(Q37466253)

20 August 2017

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title

Programmed cell death pathways and current antitumor targets (English)

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20 August 2017

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Mei Lan Tan

1

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20 August 2017

Jer Ping Ooi

2

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20 August 2017

Nawfal Ismail

3

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20 August 2017

Ahmed Ismail Hassan Moad

4

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20 August 2017

Tengku Sifzizul Tengku Muhammad

5

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20 August 2017

30 April 2009

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20 August 2017

Pharmaceutical Research

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20 August 2017

26

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20 August 2017

1547-1560

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20 August 2017

7

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

20 August 2017

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https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Bcl-2 family members: dual regulators of apoptosis and autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Bortezomib, paclitaxel, and carboplatin as a first-line regimen for patients with metastatic esophageal, gastric, and gastroesophageal cancer: phase II results from the North Central Cancer Treatment Group (N044B).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Autophagic cell death unraveled: Pharmacological inhibition of apoptosis and autophagy enables necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Differentiation-dependent autophagy controls the fate of newly synthesized N-linked glycoproteins in the colon adenocarcinoma HT-29 cell line.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Role of autophagy in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Molecular mechanisms of Polygonatum cyrtonema lectin-induced apoptosis and autophagy in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Switch between apoptosis and autophagy: radiation-induced endoplasmic reticulum stress?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-009-9895-1

Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial.

21 January 2018

1 reference

12 December 2020

Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins

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12 December 2020

Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome

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12 December 2020

Temsirolimus, an mTOR inhibitor for treatment of patients with advanced renal cell carcinoma

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12 December 2020

Cellular autophagic capacity changes during azaserine-induced tumour progression in the rat pancreas. Up-regulation in all premalignant stages and down-regulation with loss of cycloheximide sensitivity of segregation along with malignant transformat

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12 December 2020

Cell death: the significance of apoptosis

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12 December 2020

The mammalian target of rapamycin kinase and tumor growth inhibition

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12 December 2020

Tor signalling in bugs, brain and brawn

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12 December 2020

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

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12 December 2020

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

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12 December 2020

Autophagy, amyloidogenesis and Alzheimer disease

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12 December 2020

Regulation of protein degradation in normal and transformed human bronchial epithelial cells in culture

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12 December 2020

Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs

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12 December 2020

Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma

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12 December 2020

Phase 1 and Pharmacokinetic Study of Lexatumumab in Patients with Advanced Cancers

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12 December 2020

In vitro evaluation of the anticancer effect of lactoferrin and tea polyphenol combination on oral carcinoma cells

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12 December 2020

Autophagy: from phenomenology to molecular understanding in less than a decade

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12 December 2020

Huntington's disease: the mystery unfolds?

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12 December 2020

Apoptosis. Its significance in cancer and cancer therapy

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12 December 2020

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

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12 December 2020

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

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12 December 2020

Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia

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12 December 2020

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

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12 December 2020

Smac/DIABLO is required for effector caspase activation during apoptosis in human cells

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12 December 2020

BH3 mimetics to improve cancer therapy; mechanisms and examples

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12 December 2020

Temozolomide for High Grade Glioma

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12 December 2020

Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts.

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12 December 2020

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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12 December 2020

Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignancies

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12 December 2020

Bcl-2-targeted antisense therapy (Oblimersen sodium): towards clinical reality

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12 December 2020

The molecular mechanism of autophagy

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12 December 2020

A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies

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12 December 2020

DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells

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12 December 2020

Regulation and role of autophagy in mammalian cells

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12 December 2020

Autophagic and apoptotic response to stress signals in mammalian cells

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12 December 2020

Autophagy: highlighting a novel player in the autoimmunity scenario

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12 December 2020

Tissue protein turnover during liver carcinogenesis

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12 December 2020

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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12 December 2020

Changes in cellular autophagic capacity during azaserine-initiated pancreatic carcinogenesis

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12 December 2020

The HIV protease inhibitor saquinavir induces endoplasmic reticulum stress, autophagy, and apoptosis in ovarian cancer cells

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12 December 2020

The Hallmarks of Cancer

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12 December 2020

Mechanisms of mitochondrial outer membrane permeabilization.

