(Q37389046)

20 August 2017

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title

Protein promiscuity and its implications for biotechnology (English)

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20 August 2017

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3

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20 August 2017

Irene Nobeli

1

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author name string

Angelo D Favia

series ordinal

2

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20 August 2017

1 February 2009

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20 August 2017

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20 August 2017

27

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20 August 2017

157-167

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20 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nbt1519

20 August 2017

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Sub-cellular localization and post-translational modifications of the Plasmodium yoelii enolase suggest moonlighting functions

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Exploiting temperature-dependent substrate promiscuity for nucleoside analogue activation by thymidine kinase from Thermotoga maritima

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Protein engineering: opportunities and challenges

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Enzyme recruitment in evolution of new function

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12 December 2020

Enzymes with extra talents: moonlighting functions and catalytic promiscuity

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12 December 2020

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Specificity in molecular design: a physical framework for probing the determinants of binding specificity and promiscuity in a biological environment.

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12 December 2020

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12 December 2020

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12 December 2020

A novel plant cysteine protease has a dual function as a regulator of 1-aminocyclopropane-1-carboxylic Acid synthase gene expression

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12 December 2020

Creation of a tailored aldolase for the parallel synthesis of sialic acid mimetics

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12 December 2020

Can we rationally design promiscuous drugs?

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12 December 2020

Calmodulin's flexibility allows for promiscuity in its interactions with target proteins and peptides

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12 December 2020

Molecular docking for substrate identification: the short-chain dehydrogenases/reductases.

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Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes

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Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies

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12 December 2020

High throughput screening assay for UDP-glucuronosyltransferase 1A1 glucuronidation profiling

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12 December 2020

Antibody multispecificity mediated by conformational diversity

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12 December 2020

Predicting undesirable drug interactions with promiscuous proteins in silico

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12 December 2020

Multidrug efflux pumps and resistance: regulation and evolution

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12 December 2020

One pathway, many products

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12 December 2020

Thermodynamic basis for promiscuity and selectivity in protein-protein interactions: PDZ domains, a case study

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12 December 2020

Functional promiscuity correlates with conformational heterogeneity in A-class glutathione S-transferases

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12 December 2020

Implications of protein flexibility for drug discovery

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12 December 2020

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12 December 2020

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

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12 December 2020

Structural analysis of affinity matured antibodies and laboratory-evolved enzymes

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12 December 2020

Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases

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12 December 2020

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12 December 2020

G protein selectivity is regulated by multiple intracellular regions of GPCRs

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12 December 2020

Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition

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Differential epitope positioning within the germline antibody paratope enhances promiscuity in the primary immune response

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12 December 2020

Promiscuous subunit interactions: a possible mechanism for the regulation of protein kinase CK2

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Modeling promiscuity based on in vitro safety pharmacology profiling data

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12 December 2020

Ligand specificity of nuclear hormone receptors: sifting through promiscuity

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12 December 2020

Moonlighting proteins.

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12 December 2020

Transition towards antigen-binding promiscuity of a monospecific antibody

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12 December 2020

Directed evolution of a (beta alpha)8-barrel enzyme to catalyze related reactions in two different metabolic pathways

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12 December 2020

CORRELATION OF STRUCTURE AND FUNCTION IN ENZYME ACTION

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12 December 2020

Crystal structure of the GpIbalpha-thrombin complex essential for platelet aggregation

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12 December 2020

Enthalpy–entropy compensation in the transition of a monospecific antibody towards antigen-binding promiscuity

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12 December 2020

The small heat-shock protein αB-crystallin as candidate autoantigen in multiple sclerosis

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12 December 2020

Practical limits of function prediction

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12 December 2020

Multiple paths to multispecificity

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12 December 2020

Novel enzyme activities and functional plasticity revealed by recombining highly homologous enzymes

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12 December 2020

Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein

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12 December 2020

Moonlighting proteins in yeasts

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12 December 2020

Pyruvate kinase type M2 and its role in tumor growth and spreading

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12 December 2020

Crystallographic and thermodynamic comparison of structurally diverse molecules binding to streptavidin

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12 December 2020

Small heat shock proteins, the cytoskeleton, and inclusion body formation

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12 December 2020

Ligand selectivity and competition between enzymes in silico.

