(Q37582773)

21 August 2017

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title

Environment-mediated drug resistance: a major contributor to minimal residual disease (English)

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21 August 2017

Mark B Meads

1

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21 August 2017

Robert A Gatenby

series ordinal

2

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21 August 2017

William S Dalton

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

20 August 2009

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21 August 2017

Nature Reviews Cancer

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21 August 2017

9

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21 August 2017

665-674

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21 August 2017

9

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https://scigraph.springernature.com/pub.10.1038/nrc2714

21 August 2017

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cites work

The bone marrow microenvironment as a tumor sanctuary and contributor to drug resistance

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beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury.

31 March 2020

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Beta1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells.

31 March 2020

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Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines.

31 March 2020

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Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas

31 March 2020

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Disseminated tumor cells of breast cancer patients: a strong prognostic factor for distant and local relapse

31 March 2020

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A pooled analysis of bone marrow micrometastasis in breast cancer

31 March 2020

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Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients

31 March 2020

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Isolated tumor cells in bone marrow three years after diagnosis in disease-free breast cancer patients predict unfavorable clinical outcome

31 March 2020

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Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia

31 March 2020

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Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo.

31 March 2020

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MRD parameters using immunophenotypic detection methods are highly reliable in predicting survival in acute myeloid leukaemia

31 March 2020

1 reference

Gene expression profiling of minimal residual disease in acute myeloid leukaemia by novel multiplex-PCR-based method

31 March 2020

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Minimal residual disease in gastric cancer: evidence of an independent prognostic relevance of urokinase receptor expression by disseminated tumor cells in the bone marrow

31 March 2020

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Treatment of acute lymphoblastic leukemia

31 March 2020

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Combination therapy of an anticancer drug with the FNIII14 peptide of fibronectin effectively overcomes cell adhesion-mediated drug resistance of acute myelogenous leukemia

31 March 2020

1 reference

Very late antigen-4 function of myeloblasts correlates with improved overall survival for patients with acute myeloid leukemia

31 March 2020

1 reference

Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine.

31 March 2020

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Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas

31 March 2020

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Increased beta1 integrin is associated with decreased survival in invasive breast cancer

31 March 2020

1 reference

Expression of MAC-1 (CD11b) in acute myeloid leukemia (AML) is associated with an unfavorable prognosis

31 March 2020

1 reference

Increased gene expression levels of collagen receptor integrins are associated with decreased survival parameters in patients with advanced melanoma

31 March 2020

1 reference

Integrin chains beta1 and alphav as prognostic factors in human metastatic melanoma.

31 March 2020

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Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo

31 March 2020

1 reference

Remodeling of the extracellular matrix through overexpression of collagen VI contributes to cisplatin resistance in ovarian cancer cells.

31 March 2020

1 reference

Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis

31 March 2020

1 reference

Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia

31 March 2020

1 reference

Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2

31 March 2020

1 reference

Minimal residual disease in acute myeloid leukemia is predicted by an apoptosis-resistant protein profile at diagnosis.

31 March 2020

1 reference

A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia

31 March 2020

1 reference

Tumor stroma and regulation of cancer development

31 March 2020

1 reference

Stromal gene expression predicts clinical outcome in breast cancer

31 March 2020

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Breast carcinoma-associated fibroblasts and their counterparts display neoplastic-specific changes.

31 March 2020

1 reference

Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions

31 March 2020

1 reference

Co-evolution of tumor cells and their microenvironment

31 March 2020

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Stromal gene signatures in large-B-cell lymphomas

31 March 2020

1 reference

Reconstituted basement membrane (matrigel) and laminin can enhance the tumorigenicity and the drug resistance of small cell lung cancer cell lines

31 March 2020

1 reference

Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis

31 March 2020

1 reference

Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo

31 March 2020

1 reference

Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts

31 March 2020

1 reference

Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR).

31 March 2020

1 reference

Overexpression of integrin beta1 inhibits proliferation of hepatocellular carcinoma cell SMMC-7721 through preventing Skp2-dependent degradation of p27 via PI3K pathway.

31 March 2020

1 reference

CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.

31 March 2020

1 reference

ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase

31 March 2020

1 reference

Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms

31 March 2020

1 reference

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

31 March 2020

1 reference

Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer

31 March 2020

1 reference

Autocrine interleukin-6 production and highly malignant multiple myeloma: relation with resistance to drug-induced apoptosis

31 March 2020

1 reference

Bone marrow stroma confers resistance to Apo2 ligand/TRAIL in multiple myeloma in part by regulating c-FLIP.

31 March 2020

1 reference

Inhibition of interleukin-6 signaling with CNTO 328 enhances the activity of bortezomib in preclinical models of multiple myeloma.

31 March 2020

1 reference

Molecular characterization of the tumor microenvironment in breast cancer

31 March 2020

1 reference

Phenotypic and functional characterization of bone marrow mesenchymal stem cells derived from patients with multiple myeloma

31 March 2020

1 reference

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

31 March 2020

1 reference

Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1.