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12 December 2020

Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells.

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12 December 2020

Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae

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12 December 2020

Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells

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12 December 2020

Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53.

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12 December 2020

Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation.

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12 December 2020

Cell death: critical control points

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12 December 2020

Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies

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12 December 2020

Dueling activities of AIF in cell death versus survival: DNA binding and redox activity

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12 December 2020

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

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12 December 2020

Feasibility of administering oblimersen (G3139; Genasense) with imatinib mesylate in patients with imatinib resistant chronic myeloid leukemia--Cancer and leukemia group B study 10107.

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12 December 2020

Apoptosis in the pathogenesis and treatment of disease

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12 December 2020

TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.

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12 December 2020

Autophagy and tumor suppression: recent advances in understanding the link between autophagic cell death pathways and tumor development

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12 December 2020

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

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12 December 2020

Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer

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12 December 2020

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

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12 December 2020

Gossypol treatment of recurrent adult malignant gliomas

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12 December 2020

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

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12 December 2020

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

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12 December 2020

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

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12 December 2020

A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies

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12 December 2020

Discovery, regulation, and action of the major apoptotic nucleases DFF40/CAD and endonuclease G.

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12 December 2020

Autophagy as a cell death and tumor suppressor mechanism

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12 December 2020

Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats

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12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

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12 December 2020

Phase I-II trial of bortezomib plus oral cyclophosphamide and prednisone in relapsed and refractory multiple myeloma

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12 December 2020

Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas

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12 December 2020

Autophagy regulates the processing of amino terminal huntingtin fragments

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12 December 2020

Apoptosis, cancer and cancer therapy.

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12 December 2020

Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy

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12 December 2020

Advances in apoptosis research

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12 December 2020

A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies.

1 reference

12 December 2020

Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

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12 December 2020

Bortezomib and gemcitabine in relapsed or refractory Hodgkin's lymphoma.

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12 December 2020

The proteasome and the delicate balance between destruction and rescue

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12 December 2020

Hypoxia--a key regulatory factor in tumour growth

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12 December 2020

IAP proteins: blocking the road to death's door

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12 December 2020

Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling

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12 December 2020

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

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12 December 2020

Apoptosis genes and autoimmunity.

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12 December 2020

The biochemistry of apoptosis

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12 December 2020

Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

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12 December 2020

Apoptosis-targeted therapies for cancer

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12 December 2020

The role of autophagy in cancer development and response to therapy.

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12 December 2020

Cell death in health and disease: the biology and regulation of apoptosis

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12 December 2020

Phase I study of obatoclax mesylate (GX15-070), a small molecule pan-Bcl-2 family antagonist, in patients with advanced chronic lymphocytic leukemia

1 reference

12 December 2020

An informatics approach identifying markers of chemosensitivity in human cancer cell lines.

1 reference

12 December 2020

The role of autophagy during the early neonatal starvation period

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12 December 2020

Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells

1 reference

12 December 2020

Safety and antitumor activity of recombinant soluble Apo2 ligand

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12 December 2020

The role of Bcl-2 family members in tumorigenesis

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12 December 2020

Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group

1 reference

12 December 2020

Kinetics of cellular proliferation and cell loss in human carcinomas. A discussion of methods available for in vivo studies

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12 December 2020

Treatment resistance of solid tumors: role of hypoxia and anemia

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12 December 2020

Autophagy: a barrier or an adaptive response to cancer.

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12 December 2020

Growth arrest and non-apoptotic programmed cell death associated with the up-regulation of c-myc mRNA expression in T-47D breast tumor cells following exposure to Epipremnum pinnatum (L.) Engl. hexane extract.

1 reference

12 December 2020

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

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12 December 2020

Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

1 reference

12 December 2020

Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study

1 reference

12 December 2020

Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution

1 reference

12 December 2020

Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy

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12 December 2020

Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria?