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12 December 2020

Counting the zinc-proteins encoded in the human genome

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12 December 2020

Structural basis for ligand promiscuity in cytochrome P450 3A4.

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12 December 2020

Antibody evolution constrains conformational heterogeneity by tailoring protein dynamics

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12 December 2020

Synthetic biology: new engineering rules for an emerging discipline

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12 December 2020

Anatomy of the antibody molecule

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12 December 2020

Conformational analysis of drug-like molecules bound to proteins: an extensive study of ligand reorganization upon binding.

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12 December 2020

Detection of Epstein-Barr virus BGLF4 protein kinase in virus replication compartments and virus particles.

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12 December 2020

The monomer of pyruvate kinase, subtype M1, is both a kinase and a cytosolic thyroid hormone binding protein

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12 December 2020

Rapid evaluation of synthetic and molecular complexity for in silico chemistry

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12 December 2020

Diversity and regulation in the NF-kappaB system

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12 December 2020

Divergent evolution in the enolase superfamily: the interplay of mechanism and specificity

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12 December 2020

Catalytic promiscuity and the evolution of new enzymatic activities

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12 December 2020

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

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12 December 2020

New uses for old drugs

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12 December 2020

The catalytic versatility of erythrocyte carbonic anhydrase. VII. Kinetic studies of esterase activity and competitive inhibition by substrate analogs.

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12 December 2020

Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)

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12 December 2020

Single-gene disorders: what role could moonlighting enzymes play?

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12 December 2020

On the levels of enzymatic substrate specificity: implications for the early evolution of metabolic pathways

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12 December 2020

Protein stability promotes evolvability

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12 December 2020

Complementarity of Structure Ensembles in Protein-Protein Binding

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12 December 2020

Combinatorial and computational challenges for biocatalyst design

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12 December 2020

Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide

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12 December 2020

The generation of new protein functions by the combination of domains

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12 December 2020

Enzyme promiscuity: evolutionary and mechanistic aspects.

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12 December 2020

The 'evolvability' of promiscuous protein functions

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12 December 2020

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

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12 December 2020

Protein engineering 20 years on.

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12 December 2020

Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations

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12 December 2020

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

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12 December 2020

Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution

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12 December 2020

Evolution of function in protein superfamilies, from a structural perspective.

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12 December 2020

In silico methods for early toxicity assessment.

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12 December 2020

Enzyme promiscuity: mechanism and applications.

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12 December 2020

Structural and catalytic diversity within the amidohydrolase superfamily

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12 December 2020

Elucidating the mechanisms of cooperative calcium-calmodulin interactions: a structural systems biology approach.

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12 December 2020

Why metabolic enzymes are essential or nonessential for growth of Escherichia coli K12 on glucose.

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12 December 2020

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12 December 2020

Multifunctional proteins

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12 December 2020

Catalytic promiscuity in biocatalysis: using old enzymes to form new bonds and follow new pathways.

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12 December 2020

Directed enzyme evolution

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12 December 2020

Conformational proofreading: the impact of conformational changes on the specificity of molecular recognition

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12 December 2020

Conformational diversity and protein evolution--a 60-year-old hypothesis revisited

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12 December 2020

A ligand-centric analysis of the diversity and evolution of protein-ligand relationships in E.coli.

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12 December 2020

From magic bullets to designed multiple ligands

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12 December 2020

Short-chain dehydrogenases/reductases (SDR): the 2002 update

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12 December 2020

Underground metabolism

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12 December 2020

Drug target identification using side-effect similarity

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12 December 2020

Evolutionary plasticity of protein families: coupling between sequence and structure variation

1 reference

12 December 2020

Promiscuity: what protects us, perplexes us.

1 reference

12 December 2020

When fold is not important: a common structural framework for adenine and AMP binding in 12 unrelated protein families

1 reference

12 December 2020

Do current sequence analysis algorithms disclose multifunctional (moonlighting) proteins?

1 reference

12 December 2020

Specificity and Promiscuity in Protein–Ligand and Protein–Protein Interactions

1 reference

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NBT1519

1 reference

20 August 2017

1 reference

PubMed ID

19204698