothelial growth factor siRNA effectively inhibits tumor growth in colon adenocarcinoma

31 March 2020

1 reference

Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors

31 March 2020

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Fomivirsen for the treatment of cytomegalovirus retinitis

31 March 2020

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Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model.

31 March 2020

1 reference

12 December 2020

A single siRNA suppresses fatal encephalitis induced by two different flaviviruses

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12 December 2020

RNA interference targeting transforming growth factor-beta type II receptor suppresses ocular inflammation and fibrosis.

1 reference

12 December 2020

Lipid-based nanoparticles for nucleic acid delivery

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12 December 2020

Peptide-oligonucleotide conjugates for the delivery of antisense and siRNA.

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12 December 2020

Identifiers

DOI

10.1038/NRD2310

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16 August 2017

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