(Q36857756)

16 August 2017

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title

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data (English)

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16 August 2017

1 reference

ChEBI release 2020-05-28

Iwatsubo T

1

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16 August 2017

Hirota N

2

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16 August 2017

Ooie T

3

1 reference

16 August 2017

Suzuki H

4

1 reference

16 August 2017

Shimada N

5

1 reference

16 August 2017

Chiba K

6

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16 August 2017

Ishizaki T

7

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16 August 2017

Green CE

8

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16 August 2017

Tyson CA

9

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16 August 2017

Sugiyama Y

10

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16 August 2017

1 January 1997

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Pharmacology & Therapeutics

16 August 2017

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16 August 2017

73

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16 August 2017

147-171

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16 August 2017

2

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Models of hepatic drug clearance: discrimination between the ‘well stirred’ and ‘parallel-tube’ models

16 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Physiologically based models and strategic experiments in hepatic pharmacology

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Hepatic elimination of flowing substrates: the distributed model

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Prediction of intrinsic clearance of loxtidine from kinetic studies in rat, dog and human hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Methotrexate Pharmacokinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Interspecies variation in liver weight, hepatic blood flow, and antipyrine intrinsic clearance: Extrapolation of data to benzodiazepines and phenytoin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Interspecies scaling, allometry, physiological time, and the ground plan of pharmacokinetics.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Clinical pharmacokinetics of imipramine and desipramine in alcoholics and normal volunteers

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

1 reference

7 January 2021

Pharmacokinetics of 1-beta-D-arabinofuranosylcytosine (ARA-C) deamination in several species.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Human adult hepatocytes in primary monolayer culture

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Stereoselective protein binding of verapamil enantiomers

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Predicting the hepatic clearance of xenobiotics in humans from in vitro data

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Metoprolol and mephenytoin oxidation polymorphisms in Far Eastern Oriental subjects: Japanese versus mainland Chinese

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Identification of the cytochrome P450 IIIA family as the enzymes involved in the N-demethylation of tamoxifen in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Correlation between in vitro and in vivo drug metabolism rate: oxidation of ethoxybenzamide in rat

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Kinetic studies on the deethylation of ethoxybenzamide. A comparative study with isolated hepatocytes and liver microsomes of rat

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Excretion of tolbutamide metabolites in young and old subjects

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Pharmacokinetics of intravenous theophylline

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Computer simulation of sulfobromophthalein kinetics in the rat using flow-limited models with extrapolation to man

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

The influence of the interdigestive migrating myoelectric complex on the gastric emptying of liquids

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Pharmacokinetics of oral mexiletine in patients with acute myocardial infarction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Theophylline disposition in patients with hepatic cirrhosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

The effect of age on the pharmacokinetics of metoprolol and its metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

On the pharmacokinetics of phenacetin in man

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Pharmacokinetic studies on the selective beta1-receptor antagonist metoprolol in man.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

The effects of hemodilution, pH, and protamine on lidocaine plasma protein binding and red blood-cell uptake in vitro.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Expression of human liver cytochrome P450 IIIA4 in yeast. A functional model for the hepatic enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Interspecies variability in mitoxantrone metabolism using primary cultures of hepatocytes isolated from rat, rabbit and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Correlation between in-vitro microsomal enzyme activity and whole organ hepatic elimination kinetics: analysis with a dispersion model

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Models of hepatic elimination: Comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Characterisation of theophylline metabolism in human liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Clearance concepts in pharmacokinetics

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Prediction of the disposition of beta-lactam antibiotics in humans from pharmacokinetic parameters in animals

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Influence of smoking and gender on the disposition kinetics of metoprolol

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Physiological disposition of verapamil in man

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Comparative drug metabolism of diazepam in hepatocytes isolated from man, rat, monkey and dog.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Pharmacokinetics and pharmacodynamics of alprazolam after oral and IV administration

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Factors affecting the metabolism of phenacetin. I. Influence of dose, chronic dosage, route of administration and species on the metabolism of (1-14C-acetyl)phenacetin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Applications and prospects for physiologically based pharmacokinetic (PB-PK) models involving pharmaceutical agents

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Drug absorption and metabolism studies by use of portal vein infusion in the rat. II. Influence of dose and infusion rate on the bioavailability of propranolol

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

The warfarin-sulfinpyrazone interaction: stereochemical considerations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Erythrocyte and serum distribution of mexiletine in man

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Studies on the disposition of antipyrine, aminopyrine, and phenacetin using plasma, saliva, and urine.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Alprazolam metabolism in vitro: studies of human, monkey, mouse, and rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Commentary: a physiological approach to hepatic drug clearance

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Influence of acute viral hepatitis on disposition and plasma binding of tolbutamide

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Lidocaine disposition--sex differences and effects of cimetidine.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2896%2900184-2

7 January 2021

10.1016/S0163-7258(96)00184-2

Identifiers

DOI

1 reference

16 August 2017

1 reference