(Q37684974)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

title

Targeting renal cell carcinoma with a HIF-2 antagonist (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

He Zhang

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Kevin H. Gardner

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

author name string

Wenfang Chen

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Haley Hill

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Alana Christie

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Min Soo Kim

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Eboni Holloman

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Andrea Pavia-Jimenez

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Farrah Homayoun

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Yuanqing Ma

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Nirav Patel

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Paul Yell

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Qurratulain Yousuf

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Allison Joyce

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Ivan Pedrosa

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Heather Geiger

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Jenny Chang

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Richard K Bruick

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Catherine Reeves

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Tae Hyun Hwang

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Kevin Courtney

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Eugene Frenkel

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Xiankai Sun

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Naseem Zojwalla

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Tai Wong

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

James P Rizzi

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Eli M Wallace

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

John A Josey

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Yang Xie

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Xian-Jin Xie

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Payal Kapur

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Renée M McKay

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

James Brugarolas

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

language of work or name

English

0 references

publication date

5 September 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

volume

539

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

page(s)

112-117

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

issue

7627

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nature19796

22 March 2020

exact match

0 references

cites work

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Structural integration in hypoxia-inducible factors

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

HTSeq--a Python framework to work with high-throughput sequencing data

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Establishing a human renal cell carcinoma tumorgraft platform for preclinical drug testing

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Molecular genetics of clear-cell renal cell carcinoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Simultaneous isolation of high-quality DNA, RNA, miRNA and proteins from tissues for genomic applications

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Development of Inhibitors of the PAS-B Domain of the HIF-2α Transcription Factor

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

STAR: ultrafast universal RNA-seq aligner

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

RSeQC: quality control of RNA-seq experiments

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

BAP1 loss defines a new class of renal cell carcinoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

A complex task? Direct modulation of transcription factors with small molecules

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Artificial ligand binding within the HIF2 PAS-B domain of the HIF2 transcription factor

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Accurate whole human genome sequencing using reversible terminator chemistry

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Mutations of the VHL tumour suppressor gene in renal carcinoma

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

MR classification of renal masses with pathologic correlation.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5340502

Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma.

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27595394

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE19796

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27595394%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference