(Q37114139)

18 August 2017

1 reference

title

Protein-protein interactions as targets for small-molecule therapeutics in cancer (English)

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protein-protein interaction

18 August 2017

main subject

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Alex W White

1

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18 August 2017

Andrew D Westwell

series ordinal

2

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18 August 2017

Ghali Brahemi

series ordinal

3

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18 August 2017

publication date

19 March 2008

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Expert Reviews in Molecular Medicine

18 August 2017

published in

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18 August 2017

volume

10

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18 August 2017

page(s)

e8

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Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

18 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

The inhibitors of apoptosis (IAPs) as cancer targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Small molecule inhibitors of the XIAP protein-protein interaction

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399408000641

Herceptin: mechanisms of action and resistance

21 January 2018

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Exploring protein-protein interactions with phage display

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399408000641

Unraveling hot spots in binding interfaces: progress and challenges

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399408000641

The atomic structure of protein-protein recognition sites

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399408000641

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399408000641

Luxury accommodations: the expanding role of structural plasticity in protein-protein interactions

21 January 2018

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https://api.crossref.org/works/10.1017%2FS1462399408000641

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Computational identification of inhibitors of protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Inhibiting transient protein-protein interactions: lessons from the Cdc25 protein tyrosine phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Anatomy of hot spots in protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

New approaches to molecular cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Structural basis for the inhibition of caspase-3 by XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Structural basis of caspase-7 inhibition by XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Promoting apoptosis as a strategy for cancer drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

How the Bcl-2 family of proteins interact to regulate apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Apoptosis-based therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Drugs targeting protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Strategies for targeting protein-protein interactions with synthetic agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Targeting protein-protein interactions for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Protein-protein interactions and cancer: small molecules going in for the kill

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Protein-protein interactions: lessons learned

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Inhibition of protein-protein association by small molecules: approaches and progress

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

21 January 2018

Bcl-2 family proteins

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Functions of the p53 Protein in Growth Regulation and Tumor Suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

p53 Activation by small molecules: application in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Expression of exogenous wt-p53 does not affect normal hematopoiesis: implications for bone marrow purging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Functions of the MDM2 oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Decision making by p53: life, death and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Dangerous habits of a security guard: the two faces of p53 as a drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Twenty years of p53 research: structural and functional aspects of the p53 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

p53, the cellular gatekeeper for growth and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Antimicrotubular drugs binding to vinca domain of tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Localization of the vinblastine-binding site on beta-tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Negatively stained vinblastine aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Mining the Wnt pathway for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Targeting Ras and Rho GTPases as opportunities for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Macrocyclization in the design of Grb2 SH2 domain-binding ligands exhibiting high potency in whole-cell systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Localization of the colchicine-binding site of tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Structural insight into microtubule function

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Structural basis for specificity of Grb2-SH2 revealed by a novel ligand binding mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Anticancer therapy with novel tubulin-interacting drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Modulation of protein-protein interactions by stabilizing/mimicking protein secondary structure elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Mechanism of action of antitumor drugs that interact with microtubules and tubulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

SH2 domain inhibition: a problem solved?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Potential disease targets for drugs that disrupt protein-- protein interactions of Grb2 and Crk family adaptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Recent advances in understanding apoptosis: new therapeutic opportunities in cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

Structure-based design and synthesis of high affinity tripeptide ligands of the Grb2-SH2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

7 January 2021

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

7 January 2021

New insights into microtubule structure and function from the atomic model of tubulin

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

7 January 2021

Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

7 January 2021

Identification of cysteine 354 of beta-tubulin as part of the binding site for the A ring of colchicine

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

7 January 2021

Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model

1 reference

https://api.crossref.org/works/10.1017%2FS1462399408000641

7 January 2021

10.1017/S1462399408000641

Identifiers

DOI

1 reference

18 August 2017

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