(Q37178657)

English

G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis

scientific article published on 07 April 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

G3139, an anti-Bcl-2 antisense oligomer that binds heparin-binding growth factors and collagen I, alters in vitro endothelial cell growth and tubular morphogenesis (English)

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

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1 reference

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author name string

C A Stein

1

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Sijian Wu

2

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Anatoliy M Voskresenskiy

3

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Jin-Feng Zhou

4

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Joongho Shin

5

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Paul Miller

6

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Naira Souleimanian

7

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Luba Benimetskaya

8

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Europe PubMed Central

PMC publication ID

18 August 2017

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publication date

7 April 2009

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Europe PubMed Central

PMC publication ID

18 August 2017

Clinical Cancer Research

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Europe PubMed Central

PMC publication ID

18 August 2017

15

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Europe PubMed Central

PMC publication ID

18 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

2797-2807

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

Angiogenesis alteration by defibrotide: implications for its mechanism of action in severe hepatic veno-occlusive disease

1 reference

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Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group

1 reference

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1 reference

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Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases

1 reference

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Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

1 reference

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Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

1 reference

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1 reference

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

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Oblimersen Bcl-2 antisense: facilitating apoptosis in anticancer treatment

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1 reference

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Fibroblast growth factors, their receptors and signaling

1 reference

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Blood flow influences vascular growth during tumour angiogenesis

1 reference

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A novel, quantitative model for study of endothelial cell migration and sprout formation within three-dimensional collagen matrices

1 reference

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Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis

1 reference

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Regulation of transcription by hypoxia requires a multiprotein complex that includes hypoxia-inducible factor 1, an adjacent transcription factor, and p300/CREB binding protein

1 reference

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Oligodeoxynucleotides interact with recombinant CD4 at multiple sites

1 reference

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Physical stabilization of acidic fibroblast growth factor by polyanions

1 reference

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

6 September 2017

Heparin and heparan sulfate increase the radius of diffusion and action of basic fibroblast growth factor

1 reference

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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1 reference

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6 September 2017

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells

1 reference

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Level of endothelial cell apoptosis required for a significant decrease in microvessel density.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

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A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

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G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

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Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.

1 reference

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Phosphorothioate oligodeoxynucleotides and G3139 induce apoptosis in 518A2 melanoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

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Relative Bcl-2 independence of drug-induced cytotoxicity and resistance in 518A2 melanoma cells.

1 reference

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1 reference

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Bcl-2 overexpression in human melanoma cells increases angiogenesis through VEGF mRNA stabilization and HIF-1-mediated transcriptional activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

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Cell-mediated delivery of fibroblast growth factor-2 and vascular endothelial growth factor onto the chick chorioallantoic membrane: endothelial fenestration and angiogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

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Fibroblast growth factor 2 activation of stromal cell vascular endothelial growth factor expression and angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

26 June 2018

Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

26 June 2018

Regulation by heparan sulfate in fibroblast growth factor signaling

1 reference

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26 June 2018

Importance of size and sulfation of heparin in release of basic fibroblast growth factor from the vascular endothelium and extracellular matrix

1 reference

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Chemoresistance of endothelial cells induced by basic fibroblast growth factor depends on Raf-1-mediated inhibition of the proapoptotic kinase, ASK1.

1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

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1 reference

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Fibroblast growth factor 2 promotes microvessel formation from mouse embryonic aorta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676857

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Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor.

1 reference

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Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression.

1 reference

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3 September 2018

Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells invitro: Implications for a role of heparinase-like enzymes in the neovascular response

1 reference

https://pubmed.ncbi.nlm.nih.gov/19351753

12 December 2020

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Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/19351753

12 December 2020

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Molecular and pharmacokinetic properties associated with the therapeutics of bcl-2 antisense oligonucleotide G3139 combined with free and liposomal doxorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19351753

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inferred from PubMed ID database lookup

Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19351753

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based on heuristic

inferred from PubMed ID database lookup

Distinct regulation of genes by bFGF and VEGF-A in endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19351753

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Identifiers

10.1158/1078-0432.CCR-08-2610

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

18 August 2017

ResearchGate publication ID

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