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12 December 2020

Endocytosis and autophagy in dying neurons: an ultrastructural study in chick embryos

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12 December 2020

Apoptosis signaling by death receptors.

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12 December 2020

Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.

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12 December 2020

Deforolimus (AP23573) a novel mTOR inhibitor in clinical development

1 reference

12 December 2020

Stress-resistance conferred by high level of bcl-2 alpha protein in human B lymphoblastoid cell.

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12 December 2020

Cell loss as a factor in the growth rate of human tumours

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12 December 2020

Continuous administration of daily low-dose temozolomide in pretreated patients with advanced non-small cell lung cancer: a phase II study

1 reference

12 December 2020

A preliminary clinical study of gossypol in advanced human cancer

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12 December 2020

Molecular regulation of vessel maturation

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12 December 2020

Consolidation therapy with bortezomib/lenalidomide/ dexamethasone versus bortezomib/dexamethasone after a dexamethasone-based induction regimen in patients with multiple myeloma: a randomized phase III trial

1 reference

12 December 2020

Endonuclease G is required for early embryogenesis and normal apoptosis in mice

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12 December 2020

Differential modulation of apoptosis sensitivity in CD95 type I and type II cells.

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12 December 2020

PROGRAMMED CELL DEATH--I. CYTOLOGY OF DEGENERATION IN THE INTERSEGMENTAL MUSCLES OF THE PERNYI SILKMOTH.

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12 December 2020

Autophagy in health and disease: a double-edged sword

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12 December 2020

Smac/DIABLO enhances the therapeutic potential of chemotherapeutic drugs and irradiation, and sensitizes TRAIL-resistant breast cancer cells

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12 December 2020

The TRAIL apoptotic pathway in cancer onset, progression and therapy

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12 December 2020

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12 December 2020

Bcl-2 family proteins and cancer

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12 December 2020

Role of Smac/DIABLO in cancer progression

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12 December 2020

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

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12 December 2020

Induction of autophagy and inhibition of tumorigenesis by beclin 1

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12 December 2020

Programmed cell death and apoptosis: origins of the theory.

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12 December 2020

Expanded CAG repeats in exon 1 of the Huntington's disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

1 reference

12 December 2020

Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma

1 reference

12 December 2020

Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation

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12 December 2020

A matter of life and death

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12 December 2020

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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12 December 2020

Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors.

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12 December 2020

The Bcl-2 apoptotic switch in cancer development and therapy

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12 December 2020

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

1 reference

12 December 2020

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

1 reference

12 December 2020

X-linked IAP is a direct inhibitor of cell-death proteases

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12 December 2020

Phase I study of bortezomib with weekly paclitaxel in patients with advanced solid tumours.

1 reference

12 December 2020

Apoptosis in the nervous system

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12 December 2020

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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12 December 2020

BCL-2 family members and the mitochondria in apoptosis

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12 December 2020

Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging

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12 December 2020

Mitochondrial Endonuclease G function in apoptosis and mtDNA metabolism: a historical perspective

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12 December 2020

Autophagy: in sickness and in health

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12 December 2020

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12 December 2020

Cancer genes and the pathways they control

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12 December 2020

Autophagy in the eukaryotic cell

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12 December 2020

Utility of bortezomib retreatment in relapsed or refractory multiple myeloma patients: a multicenter case series.

1 reference

12 December 2020

The Bcl-2 protein family

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12 December 2020

Development by self-digestion: molecular mechanisms and biological functions of autophagy

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12 December 2020

mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

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12 December 2020

Randomized phase II Study of carboplatin and etoposide with or without the bcl-2 antisense oligonucleotide oblimersen for extensive-stage small-cell lung cancer: CALGB 30103.

1 reference

12 December 2020

10.1007/S11095-009-9895-1

Identifiers

DOI

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release_2rtq2ii6gjbzdbegngsbockqlq

20 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/2rtq2ii6gjbzdbegngsbockqlq

24 November 2022

mapped directly with Wikidata item

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