(Q37149933)

18 August 2017

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title

eIF4E, the mRNA cap-binding protein: from basic discovery to translational research (English)

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18 August 2017

1

Nahum Sonenberg

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18 August 2017

1 April 2008

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Biochemistry and Cell Biology

18 August 2017

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18 August 2017

86

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18 August 2017

178-183

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18 August 2017

2

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mRNA cap-binding protein: cloning of the gene encoding protein synthesis initiation factor eIF-4E from Saccharomyces cerevisiae

18 August 2017

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4E-binding protein 1: a key molecular "funnel factor" in human cancer with clinical implications

21 January 2018

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The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus

21 January 2018

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Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression.

21 January 2018

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Cyanohydridoborate anion as a selective reducing agent

21 January 2018

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21 January 2018

mTOR and cancer therapy

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Differential synthesis of blocked and unblocked 5'-termini in reovirus mRNA: effect of pyrophosphate and pyrophosphatase

21 January 2018

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Reovirus messenger RNA contains a methylated, blocked 5'-terminal structure: m-7G(5')ppp(5')G-MpCp-

21 January 2018

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eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

21 January 2018

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

21 January 2018

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Regulation of translation initiation by FRAP/mTOR

21 January 2018

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Therapeutic suppression of translation initiation factor eIF4E expression reduces tumor growth without toxicity

21 January 2018

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Upstream and downstream of mTOR

21 January 2018

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IRF-7 is the master regulator of type-I interferon-dependent immune responses

21 January 2018

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A protein-nucleic acid crosslink in 30s ribosomes

21 January 2018

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Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors

21 January 2018

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The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts

21 January 2018

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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

21 January 2018

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Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

21 January 2018

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Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation

21 January 2018

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Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

21 January 2018

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5′-Terminal 7-methylguanosine in eukaryotic mRNA is required for translation

21 January 2018

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Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

21 January 2018

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mTOR signaling: implications for cancer and anticancer therapy

21 January 2018

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4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family

21 January 2018

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Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

21 January 2018

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Does the ribosome translate cancer?

21 January 2018

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

21 January 2018

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Amino acid sequence of the mRNA cap-binding protein from human tissues

21 January 2018

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Capping of eucaryotic mRNAs

21 January 2018

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Reovirus mRNA can be covalently crosslinked via the 5' cap to proteins in initiation complexes

21 January 2018

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A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA

21 January 2018

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Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP

21 January 2018

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Deregulation of the Akt pathway in human cancer

21 January 2018

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

21 January 2018

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Differential stimulation of capped mRNA translation in vitro by cap binding protein

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/O08-034

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18 August 2017

1 reference

PubMed ID

18443631