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Conformational complexity of G-protein-coupled receptors

scientific article published on 13 July 2007

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Europe PubMed Central

16 August 2017

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Europe PubMed Central

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Conformational complexity of G-protein-coupled receptors (English)

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Europe PubMed Central

16 August 2017

G protein-coupled receptor

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G protein-coupled receptor signaling in absence of ligand

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Gene Ontology release 2020-05-02

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Brian K Kobilka

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Europe PubMed Central

16 August 2017

Xavier Deupi

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publication date

13 July 2007

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Europe PubMed Central

16 August 2017

Trends in Pharmacological Sciences

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Europe PubMed Central

16 August 2017

28

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Europe PubMed Central

16 August 2017

397-406

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Europe PubMed Central

16 August 2017

8

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Europe PubMed Central

16 August 2017

Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

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11 October 2022

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Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

1 reference

11 October 2022

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The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling

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The neurokinin A receptor activates calcium and cAMP responses through distinct conformational states

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Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

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Transduction of receptor signals by beta-arrestins

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Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

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Ligand-selective receptor conformations revisited: the promise and the problem

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Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

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The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate

1 reference

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Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop

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Lessons from constitutively active mutants of G protein-coupled receptors

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Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state

1 reference

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Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

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Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

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Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation.

1 reference

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The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII.

1 reference

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Structural domains of the CB1 cannabinoid receptor that contribute to constitutive activity and G-protein sequestration.

1 reference

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Crystal structure of rhodopsin: A G protein-coupled receptor

1 reference

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Efficacy at G-protein-coupled receptors

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Generation and analysis of constitutively active and physically destabilized mutants of the human beta(1)-adrenoceptor

1 reference

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Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

1 reference

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Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor

1 reference

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The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

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Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

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The Energy Landscapes and Motions of Proteins

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Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

1 reference

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The active state of the AT1 angiotensin receptor is generated by angiotensin II induction

1 reference

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Agonist binding: a multistep process.

1 reference

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Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.

1 reference

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Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

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10.1016/J.TIPS.2007.06.003

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stated in

Europe PubMed Central

16 August 2017

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Europe PubMed Central

PubMed ID

17629961

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16 August 2017

ResearchGate publication ID

6208195

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(Q36880905)

Conformational complexity of G-protein-coupled receptors

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