(Q36910081)

17 August 2017

1 reference

title

Xenobiotic transporters: ascribing function from gene knockout and mutation studies (English)

1 reference

17 August 2017

Curtis D Klaassen

1

1 reference

PubMed ID

17698509

17 August 2017

Hong Lu

series ordinal

2

1 reference

17 August 2017

13 August 2007

1 reference

17 August 2017

Toxicological Sciences

1 reference

17 August 2017

101

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17 August 2017

186-196

1 reference

17 August 2017

2

1 reference

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption

17 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Mouse zinc transporter 1 gene provides an essential function during early embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Biology of a novel organic solute and steroid transporter, OSTalpha-OSTbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

ATP7B mediates vesicular sequestration of copper: insight into biliary copper excretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Effect of phosphate transporter and methylation inhibitor drugs on the disposition of arsenate and arsenite in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Mechanisms of disease: psychomotor retardation and high T3 levels caused by mutations in monocarboxylate transporter 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Intestinal drug transporter expression and the impact of grapefruit juice in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

The hepatocellular bile acid transporter Ntcp facilitates uptake of the lethal mushroom toxin ?-amanitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Dietary plant sterols accumulate in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Targeted ablation of the abcc6 gene results in ectopic mineralization of connective tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Carnitine transport by organic cation transporters and systemic carnitine deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

ABCG5 and ABCG8 require MDR2 for secretion of cholesterol into bile

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

The presence of xenobiotic transporters in rat placenta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Mrp4 confers resistance to topotecan and protects the brain from chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Functional characteristics and pharmacokinetic significance of kidney-specific organic anion transporters, OAT-K1 and OAT-K2, in the urinary excretion of anionic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Identification of phalloidin uptake systems of rat and human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Role and relevance of peptide transporter 2 (PEPT2) in the kidney and choroid plexus: in vivo studies with glycylsarcosine in wild-type and PEPT2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

A human transporter protein that mediates the final excretion step for toxic organic cations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Intestinal absorption of cadmium is associated with divalent metal transporter 1 in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Identification and characterization of novel rat and human gonad-specific organic anion transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Involvement of multispecific organic anion transporter, Oatp14 (Slc21a14), in the transport of thyroxine across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Severe cholestasis induced by cholic acid feeding in knockout mice of sister of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM214

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFM214

1 reference

17 August 2017

1 reference

PubMed ID

17698509