(Q37119697)

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Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer

scientific article published on 06 May 2016

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scholarly article

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Europe PubMed Central

18 August 2017

Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer (English)

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18 August 2017

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inferred from title

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5 June 2020

Konstantinos V Floros

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5 June 2020

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5 June 2020

Masaharu Nishimura

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5 June 2020

author name string

Hidenori Kitai

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5 June 2020

Shuta Tomida

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5 June 2020

Yuta Adachi

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5 June 2020

Satoshi Oizumi

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5 June 2020

Anthony C Faber

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5 June 2020

Seiji Yano

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publication date

6 May 2016

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18 August 2017

Cancer Discovery

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5 June 2020

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5 June 2020

754-769

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5 June 2020

7

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5 June 2020

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road

1 reference

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1 reference

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Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

1 reference

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1 reference

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RAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?

1 reference

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1 reference

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The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

1 reference

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Drugging the undruggable RAS: Mission possible?

1 reference

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KRAS and YAP1 converge to regulate EMT and tumor survival

1 reference

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14 September 2017

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

1 reference

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14 September 2017

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

1 reference

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14 September 2017

Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers

1 reference

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Dragging ras back in the ring

1 reference

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14 September 2017

Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation

1 reference

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14 September 2017

Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers

1 reference

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14 September 2017

Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

1 reference

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14 September 2017

Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer

1 reference

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14 September 2017

Relief of feedback inhibition of HER3 transcription by RAF and MEK inhibitors attenuates their antitumor effects in BRAF-mutant thyroid carcinomas.

1 reference

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Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas

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FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.

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Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

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EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

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Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome

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Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

1 reference

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1 reference

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1 reference

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3 September 2018

Identifiers

10.1158/2159-8290.CD-15-1377

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27154822%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

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Europe PubMed Central

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5 June 2020

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Europe PubMed Central

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5 June 2020

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