(Q37326534)

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From molecular fossils of bacterial hopanoids to the formation of isoprene units: discovery and elucidation of the methylerythritol phosphate pathway

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scholarly article

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Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

From molecular fossils of bacterial hopanoids to the formation of isoprene units: discovery and elucidation of the methylerythritol phosphate pathway (English)

1 reference

Europe PubMed Central

19 August 2017

1 reference

based on heuristic

inferred from title

author name string

Michel Rohmer

1

1 reference

Europe PubMed Central

19 August 2017

publication date

15 November 2008

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

43

1 reference

Europe PubMed Central

19 August 2017

1095-1107

1 reference

Europe PubMed Central

19 August 2017

12

1 reference

Europe PubMed Central

19 August 2017

https://scigraph.springernature.com/pub.10.1007/s11745-008-3261-7

0 references

Prokaryotic hopanoids: the biosynthesis of the bacteriohopane skeleton. Formation of isoprenic units from two distinct acetate pools and a novel type of carbon/carbon linkage between a triterpene and D-ribose

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenoid biosynthesis through the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) is a [4Fe-4S] protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nonequivalent labeling of the phytyl side chain of chlorophyll a in callus of the hornwort Anthoceros punctatus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Silver ion high pressure liquid chromatography provides unprecedented separation of sterols: application to the enzymatic formation of cholesta-5,8-dien-3 beta-ol

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chlorophyta exclusively use the 1-deoxyxylulose 5-phosphate/2-C-methylerythritol 4-phosphate pathway for the biosynthesis of isoprenoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hopanoid lipids compose the Frankia vesicle envelope, presumptive barrier of oxygen diffusion to nitrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Terpenoid biosynthesis from 1-deoxy-D-xylulose in higher plants by intramolecular skeletal rearrangement

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reconstitution of an apicoplast-localised electron transfer pathway involved in the isoprenoid biosynthesis of Plasmodium falciparum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenoid biosynthesis in plant chloroplasts via the MEP pathway: direct thylakoid/ferredoxin-dependent photoreduction of GcpE/IspG.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization of GcpE, an essential enzyme of the non-mevalonate pathway of isoprenoid biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sterol biosynthesis via cycloartenol and other biochemical features related to photosynthetic phyla in the amoeba Naegleria lovaniensis and Naegleria gruberi

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of the labdane diterpene marrubiin in Marrubium vulgare via a non-mevalonate pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of two new C30 sterols, (24E)-24-N-propylidenecholesterol and 24 epsilon-N-propylcholesterol, from a cultured marine Chrysophyte

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incorporation of 1-deoxy-D-xylulose into isoprene and phytol by higher plants and algae

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of mevalonate and glyceraldehyde 3-phosphate/pyruvate routes for isoprenoid biosynthesis in some gram-negative bacteria and mycobacteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Classification of Terpenoids according to the Methylerythritolphosphate or the Mevalonate Pathway with Natural (12)C/(13)C Isotope Ratios: Dynamic Allocation of Resources in Induced Plants We thank Dr. H. Bischoff (Bayer AG, Wuppertal) for cerivasta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenoid biosynthesis in higher plants and in Escherichia coli: on the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deoxyxylulose phosphate pathway of isoprenoid biosynthesis: studies on the mechanisms of the reactions catalyzed by IspG and IspH protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of beta-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prokaryotic triterpenoids. 2. 2 beta-Methylhopanoids from Methylobacterium organophilum and Nostoc muscorum, a new series of prokaryotic triterpenoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyanobacterial non-mevalonate pathway: (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase interacts with ferredoxin in Thermosynechococcus elongatus BP-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of novel C35 pentacyclic terpenes from Acetobacter xylinum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IspH protein of Escherichia coli: studies on iron-sulfur cluster implementation and catalysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side-chains of chlorophylls and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga Scenedesmus obliquus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Content and composition of hopanoids in Zymomonas mobilis under various growth conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate to 2C-methyl-D-erythritol 2,4-cyclodiphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrosoluble complexes of sterols, sterol esters and their precursors from Zea mays L.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of orientation of bacterial cellulose microfibrils by a novel terpenoid from Acetobacter xylinum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of 2-methyl-3-buten-2-ol emitted from needles of Pinus ponderosa via the non-mevalonate DOXP/MEP pathway of isoprenoid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prokaryotic hopanoids and other polyterpenoid sterol surrogates

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prokaryotic triterpenoids. New bacteriohopanetetrol cyclitol ethers from the methylotrophic bacterium Methylobacterium organophilum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and characterization of a gene from Escherichia coli encoding a transketolase-like enzyme that catalyzes the synthesis of D-1-deoxyxylulose 5-phosphate, a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The chemical mechanism of D-1-deoxyxylulose-5-phosphate reductoisomerase from Escherichia coli.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prokaryotic triterpenoids. 1. 3 beta-Methylhopanoids from Acetobacter species and Methylococcus capsulatus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fosmidomycin, a novel chemotherapeutic agent for malaria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deuterium-labelled isotopomers of 2-C-methyl-D-erythritol as tools for the elucidation of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of isoprenoids via the non-mevalonate pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

acs1 of Haemophilus influenzae type a capsulation locus region II encodes a bifunctional ribulose 5-phosphate reductase- CDP-ribitol pyrophosphorylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of terpenes: studies on 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible direct involvement of the active-site [4Fe-4S] cluster of the GcpE enzyme from Thermus thermophilus in the conversion of MEcPP

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-talk between the Cytosolic Mevalonate and the Plastidial Methylerythritol Phosphate Pathways in Tobacco Bright Yellow-2 Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenoid biosynthesis via the methylerythritol phosphate pathway. Mechanistic investigations of the 1-deoxy-D-xylulose 5-phosphate reductoisomerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A family of transketolases that directs isoprenoid biosynthesis via a mevalonate-independent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hopanoids are formed during transition from substrate to aerial hyphae in Streptomyces coelicolor A3(2).

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereochemical studies on the making and unmaking of isopentenyl diphosphate in different biological systems.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate-independent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of bacterial isoprenoid synthesis by fosmidomycin, a phosphonic acid-containing antibiotic

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenoid biosynthesis in chloroplasts via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate synthase (GcpE) from Arabidopsis thaliana is a [4Fe-4S] protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimethylallyl pyrophosphate is not the committed precursor of isopentenyl pyrophosphate during terpenoid biosynthesis from 1-deoxyxylulose in higher plants

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Sterols and their precursors in Astasia longa Pringsheim]

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenoid biosynthesis as a novel target for antibacterial and antiparasitic drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The action of the systemic fungicides tridemorph and fenpropimorph on sterol biosynthesis by the soil amoeba Acanthamoeba polyphaga

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LytB protein catalyzes the terminal step of the 2-C-methyl-D-erythritol-4-phosphate pathway of isoprenoid biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular evolution of biomembranes: structural equivalents and phylogenetic precursors of sterols

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the nonmevalonate terpene biosynthetic pathway: metabolic role of IspH (LytB) protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of terpenoids: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from tomato

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fosmidomycin, a new phosphonic acid antibiotic. Part II: 1. Human pharmacokinetics. 2. Preliminary early phase IIa clinical studies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the mevalonic acid pathway and the glyceraldehyde-pyruvate pathway in terpenoid biosynthesis of the liverworts Ricciocarpos natans and Conocephalum conicum

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenoid biosynthesis via the methylerythritol phosphate pathway: the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a [4Fe-4S] protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19011917

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11745-008-3261-7

1 reference

Europe PubMed Central

19 August 2017

1 reference

Europe PubMed Central

19 August 2017

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