(Q37306482)

19 August 2017

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title

Beyond polymer polarity: how the cytoskeleton builds a polarized cell (English)

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19 August 2017

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Rong Li

1

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PubMed ID

18946475

19 August 2017

Gregg G Gundersen

series ordinal

2

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19 August 2017

1 November 2008

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Nature Reviews Molecular Cell Biology

19 August 2017

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19 August 2017

9

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19 August 2017

860-873

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19 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrm2522

19 August 2017

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Requirement of yeast fimbrin for actin organization and morphogenesis in vivo

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Formin-dependent actin assembly is regulated by distinct modes of Rho signaling in yeast

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Tropomyosin isoforms: divining rods for actin cytoskeleton function

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Differential regulation of skeletal muscle myosin-II and brush border myosin-I enzymology and mechanochemistry by bacterially produced tropomyosin isoforms.

31 March 2020

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Tropomyosin regulates elongation by formin at the fast-growing end of the actin filament.

31 March 2020

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Inhibition of the Arp2/3 complex-nucleated actin polymerization and branch formation by tropomyosin

31 March 2020

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The structural basis of actin filament branching by the Arp2/3 complex

31 March 2020

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Tropomyosin binding to F-actin protects the F-actin from disassembly by brain actin-depolymerizing factor (ADF).

31 March 2020

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Tropomyosin inhibits ADF/cofilin-dependent actin filament dynamics

31 March 2020

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A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

31 March 2020

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PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells

31 March 2020

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Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

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Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk

31 March 2020

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Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1.

31 March 2020

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Redox-dependent downregulation of Rho by Rac.

31 March 2020

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Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils

31 March 2020

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Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism

31 March 2020

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31 March 2020

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31 March 2020

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Neuronal polarity: from extracellular signals to intracellular mechanisms

31 March 2020

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Polarity proteins in axon specification and synaptogenesis

31 March 2020

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Individual microtubules in the axon consist of domains that differ in both composition and stability

31 March 2020

1 reference

The expression of acetylated microtubules during axonal and dendritic growth in cerebellar macroneurons which develop in vitro

31 March 2020

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Differential localisation of tyrosinated, detyrosinated, and acetylated alpha-tubulins in neurites and growth cones of dorsal root ganglion neurons

31 March 2020

1 reference

Microtubule stabilization specifies initial neuronal polarization

31 March 2020

1 reference

Centrosome localization determines neuronal polarity.

31 March 2020

1 reference

The role of local actin instability in axon formation

31 March 2020

1 reference

Cdc42 regulates cofilin during the establishment of neuronal polarity.

31 March 2020

1 reference

Asymmetric membrane ganglioside sialidase activity specifies axonal fate.

31 March 2020

1 reference

Neuronal polarity and the kinesin superfamily proteins

31 March 2020

1 reference

Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity

31 March 2020

1 reference

The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity

31 March 2020

1 reference

Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity

31 March 2020

1 reference

Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila.

31 March 2020

1 reference

Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity

31 March 2020

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MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

31 March 2020

1 reference

Interaction of kinesin motor domains with alpha- and beta-tubulin subunits at a tau-independent binding site. Regulation by polyglutamylation

31 March 2020

1 reference

Kinesin is a candidate for cross-bridging microtubules and intermediate filaments. Selective binding of kinesin to detyrosinated tubulin and vimentin

31 March 2020

1 reference

Export from pericentriolar endocytic recycling compartment to cell surface depends on stable, detyrosinated (glu) microtubules and kinesin.

31 March 2020

1 reference

Microtubule acetylation promotes kinesin-1 binding and transport.

31 March 2020

1 reference

A change in the selective translocation of the Kinesin-1 motor domain marks the initial specification of the axon.

31 March 2020

1 reference

Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head

31 March 2020

1 reference

MAP kinase dynamics in response to pheromones in budding yeast

31 March 2020

1 reference

Slow diffusion of proteins in the yeast plasma membrane allows polarity to be maintained by endocytic cycling

31 March 2020

1 reference

Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p

31 March 2020

1 reference

Harnessing actin dynamics for clathrin-mediated endocytosis

31 March 2020

1 reference

Opposing roles for actin in Cdc42p polarization

31 March 2020

1 reference

Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity

31 March 2020

1 reference

End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe.

31 March 2020

1 reference

Endocytosis: relation to capping and cell locomotion

31 March 2020

1 reference

From endocytosis to tumors through asymmetric cell division of stem cells.

31 March 2020

1 reference

Recycling endosomes of polarized epithelial cells actively sort apical and basolateral cargos into separate subdomains

31 March 2020

1 reference

Decreased polarity and increased random motility in PtK1 epithelial cells correlate with inhibition of endosomal recycling

31 March 2020

1 reference

Endocytic control of epithelial polarity and proliferation in Drosophila

31 March 2020

1 reference

The endocytic pathway acts downstream of Oskar in Drosophila germ plasm assembly.

