(Q37489930)

20 August 2017

1 reference

title

The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment (English)

1 reference

20 August 2017

Takuya Sato

1

1 reference

PubMed ID

19456272

20 August 2017

Noriko Gotoh

series ordinal

2

1 reference

PubMed ID

19456272

20 August 2017

language of work or name

English

0 references

publication date

1 June 2009

1 reference

Expert Opinion on Therapeutic Targets

20 August 2017

1 reference

20 August 2017

13

1 reference

20 August 2017

689-700

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20 August 2017

6

1 reference

Cell signaling by receptor tyrosine kinases

20 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Structural and functional diversity of adaptor proteins involved in tyrosine kinase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Trans-activation of EphA4 and FGF receptors mediated by direct interactions between their cytoplasmic domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

The RET proto-oncogene: a molecular therapeutic target in thyroid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Association of the signaling adaptor FRS2 with fibroblast growth factor receptor 1 (Fgfr1) is mediated by alternative splicing of the juxtamembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Cellular signaling by fibroblast growth factor receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

The role of Shp2 (PTPN11) in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Direct cell cycle regulation by the fibroblast growth factor receptor (FGFR) kinase through phosphorylation-dependent release of Cks1 from FGFR substrate 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Direct interaction of Rnd1 with FRS2 beta regulates Rnd1-induced down-regulation of RhoA activity and is involved in fibroblast growth factor-induced neurite outgrowth in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Tyrosine phosphorylation sites on FRS2alpha responsible for Shp2 recruitment are critical for induction of lens and retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

FRS2 alpha 2F/2F mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Essential role of Shp2-binding sites on FRS2alpha for corticogenesis and for FGF2-dependent proliferation of neural progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Role of epithelial cell fibroblast growth factor receptor substrate 2alpha in prostate development, regeneration and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Fibroblast growth factor signaling in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Aberrant fibroblast growth factor receptor signaling in bladder and other cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

IIIc isoform of fibroblast growth factor receptor 1 is overexpressed in human pancreatic cancer and enhances tumorigenicity of hamster ductal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Somatic mutations affect key pathways in lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Tumour suppressive properties of fibroblast growth factor receptor 2-IIIb in human bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Glioma stem cells: a midterm exam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Fibroblast growth factor receptor (FGFR) 4 correlated with the malignancy of human astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

A different view on DNA amplifications indicates frequent, highly complex, and stable amplicons on 12q13-21 in glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

RET tyrosine kinase signaling in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Sprouty and cancer: the first terms report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

The ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Aberrant expression of Cks1 and Cks2 contributes to prostate tumorigenesis by promoting proliferation and inhibiting programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Characterization of the 12q amplicons by high-resolution, oligonucleotide array CGH and expression analyses of a novel liposarcoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Feedback inhibitors of the epidermal growth factor receptor signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

ERBB receptors and cancer: the complexity of targeted inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Protein-protein interactions as targets for small-molecule therapeutics in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

The atomic structure of protein-protein recognition sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Principles of protein-protein interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Structure-based maximal affinity model predicts small-molecule druggability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

A hot spot of binding energy in a hormone-receptor interface

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Hot-spot mimicry of a cytokine receptor by a small molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Hot spots--a review of the protein-protein interface determinant amino-acid residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Targeted delivery of small interfering RNA: approaching effective cancer therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Antisense therapy for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast gro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

Inhibition of human papillomavirus DNA replication by small molecule antagonists of the E1-E2 protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220902942330

10.1517/14728220902942330

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19456272