(Q37349647)

19 August 2017

1 reference

title

Tetraspanins: push and pull in suppressing and promoting metastasis (English)

1 reference

19 August 2017

Margot Zöller

1

1 reference

PubMed ID

19078974

19 August 2017

language of work or name

English

0 references

publication date

11 December 2008

1 reference

19 August 2017

Nature Reviews Cancer

1 reference

19 August 2017

9

1 reference

19 August 2017

40-55

1 reference

19 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc2543

19 August 2017

0 references

cites work

Appearance of new tetraspanin genes during vertebrate evolution.

1 reference

Tetraspanin Proteins Mediate Cellular Penetration, Invasion, and Fusion Events and Define a Novel Type of Membrane Microdomain

31 March 2020

1 reference

Tetraspanin microdomains in immune cell signalling and malignant disease.

31 March 2020

1 reference

Tetraspanin functions and associated microdomains

31 March 2020

1 reference

TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins

31 March 2020

1 reference

Gastrointestinal tumors: metastasis and tetraspanins

31 March 2020

1 reference

Itinerant exosomes: emerging roles in cell and tissue polarity

31 March 2020

1 reference

KAI1 tetraspanin and metastasis suppressor.

31 March 2020

1 reference

CD82 metastasis suppressor gene: a potential target for new therapeutics?

31 March 2020

1 reference

KAI1/CD82, a tumor metastasis suppressor

31 March 2020

1 reference

Functional implications of tetraspanin proteins in cancer biology

31 March 2020

1 reference

Tetraspanins as regulators of protein trafficking

31 March 2020

1 reference

Tetraspanin CD151 promotes cell migration by regulating integrin trafficking

31 March 2020

1 reference

The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.

31 March 2020

1 reference

Functional domains in tetraspanin proteins

31 March 2020

1 reference

Complete predicted three-dimensional structure of the facilitator transmembrane protein and hepatitis C virus receptor CD81: conserved and variable structural domains in the tetraspanin superfamily

31 March 2020

1 reference

Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling

31 March 2020

1 reference

Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation

31 March 2020

1 reference

DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151

31 March 2020

1 reference

Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway

31 March 2020

1 reference

Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores.

31 March 2020

1 reference

Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes.

31 March 2020

1 reference

Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS.

31 March 2020

1 reference

The tetraspanin CD9 modulates epidermal growth factor receptor signaling in cancer cells

31 March 2020

1 reference

Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases

31 March 2020

1 reference

Dynamic regulation of a GPCR-tetraspanin-G protein complex on intact cells: central role of CD81 in facilitating GPR56-Galpha q/11 association

31 March 2020

1 reference

Membrane microdomains and proteomics: lessons from tetraspanin microdomains and comparison with lipid rafts

31 March 2020

1 reference

EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily

31 March 2020

1 reference

The tetraspanin D6.1A and its molecular partners on rat carcinoma cells.

31 March 2020

1 reference

Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins

31 March 2020

1 reference

Evaluation of prototype transmembrane 4 superfamily protein complexes and their relation to lipid rafts

31 March 2020

1 reference

Evidence for specific tetraspanin homodimers: inhibition of palmitoylation makes cysteine residues available for cross-linking

31 March 2020

1 reference

The palmitoylation of metastasis suppressor KAI1/CD82 is important for its motility- and invasiveness-inhibitory activity

31 March 2020

1 reference

A physical and functional link between cholesterol and tetraspanins

31 March 2020

1 reference

Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside).

31 March 2020

1 reference

Gangliosides play an important role in the organization of CD82-enriched microdomains

31 March 2020

1 reference

Exosome function: from tumor immunology to pathogen biology

31 March 2020

1 reference

T cell exosomes induce cholesterol accumulation in human monocytes via phosphatidylserine receptor

