(Q37585050)

PubMed publication ID

21 August 2017

2 references

18 July 2021

Recent advances in the discovery of haem-targeting drugs for malaria and schistosomiasis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6254801&resulttype=core&format=json

13 May 2020

0 references

0 references

1 reference

18 July 2021

Katherine A de Villiers

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6254801&resulttype=core&format=json

13 May 2020

Timothy J Egan

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6254801&resulttype=core&format=json

13 May 2020

language of work or name

English

0 references

publication date

4 August 2009

2 references

PubMed publication ID

21 August 2017

18 July 2021

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6254801&resulttype=core&format=json

13 May 2020

18 July 2021

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6254801&resulttype=core&format=json

13 May 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6254801&resulttype=core&format=json

13 May 2020

page(s)

2868-2887

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6254801&resulttype=core&format=json

Creative Commons Attribution

13 May 2020

copyright license

1 reference

18 July 2021

0 references

Fate of haem iron in the malaria parasite Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Antimalarials increase vesicle pH in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Hemolysis of mouse erythrocytes by ferriprotoporphyrin IX and chloroquine. Chemotherapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

The chemical basis for the ferriprotoporphyrin IX-chloroquine complex induced lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

MALARIAL PIGMENT (SO-CALLED MELANIN): ITS NATURE AND MODE OF PRODUCTION

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Haemozoin in Schistosoma mansoni.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Haemozoin formation in the midgut of the blood-sucking insect Rhodnius prolixus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Structural and morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

The role of neutral lipid nanospheres in Plasmodium falciparum haem crystallization.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Haemozoin (beta-haematin) biomineralization occurs by self-assembly near the lipid/water interface

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Theories on malarial pigment formation and quinoline action

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Amodiaquine alone, amodiaquine+sulfadoxine-pyrimethamine, amodiaquine+artesunate, and artemether-lumefantrine for outpatient treatment of malaria in Tanzanian children: a four-arm randomised effectiveness trial

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Morphological Effects of Chloroquine on Plasmodium berghei in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Mode of Action of Chloroquine on Plasmodium berghei and P. cynomolgi

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Studies on the antimalarial mode of action of quinoline-containing drugs: time-dependence and irreversibility of drug action, and interactions with compounds that alter the function of the parasite's food vacuole

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

On the molecular mechanism of chloroquine's antimalarial action

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Characterisation of synthetic beta-haematin and effects of the antimalarial drugs quinidine, halofantrine, desbutylhalofantrine and mefloquine on its formation

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Chemotherapy of schistosomiasis: present and future

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

A benzodiazepine derivative and praziquantel: effects on musculature of Schistosoma mansoni and Schistosoma japonicum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Inhibition of heme aggregation by chloroquine reduces Schistosoma mansoni infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Schistosomicidal activity of the antimalarial drug, mefloquine, in Schistosoma mansoni-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Medical need, scientific opportunity and the drive for antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Should chloroquine be laid to rest?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Plasmodium: drug discovery and development--an industrial perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Targeting the hemozoin synthesis pathway for new antimalarial drug discovery: technologies for in vitro beta-hematin formation assay

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Colorimetric high-throughput screen for detection of heme crystallization inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

A comparison and analysis of several ways to promote haematin (haem) polymerisation and an assessment of its initiation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

A colorimetric high-throughput beta-hematin inhibition screening assay for use in the search for antimalarial compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Interactions of quinoline antimalarials with hematin in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

The interaction of the heme-octapeptide, N-acetylmicroperoxidase-8 with antimalarial drugs: solution studies and modeling by molecular mechanics methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

The crystal structure of halofantrine-ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Hemozoin: oil versus water

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Inhibition of heme crystal growth by antimalarials and other compounds: implications for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

The structure of malaria pigment beta-haematin

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Synthesis of combinatorial libraries based on terpenoid scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Synthesis, antimalarial activity, and molecular modeling of new pyrrolo[1,2-a]quinoxalines, bispyrrolo[1,2-a]quinoxalines, bispyrido[3,2-e]pyrrolo[1,2-a]pyrazines, and bispyrrolo[1,2-a]thieno[3,2-e]pyrazines

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Redox and antioxidant systems of the malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Xanthones as antimalarial agents: discovery, mode of action, and optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Evaluation and lead optimization of anti-malarial acridones

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Discovery of dual function acridones as a new antimalarial chemotype

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

A 3D QSAR pharmacophore model and quantum chemical structure--activity analysis of chloroquine(CQ)-resistance reversal

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES14082868

Current understanding of the molecular basis of chloroquine-resistance in Plasmodium falciparum.

21 January 2018

1 reference

12 December 2020

Cytochalasin D abolishes the schistosomicidal activity of praziquantel

1 reference

12 December 2020

Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells

1 reference

12 December 2020

Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols

1 reference

12 December 2020

Drug alert: halofantrine

1 reference

12 December 2020

Relationship between antimalarial drug activity, accumulation, and inhibition of heme polymerization in Plasmodium falciparum in vitro.

1 reference

12 December 2020

The quinine-haemin interaction and its relationship to antimalarial activity

1 reference

12 December 2020

Short report: floxacrine analog WR 243251 inhibits hematin polymerization

1 reference

12 December 2020

Heme polymerase activity and the stage specificity of antimalarial action of chloroquine.

1 reference

12 December 2020

10.3390/MOLECULES14082868

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6254801&resulttype=core&format=json

13 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6254801&resulttype=core&format=json

13 May 2020

PubMed publication ID

19701131

1 reference