31 March 2020

1 reference

Stimulation of endocytosis and actin dynamics by Oskar polarizes the Drosophila oocyte.

31 March 2020

1 reference

Genome-wide analysis identifies a general requirement for polarity proteins in endocytic traffic.

31 March 2020

1 reference

Tumor suppressor PTEN mediates sensing of chemoattractant gradients.

31 March 2020

1 reference

Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis

31 March 2020

1 reference

Regulation of microtubule-organizing center orientation and actomyosin cytoskeleton rearrangement during immune interactions

31 March 2020

1 reference

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42

31 March 2020

1 reference

Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

31 March 2020

1 reference

Recruitment of dynein to the Jurkat immunological synapse

31 March 2020

1 reference

Centrosome polarization delivers secretory granules to the immunological synapse.

31 March 2020

1 reference

Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta

31 March 2020

1 reference

Cdc42, dynein, and dynactin regulate MTOC reorientation independent of Rho-regulated microtubule stabilization

31 March 2020

1 reference

Par6alpha signaling controls glial-guided neuronal migration.

31 March 2020

1 reference

Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration

31 March 2020

1 reference

Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells

31 March 2020

1 reference

The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src

31 March 2020

1 reference

Selective stabilization of microtubules oriented toward the direction of cell migration

31 March 2020

1 reference

Rho guanosine triphosphatase mediates the selective stabilization of microtubules induced by lysophosphatidic acid

31 March 2020

1 reference

ACF7: an essential integrator of microtubule dynamics

31 March 2020

1 reference

mDia mediates Rho-regulated formation and orientation of stable microtubules

31 March 2020

1 reference

The formin mDia2 stabilizes microtubules independently of its actin nucleation activity

31 March 2020

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Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling

31 March 2020

1 reference

EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration

31 March 2020

1 reference

Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts

31 March 2020

1 reference

CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta

31 March 2020

1 reference

Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells

31 March 2020

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Membrane insertion at the leading edge of motile fibroblasts

31 March 2020

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Migrating fibroblasts perform polarized, microtubule-dependent exocytosis towards the leading edge

31 March 2020

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Microtubule organization and function in epithelial cells

31 March 2020

1 reference

Cadherin-mediated regulation of microtubule dynamics

31 March 2020

1 reference

aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development

31 March 2020

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APC is a component of an organizing template for cortical microtubule networks

31 March 2020

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Organization of vesicular trafficking in epithelia

31 March 2020

1 reference

Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells

31 March 2020

1 reference

Polarization-dependent selective transport to the apical membrane by KIF5B in MDCK cells

31 March 2020

1 reference

KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes

31 March 2020

1 reference

The role of three cytoplasmic fibers in BHK-21 cell motility. I. Microtubules and the effects of colchicine

31 March 2020

1 reference

Neutrophil microtubules suppress polarity and enhance directional migration

31 March 2020

1 reference

Microtubule disruption induces the formation of actin stress fibers and focal adhesions in cultured cells: possible involvement of the rho signal cascade.

31 March 2020

1 reference

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

31 March 2020

1 reference

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton

31 March 2020

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Microtubule targeting of substrate contacts promotes their relaxation and dissociation

31 March 2020

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Targeting, capture, and stabilization of microtubules at early focal adhesions

31 March 2020

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Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase

31 March 2020

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Melanophilin and myosin Va track the microtubule plus end on EB1

31 March 2020

1 reference

Dynamic microtubules lead the way for spindle positioning.

31 March 2020

1 reference

Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170

31 March 2020

1 reference

The formin mDia regulates GSK3beta through novel PKCs to promote microtubule stabilization but not MTOC reorientation in migrating fibroblasts

31 March 2020

1 reference

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility

31 March 2020

1 reference

CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex

31 March 2020

1 reference

Microtubules tethered at epithelial cell junctions by dynein facilitate efficient junction assembly

31 March 2020

1 reference

Dynein binds to beta-catenin and may tether microtubules at adherens junctions.

31 March 2020

1 reference

Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiae

31 March 2020

1 reference

Molecular linkage underlying microtubule orientation toward cortical sites in yeast

31 March 2020

1 reference

Positioning of the mitotic spindle by a cortical-microtubule capture mechanism

31 March 2020

1 reference

The cortical protein Num1p is essential for dynein-dependent interactions of microtubules with the cortex

31 March 2020

1 reference

CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast

31 March 2020

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Tea2p kinesin is involved in spatial microtubule organization by transporting tip1p on microtubules.

31 March 2020

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Fission yeast mod5p regulates polarized growth through anchoring of tea1p at cell tips

31 March 2020

1 reference

Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM2522

1 reference

19 August 2017

1 reference

PubMed ID

18946475