31 March 2020

1 reference

Integrins and cytokines activate nuclear transcription factor-kappaB in human neutrophils

31 March 2020

1 reference

Beta1 integrin adhesion enhances IL-6-mediated STAT3 signaling in myeloma cells: implications for microenvironment influence on tumor survival and proliferation

31 March 2020

1 reference

Altered expression of fibronectin and collagens I and IV in multiple myeloma and monoclonal gammopathy of undetermined significance

31 March 2020

1 reference

Addressing the role of cell adhesion in tumor cell dormancy

31 March 2020

1 reference

Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

31 March 2020

1 reference

Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells

31 March 2020

1 reference

Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction.

31 March 2020

1 reference

Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies

31 March 2020

1 reference

Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells

31 March 2020

1 reference

Disruption of fibronectin binding to the alpha 5 beta 1 integrin stimulates the expression of cyclin-dependent kinases and DNA synthesis through activation of extracellular signal-regulated kinase.

31 March 2020

1 reference

Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27.

31 March 2020

1 reference

Contact with fibrillar collagen inhibits melanoma cell proliferation by up-regulating p27KIP1

31 March 2020

1 reference

Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines

31 March 2020

1 reference

Paracrine interactions of basic fibroblast growth factor and interleukin-6 in multiple myeloma

31 March 2020

1 reference

Integrin inhibitors reaching the clinic

31 March 2020

1 reference

Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH(2)), a beta integrin antagonist, in patients with solid tumours

31 March 2020

1 reference

Phase I trial of a monoclonal antibody specific for alphavbeta3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion

31 March 2020

1 reference

Phase I evaluation of a fully human anti-alphav integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors.

31 March 2020

1 reference

Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme

31 March 2020

1 reference

A phase II clinical trial does not show that high dose simvastatin has beneficial effect on markers of bone turnover in multiple myeloma

31 March 2020

1 reference

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

31 March 2020

1 reference

Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo

31 March 2020

1 reference

Molecular mechanism of the anti-cancer activity of cerivastatin, an inhibitor of HMG-CoA reductase, on aggressive human breast cancer cells

31 March 2020

1 reference

The HMG-CoA reductase inhibitor simvastatin overcomes cell adhesion-mediated drug resistance in multiple myeloma by geranylgeranylation of Rho protein and activation of Rho kinase

31 March 2020

1 reference

Ras GTPases: integrins' friends or foes?

31 March 2020

1 reference

RhoA and Rac1 GTPases play major and differential roles in stromal cell-derived factor-1-induced cell adhesion and chemotaxis in multiple myeloma.

31 March 2020

1 reference

First clinical experience with simvastatin to overcome drug resistance in refractory multiple myeloma

31 March 2020

1 reference

Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation

31 March 2020

1 reference

Stimulation of bone formation in vitro and in rodents by statins

31 March 2020

1 reference

Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells

31 March 2020

1 reference

Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma

31 March 2020

1 reference

Bortezomib, dexamethasone, and fibroblast growth factor receptor 3-specific tyrosine kinase inhibitor in t(4;14) myeloma

31 March 2020

1 reference

Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.

31 March 2020

1 reference

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

31 March 2020

1 reference

Cell adhesion to fibronectin (CAM-DR) influences acquired mitoxantrone resistance in U937 cells.

31 March 2020

1 reference

Chemotherapeutic treatment of bone marrow stromal cells strongly affects their protective effect on acute myeloid leukemia cell survival.

31 March 2020

1 reference

Bystander elimination of antigen loss variants in established tumors

31 March 2020

1 reference

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

31 March 2020

1 reference

Equilibrium between host and cancer caused by effector T cells killing tumor stroma

31 March 2020

1 reference

A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma

31 March 2020

1 reference

Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma

31 March 2020

1 reference

12 December 2020

Status of minimal residual disease testing in childhood haematological malignancies

1 reference

12 December 2020

Quantitative model for multiple levels of drug resistance in clinical tumors.

1 reference

12 December 2020

The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment

1 reference

12 December 2020

Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy

1 reference

12 December 2020

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate

1 reference

12 December 2020

Development and characterization of a melphalan-resistant human multiple myeloma cell line

1 reference

12 December 2020

Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from nonmetastatic breast tumors as revealed by labeling with green fluorescent protein

1 reference

12 December 2020

Relationship between minimal residual disease and outcome in adult acute lymphoblastic leukemia.

1 reference

12 December 2020

Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell lines

1 reference

12 December 2020

Integrin activation suppresses etoposide-induced DNA strand breakage in cultured murine tumor-derived endothelial cells

1 reference

12 December 2020

Increased expression of integrin beta1 is a poor prognostic factor in small-cell lung cancer

1 reference

12 December 2020

Blocking signaling through the Gp130 receptor chain by interleukin-6 and oncostatin M inhibits PC-3 cell growth and sensitizes the tumor cells to etoposide and cisplatin-mediated cytotoxicity

1 reference

12 December 2020

Genotypic and phenotypic comparisons of de novo and acquired melphalan resistance in an isogenic multiple myeloma cell line model

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12 December 2020

Identifiers

DOI

10.1038/NRC2714

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21 August 2017

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