(Q37145878)

18 August 2017

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title

Mechanisms of asymmetric cell division: flies and worms pave the way. (English)

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18 August 2017

asymmetric cell division

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1

Pierre Gönczy

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publication date

1 May 2008

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Nature Reviews Molecular Cell Biology

18 August 2017

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18 August 2017

9

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18 August 2017

355-366

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18 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrm2388

18 August 2017

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cites work

Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo

1 reference

Sequential functioning of the ECT-2 RhoGEF, RHO-1 and CDC-42 establishes cell polarity in Caenorhabditis elegans embryos.

31 March 2020

1 reference

CDC-42 and RHO-1 coordinate acto-myosin contractility and PAR protein localization during polarity establishment in C. elegans embryos.

31 March 2020

1 reference

CYK-4/GAP provides a localized cue to initiate anteroposterior polarity upon fertilization.

31 March 2020

1 reference

The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote

31 March 2020

1 reference

Centrosome maturation and mitotic spindle assembly in C. elegans require SPD-5, a protein with multiple coiled-coil domains

31 March 2020

1 reference

Cyclin E-Cdk2 temporally regulates centrosome assembly and establishment of polarity in Caenorhabditis elegans embryos.

31 March 2020

1 reference

Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos

31 March 2020

1 reference

Zyg-11 and cul-2 regulate progression through meiosis II and polarity establishment in C. elegans.

31 March 2020

1 reference

Microtubules are involved in anterior-posterior axis formation in C. elegans embryos

31 March 2020

1 reference

Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos.

31 March 2020

1 reference

Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases

31 March 2020

1 reference

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

31 March 2020

1 reference

The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo

31 March 2020

1 reference

Stabilization of cell polarity by the C. elegans RING protein PAR-2.

31 March 2020

1 reference

An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotes

31 March 2020

1 reference

A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans

31 March 2020

1 reference

The nonmuscle myosin regulatory light chain gene mlc-4 is required for cytokinesis, anterior-posterior polarity, and body morphology during Caenorhabditis elegans embryogenesis

31 March 2020

1 reference

C. elegans PAR proteins function by mobilizing and stabilizing asymmetrically localized protein complexes

31 March 2020

1 reference

Depletion of the co-chaperone CDC-37 reveals two modes of PAR-6 cortical association in C. elegans embryos.

31 March 2020

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CDC-42 controls early cell polarity and spindle orientation in C. elegans.

31 March 2020

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Interaction of PAR-6 with CDC-42 is required for maintenance but not establishment of PAR asymmetry in C. elegans

31 March 2020

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Translational regulation and RNA localization in Drosophila oocytes and embryos.

31 March 2020

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Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradation

31 March 2020

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The prospero gene specifies cell fates in the drosophila central nervous system

31 March 2020

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prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila

31 March 2020

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Asymmetric segregation of the homeodomain protein Prospero during Drosophila development.

31 March 2020

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Asymmetric segregation of Numb and Prospero during cell division.

31 March 2020

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Miranda mediates asymmetric protein and RNA localization in the developing nervous system

31 March 2020

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Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate.

31 March 2020

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The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila.

31 March 2020

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Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.

31 March 2020

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Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal.

31 March 2020

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numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

31 March 2020

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Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors

31 March 2020

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Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

31 March 2020

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Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.

31 March 2020

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Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts

31 March 2020

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Quantitative analysis of protein dynamics during asymmetric cell division.

31 March 2020

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Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport

31 March 2020

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Miranda directs Prospero to a daughter cell during Drosophila asymmetric divisions

31 March 2020

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Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila

31 March 2020

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The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts.

31 March 2020

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Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila

31 March 2020

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Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts

31 March 2020

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Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts

31 March 2020

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Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.

31 March 2020

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DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila

31 March 2020

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Rapsynoid/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila.

31 March 2020

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A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila

31 March 2020

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Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization.

31 March 2020

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Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system

31 March 2020

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Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions.

31 March 2020

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31 March 2020

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The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division

31 March 2020

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Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization

31 March 2020

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Role of inscuteable in orienting asymmetric cell divisions in Drosophila

31 March 2020

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The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts

31 March 2020

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Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions.

31 March 2020

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Distinct roles of Galphai and Gbeta13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions

31 March 2020

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Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast

31 March 2020

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Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae.

31 March 2020

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The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl.

31 March 2020

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The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain

31 March 2020

1 reference

Flamingo controls the planar polarity of sensory bristles and asymmetric division of sensory organ precursors in Drosophila.

31 March 2020

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Two types of asymmetric divisions in the Drosophila sensory organ precursor cell lineage

31 March 2020

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The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila

31 March 2020

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The planar cell polarity protein Strabismus promotes Pins anterior localization during asymmetric division of sensory organ precursor cells in Drosophila.

31 March 2020

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tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS.