31 March 2020

1 reference

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

31 March 2020

1 reference

Tumor-derived exosomes: a new source of tumor rejection antigens

31 March 2020

1 reference

The ESCRT complexes: structure and mechanism of a membrane-trafficking network

31 March 2020

1 reference

Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes

31 March 2020

1 reference

The on-off story of protein palmitoylation

31 March 2020

1 reference

Palmitoylation: policing protein stability and traffic

31 March 2020

1 reference

Transmembrane asymmetry and lateral domains in biological membranes

31 March 2020

1 reference

The tetraspanin web modulates immune-signalling complexes

31 March 2020

1 reference

A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5

31 March 2020

1 reference

EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins

31 March 2020

1 reference

Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins

31 March 2020

1 reference

Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution

31 March 2020

1 reference

The gamete fusion process is defective in eggs of Cd9-deficient mice

31 March 2020

1 reference

The molecular players of sperm-egg fusion in mammals

31 March 2020

1 reference

Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis

31 March 2020

1 reference

Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro

31 March 2020

1 reference

Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion

31 March 2020

1 reference

Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism

31 March 2020

1 reference

Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor

31 March 2020

1 reference

MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells

31 March 2020

1 reference

Regulation of urokinase receptor proteolytic function by the tetraspanin CD82.

31 March 2020

1 reference

CD151 dynamics in carcinoma-stroma interaction: integrin expression, adhesion strength and proteolytic activity

31 March 2020

1 reference

31 March 2020

Mechanisms of metastasis

1 reference

Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression

31 March 2020

1 reference

Metastasis signatures: genes regulating tumor-microenvironment interactions predict metastatic behavior

31 March 2020

1 reference

Metastasis suppressors alter the signal transduction of cancer cells

31 March 2020

1 reference

Metastasis suppressors genes in cancer.

31 March 2020

1 reference

Structure of the Tetraspanin Main Extracellular Domain

31 March 2020

1 reference

KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2

31 March 2020

1 reference

Correlations between reduced expression of the metastasis suppressor gene KAI-1 and accumulation of p53 in uterine carcinomas and sarcomas.

31 March 2020

1 reference

Down-regulation of the metastasis suppressor protein KAI1/CD82 correlates with occurrence of metastasis, prognosis and presence of HPV DNA in human penile squamous cell carcinoma.

31 March 2020

1 reference

Adenoviral transduction of MRP-1/CD9 and KAI1/CD82 inhibits lymph node metastasis in orthotopic lung cancer model

31 March 2020

1 reference

Correlation between reduction of metastasis in the MDA-MB-435 model system and increased expression of the Kai-1 protein

31 March 2020

1 reference

Transduction of KAI1/CD82 cDNA promotes hematogenous spread of human lung-cancer cells in natural killer cell-depleted SCID mice

31 March 2020

1 reference

Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1

31 March 2020

1 reference

Regulation of c-Met signaling by the tetraspanin KAI-1/CD82 affects cancer cell migration

31 March 2020

1 reference

Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and ganglioside

31 March 2020

1 reference

KAI1 COOH-terminal interacting tetraspanin (KITENIN), a member of the tetraspanin family, interacts with KAI1, a tumor metastasis suppressor, and enhances metastasis of cancer

31 March 2020

1 reference

Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression

31 March 2020

1 reference

Down-regulation of KAI1 messenger RNA expression is not associated with loss of heterozygosity of the KAI1 gene region in lung adenocarcinoma.

31 March 2020

1 reference

Frequent Down-Regulation and Lack of Mutation of the KAI1 Metastasis Suppressor Gene in Epithelial Ovarian Carcinoma

31 March 2020

1 reference

Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines

31 March 2020

1 reference

Promoter hypermethylation of tetraspanin members contributes to their silencing in myeloma cell lines

31 March 2020

1 reference

KAI1 promoter activity is dependent on p53, junB and AP2: evidence for a possible mechanism underlying loss of KAI1 expression in cancer cells

31 March 2020

1 reference

Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET.

31 March 2020

1 reference

Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes

31 March 2020

1 reference

The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation

31 March 2020

1 reference

Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization

31 March 2020

1 reference

Down-regulation of CD9 in human ovarian carcinoma cell might contribute to peritoneal dissemination: morphologic alteration and reduced expression of beta1 integrin subsets

31 March 2020

1 reference

A specific microdomain ("glycosynapse 3") controls phenotypic conversion and reversion of bladder cancer cells through GM3-mediated interaction of alpha3beta1 integrin with CD9.

31 March 2020

1 reference

MRP-1/CD9 gene transduction downregulates Wnt signal pathways

31 March 2020

1 reference

Wnt signaling promotes oncogenic transformation by inhibiting c-Myc-induced apoptosis

31 March 2020

1 reference

The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling

31 March 2020

1 reference

Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma

31 March 2020

1 reference

MRP-1/CD9 gene transduction regulates the actin cytoskeleton through the downregulation of WAVE2

31 March 2020

1 reference

The WASP-WAVE protein network: connecting the membrane to the cytoskeleton

31 March 2020

1 reference

The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation

31 March 2020

1 reference

Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

31 March 2020

1 reference

Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization

31 March 2020

1 reference

Absence of CD9 enhances adhesion-dependent morphologic differentiation, survival, and matrix metalloproteinase-2 production in small cell lung cancer cells

31 March 2020

1 reference

Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells.

31 March 2020

1 reference

Regulatory role of tetraspanin CD9 in tumor-endothelial cell interaction during transendothelial invasion of melanoma cells

31 March 2020

2 references

31 March 2020

12 December 2020

Endothelial cell-driven regulation of CD9 or motility-related protein-1 expression in multiple myeloma cells within the murine 5T33MM model and myeloma patients.

1 reference

Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis.

31 March 2020

1 reference

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.

31 March 2020

1 reference

Tetraspanin CD81-regulated cell motility plays a critical role in intrahepatic metastasis of hepatocellular carcinoma

31 March 2020

1 reference

GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment

31 March 2020

1 reference

Pericellular activation of proMMP-7 (promatrilysin-1) through interaction with CD151.

31 March 2020

1 reference

Homophilic interactions of Tetraspanin CD151 up-regulate motility and matrix metalloproteinase-9 expression of human melanoma cells through adhesion-dependent c-Jun activation signaling pathways

31 March 2020

1 reference

CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin.

31 March 2020

1 reference

Characterization of mice lacking the tetraspanin superfamily member CD151

31 March 2020

1 reference

Kidney failure in mice lacking the tetraspanin CD151.

31 March 2020

1 reference

Colon carcinoma-associated glycoproteins recognized by monoclonal antibodies CO-029 and GA22-2

31 March 2020

1 reference

Possible involvement of tetraspanin CO‐029 in hematogenous intrahepatic metastasis of liver cancer cells

31 March 2020

1 reference

Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy

31 March 2020

1 reference

The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation

31 March 2020

1 reference

Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility

31 March 2020

1 reference

Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network

31 March 2020

1 reference

Integrin trafficking and the control of cell migration

31 March 2020

1 reference

A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression

31 March 2020

1 reference

The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7

31 March 2020

1 reference

The prothrombotic state in cancer: pathogenic mechanisms

31 March 2020

1 reference

Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029

31 March 2020

1 reference

Exosomes: a common pathway for a specialized function

31 March 2020

1 reference

Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer

31 March 2020

1 reference

The structural and mechanistic basis for recycling of Rab proteins between membrane compartments.

31 March 2020

1 reference

Powering membrane traffic in endocytosis and recycling

31 March 2020

1 reference

Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle

31 March 2020

1 reference

Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63

31 March 2020

1 reference

p130Cas: a versatile scaffold in signaling networks

31 March 2020

1 reference

TM4SF3 promotes esophageal carcinoma metastasis via upregulating ADAM12m expression

31 March 2020

1 reference

Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis

31 March 2020

1 reference

12 December 2020

Expression of a splice variant of KAI1, a tumor metastasis suppressor gene, influences tumor invasion and progression

1 reference

12 December 2020

Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-beta, and TGF-alpha is specifically triggered by different stimuli and involves different PKC isoenzymes

1 reference

12 December 2020

The tetraspanin superfamily: molecular facilitators

1 reference

12 December 2020

Complexes of tetraspanins with integrins: more than meets the eye

1 reference

12 December 2020

Epigenetic transfer of metastatic activity by uptake of highly metastatic B16 melanoma cell-released exosomes.

1 reference

12 December 2020

EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells.

1 reference

12 December 2020

Developmentally regulated expression of metastasis-associated antigens in the rat.

1 reference

12 December 2020

Protein-protein interactions in the tetraspanin web.

1 reference

12 December 2020

Gene expression profile of metastatic colon cancer cells resistant to cisplatin-induced apoptosis.

1 reference

12 December 2020

Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3

1 reference

12 December 2020

Progression of cervical carcinomas is associated with down-regulation of CD9 but strong local re-expression at sites of transendothelial invasion.

1 reference

12 December 2020

Genetic factors and suppression of metastatic ability of prostatic cancer

1 reference

12 December 2020

Trafficking and function of the tetraspanin CD63.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC2543

1 reference

19 August 2017

1 reference

PubMed ID

19078974