(Q37333592)

19 August 2017

1 reference

title

LKB1; linking cell structure and tumor suppression (English)

1 reference

19 August 2017

A F Hezel

1

1 reference

PubMed ID

19029933

19 August 2017

N Bardeesy

series ordinal

2

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PubMed ID

19029933

19 August 2017

language of work or name

English

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publication date

1 November 2008

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19 August 2017

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19 August 2017

27

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19 August 2017

6908-6919

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19 August 2017

55

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https://scigraph.springernature.com/pub.10.1038/onc.2008.342

19 August 2017

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cites work

LKB1-dependent signaling pathways

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 somatic mutations in sporadic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 tumor suppressor protein: PARtaker in cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Genome-wide survey of protein kinases required for cell cycle progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Analysis of the LKB1-STRAD-MO25 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

The AMP-activated protein kinase cascade--a unifying system for energy control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Mammalian PAR-1 determines epithelial lumen polarity by organizing the microtubule cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Metformin and reduced risk of cancer in diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Dialogue between LKB1 and AMPK: a hot topic at the cellular pole

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

An investigation of the Peutz-Jeghers gene (LKB1) in sporadic breast and colon cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Very high risk of cancer in familial Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Peutz-Jeghers syndrome and management recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Frequency and spectrum of cancers in the Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

The Par-1/MARK family of protein kinases: from polarity to metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 modulates lung cancer differentiation and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Energy-dependent regulation of cell structure by AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Relative frequency and morphology of cancers in STK11 mutation carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 and AMPK maintain epithelial cell polarity under energetic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Peutz-Jeghers families unlinked to STK11/LKB1 gene mutations are highly predisposed to primitive biliary adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 (XEEK1) regulates Wnt signalling in vertebrate development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Lkb1 deficiency causes prostate neoplasia in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Peutz-Jeghers syndrome with ovarian sex cord tumor with annular tubules and cervical adenoma malignum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Prevention of pancreatic cancer induction in hamsters by metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Glucose metabolism and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

The LKB1 tumor suppressor negatively regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1/STRAD promotes axon initiation during neuronal polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Cancer and the Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

21 January 2018

Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Peutz-Jeghers syndrome: 78-year follow-up of the original family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 and AMPK in cell polarity and division

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

AMP-activated protein kinase regulates the assembly of epithelial tight junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

LKB1 protein expression in neuroendocrine tumors of the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Guidance on gastrointestinal surveillance for hereditary non-polyposis colorectal cancer, familial adenomatous polypolis, juvenile polyposis, and Peutz-Jeghers syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Polarity proteins in migration and invasion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Increased risk of cancer in the Peutz-Jeghers syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Identification of genes required for cytoplasmic localization in early C. elegans embryos

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

Feminizing Sertoli cell tumors in boys with Peutz-Jeghers syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.342

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.342

1 reference

19 August 2017

1 reference

PubMed ID

19029933