31 March 2020

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Translational repression determines a neuronal potential in Drosophila asymmetric cell division

31 March 2020

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Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage

31 March 2020

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The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila

31 March 2020

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Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs

31 March 2020

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Requirement for dynamin during Notch signaling in Drosophila neurogenesis.

31 March 2020

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Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway.

31 March 2020

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Unequal segregation of Neuralized biases Notch activation during asymmetric cell division.

31 March 2020

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Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta

31 March 2020

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neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis.

31 March 2020

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Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system.

31 March 2020

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Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo

31 March 2020

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The distribution of active force generators controls mitotic spindle position

31 March 2020

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Microtubule depolymerization promotes particle and chromosome movement in vitro

31 March 2020

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Minus-end-directed motion of kinesin-coated microspheres driven by microtubule depolymerization.

31 March 2020

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Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms

31 March 2020

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PAR proteins regulate microtubule dynamics at the cell cortex in C. elegans

31 March 2020

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Cortical microtubule contacts position the spindle in C. elegans embryos.

31 March 2020

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Identification and characterization of factors required for microtubule growth and nucleation in the early C. elegans embryo.

31 March 2020

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Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans.

31 March 2020

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Heterotrimeric G protein signaling functions with dynein to promote spindle positioning in C. elegans

31 March 2020

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Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators.

31 March 2020

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Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex.

31 March 2020

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The Aspergillus cytoplasmic dynein heavy chain and NUDF localize to microtubule ends and affect microtubule dynamics.

31 March 2020

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Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryos.

31 March 2020

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Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos

31 March 2020

1 reference

A complex of LIN-5 and GPR proteins regulates G protein signaling and spindle function inC. elegans

31 March 2020

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Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo

31 March 2020

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LIN-5 is a novel component of the spindle apparatus required for chromosome segregation and cleavage plane specification in Caenorhabditis elegans

31 March 2020

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Cortical localization of the Galpha protein GPA-16 requires RIC-8 function during C. elegans asymmetric cell division.

31 March 2020

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Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins

31 March 2020

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31 March 2020

Flies without centrioles

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RIC-8 is required for GPR-1/2-dependent Galpha function during asymmetric division of C. elegans embryos

31 March 2020

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LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling

31 March 2020

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Return of the GDI: the GoLoco motif in cell division.

31 March 2020

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RGS-7 completes a receptor-independent heterotrimeric G protein cycle to asymmetrically regulate mitotic spindle positioning in C. elegans

31 March 2020

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Control of embryonic spindle positioning and Galpha activity by C. elegans RIC-8.

31 March 2020

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Heterotrimeric G proteins: new tricks for an old dog.

31 March 2020

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Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins.

31 March 2020

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Cytoplasmic dynein is required for distinct aspects of MTOC positioning, including centrosome separation, in the one cell stage Caenorhabditis elegans embryo

31 March 2020

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Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation.

31 March 2020

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Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon.

31 March 2020

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Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.

31 March 2020

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Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster.

31 March 2020

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Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells

31 March 2020

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Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis

31 March 2020

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The orientation of cell division influences cell-fate choice in the developing mammalian retina

31 March 2020

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Mitotic spindle rotation and mode of cell division in the developing telencephalon

31 March 2020

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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases

31 March 2020

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Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis.

31 March 2020

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Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

31 March 2020

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Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors

31 March 2020

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Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis.

31 March 2020

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Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina

31 March 2020

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G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors

31 March 2020

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Control of planar divisions by the G-protein regulator LGN maintains progenitors in the chick neuroepithelium.

31 March 2020

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Defective planar cell polarity in polycystic kidney disease.

31 March 2020

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Asymmetric cell divisions promote stratification and differentiation of mammalian skin

31 March 2020

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The extracellular matrix guides the orientation of the cell division axis.

31 March 2020

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Does S. pombe exploit the intrinsic asymmetry of DNA synthesis to imprint daughter cells for mating-type switching?

31 March 2020

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Schizosaccharomyces pombe switches mating type by the synthesis-dependent strand-annealing mechanism

31 March 2020

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Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells.

31 March 2020

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Label-retaining epithelial cells in mouse mammary gland divide asymmetrically and retain their template DNA strands

31 March 2020

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Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro

31 March 2020

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Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes

31 March 2020

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Asymmetric inheritance of mother versus daughter centrosome in stem cell division

31 March 2020

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Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.

31 March 2020

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Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells.

31 March 2020

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A role for a novel centrosome cycle in asymmetric cell division

31 March 2020

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Dynamic localization of LIN-5 and GPR-1/2 to cortical force generation domains during spindle positioning

31 March 2020

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Yeast homologues of tomosyn and lethal giant larvae function in exocytosis and are associated with the plasma membrane SNARE, Sec9

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRM2388

1 reference

18 August 2017

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PubMed ID

18431399