(Q37378223)

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Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes

scientific article published on February 15, 1998

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20 August 2017

Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes (English)

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20 August 2017

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uridine 5'-diphosphate

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9466980

6 December 2024

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L. Iyer

1

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6 December 2024

C. D. King

2

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6 December 2024

P. F. Whitington

3

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6 December 2024

M. D. Green

4

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6 December 2024

S. K. Roy

5

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6 December 2024

T. R. Tephly

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6 December 2024

B. L. Coffman

7

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6 December 2024

M. J. Ratain

8

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6 December 2024

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1 February 1998

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20 August 2017

15 February 1998

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=9466980

6 December 2024

full work available at URL

http://www.jci.org/articles/view/915/files/pdf

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6 December 2024

https://europepmc.org/articles/PMC508633

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Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9466980

6 December 2024

https://europepmc.org/articles/PMC508633?pdf=render

online access status

content deliverer

Europe PubMed Central

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A9466980

6 December 2024

http://www.jci.org/articles/view/915/files/pdf

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https://api.crossref.org/works/10.1172/JCI915

6 December 2024

Journal of Clinical Investigation

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20 August 2017

101

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Europe PubMed Central

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20 August 2017

4

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Europe PubMed Central

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20 August 2017

847-854

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

Human UGT2B7 catalyzes morphine glucuronidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase 1.1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Therapeutic activity of CPT-11, a DNA-topoisomerase I inhibitor, against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Identification and properties of a major plasma metabolite of irinotecan (CPT-11) isolated from the plasma of patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Mechanisms of inherited deficiencies of multiple UDP‐glucuronosyltransferase isoforms in two patients with Crigler‐Najjar syndrome, type I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Alteration of drug metabolism in Gilbert's syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

6 September 2017

Endogenous substrates for UDP-glucuronosyltransferases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

14 September 2017

Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

14 September 2017

Comparison of stably expressed rat UGT1.1 and UGT2B1 in the glucuronidation of opioid compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

28 September 2017

Gunn rat: a model for inherited deficiency of bilirubin glucuronidation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

28 September 2017

Expressed human UGT1.4 protein catalyzes the formation of quaternary ammonium-linked glucuronides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

28 September 2017

Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

28 September 2017

Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhi

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

26 June 2018

The chemical modification of human liver UDP-glucuronosyltransferase UGT1*6 reveals the involvement of a carboxyl group in catalysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

26 June 2018

Developmental alteration of hepatic UDP-glucuronosyltransferase and sulphotransferase towards androsterone and 4-nitrophenol in Wistar rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

26 June 2018

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

26 June 2018

Calcium phosphate-mediated gene transfer: a highly efficient transfection system for stably transforming cells with plasmid DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

26 June 2018

Glucuronidation of 3'-azido-3'-deoxythymidine in human liver microsomes: enzyme inhibition by drugs and steroid hormones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

26 June 2018

Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

2 September 2018

Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

2 September 2018

Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=508633

2 September 2018

Study on the mechanisms of diarrhea induced by a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats

1 reference

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2 September 2018

Pathogenesis of Gilbert's syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective inhibitory effect of organophosphates on UDP-glucuronyl transferase activities in rat liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenobarbital inducible UDP-glucuronosyltransferase is responsible for glucuronidation of 3′-azido-3′-deoxythymidine: Characterization of the enzyme in human and rat liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of glucuronidation of SN-38, the active metabolite of irinotecan, by valproic acid and phenobarbital

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UGT1*1 genotyping in a Canadian Inuit population

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Congenital familial nonhemolytic jaundice with kernicterus

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro glucuronidation of 3'-azido-3'-deoxythymidine by human liver. Role of UDP-glucuronosyltransferase 2 form

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Radioassay of UDP-glucuronosyltransferase activities toward endogenous substrates using labeled UDP-glucuronic acid and an organic solvent extraction procedure

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human liver oxidative metabolism of O6-benzylguanine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9466980

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

20 August 2017

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