(Q37714309)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20300106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

review article

1 reference

title

Targeting metabolic transformation for cancer therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20300106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20300106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Daniel A Tennant

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20300106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

Raúl Durán

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20300106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

author name string

Raúl V Durán

series ordinal

2

1 reference

22 August 2017

language of work or name

English

0 references

publication date

19 March 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20300106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20300106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20300106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

page(s)

267-277

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20300106%20AND%20SRC:MED&resulttype=core&format=json

21 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20300106%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrc2817

21 January 2020

exact match

0 references

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Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.

31 March 2020

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

31 March 2020

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Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site

31 March 2020

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Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

31 March 2020

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Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

31 March 2020

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TOR signaling in growth and metabolism

31 March 2020

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

31 March 2020

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Tumours with PI3K activation are resistant to dietary restriction

31 March 2020

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Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions

31 March 2020

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

31 March 2020

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PI3K and mTOR inhibitors: a new generation of targeted anticancer agents

31 March 2020

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New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

31 March 2020

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Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

31 March 2020

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Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

31 March 2020

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Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

31 March 2020

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Nucleoside analogs: molecular mechanisms signaling cell death.

31 March 2020

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The molecular determinants of de novo nucleotide biosynthesis in cancer cells

31 March 2020

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Application of metabolic-control logic to fuel utilization and its significance in tumor cells

31 March 2020

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Molecular imaging of cancer with positron emission tomography

31 March 2020

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2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

31 March 2020

1 reference

Effect of lonidamine on the cytotoxicity of four alkylating agents in vitro

31 March 2020

1 reference

Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme.

31 March 2020

1 reference

Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study

31 March 2020

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Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors

31 March 2020

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31 March 2020

12 December 2020

Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme

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Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide

31 March 2020

1 reference

Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia

31 March 2020

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In vitro effects of natural plant polyphenols on the proliferation of normal and abnormal human lymphocytes and their secretions of interleukin-2.

31 March 2020

1 reference

Phloretin-induced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport.

31 March 2020

1 reference

Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor.

31 March 2020

1 reference

Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

31 March 2020

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Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted

31 March 2020

1 reference

Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells

31 March 2020

1 reference

Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells

31 March 2020

1 reference

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth.

31 March 2020

1 reference

Pyruvate kinase type M2 and its role in tumor growth and spreading

31 March 2020

1 reference

Pyruvate kinase M2 is a phosphotyrosine-binding protein

31 March 2020

1 reference

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

31 March 2020

1 reference

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

31 March 2020

1 reference

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

31 March 2020

1 reference

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

31 March 2020

1 reference

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

31 March 2020

1 reference

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells

31 March 2020

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Cancer patients opt for unapproved drug.

31 March 2020

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pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution

31 March 2020

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Cytostatic potential of novel agents that inhibit the regulation of intracellular pH.

31 March 2020

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Acid-mediated tumor invasion: a multidisciplinary study

31 March 2020

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Hypoxia and adaptive landscapes in the evolution of carcinogenesis

31 March 2020

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Nm23-transfected MDA-mB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: A31P nuclear magnetic resonance study in vivo and in vitro

31 March 2020

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31 March 2020

12 December 2020

Acidic pH enhances the invasive behavior of human melanoma cells

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Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2.

31 March 2020

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Bicarbonate increases tumor pH and inhibits spontaneous metastases

31 March 2020

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Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH.

31 March 2020

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Indisulam: an anticancer sulfonamide in clinical development

31 March 2020

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Carbonic anhydrase inhibitors: sulfonamides as antitumor agents?

31 March 2020

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Carbonic anhydrase inhibitors. Inhibition of isoforms I, II, IV, VA, VII, IX, and XIV with sulfonamides incorporating fructopyranose–thioureido tails

31 March 2020

1 reference

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

31 March 2020

1 reference

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

31 March 2020

1 reference

Glutamine in neoplastic cells: focus on the expression and roles of glutaminases

31 March 2020

1 reference

Treatment of episodic hyperammonemia in children with inborn errors of urea synthesis

31 March 2020

1 reference

Waste nitrogen excretion via amino acid acylation: benzoate and phenylacetate in lysinuric protein intolerance

31 March 2020

1 reference

Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate

31 March 2020

1 reference

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

31 March 2020

1 reference

l-Asparaginase resistance in human leukemia—Asparagine synthetase

31 March 2020

1 reference

L-asparaginase: therapeutic and toxic effects in patients with neoplastic disease

31 March 2020

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GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

31 March 2020

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Pegasparaginase: where do we stand?

31 March 2020

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Controlling cancer by restricting arginine availability--arginine-catabolizing enzymes as anticancer agents

31 March 2020

1 reference

Pegylated arginine deiminase: a novel anticancer enzyme agent

31 March 2020

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Arginine deiminase, a potential anti-tumor drug

31 March 2020

1 reference

Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies

31 March 2020

1 reference

ATP citrate lyase inhibition can suppress tumor cell growth

31 March 2020

1 reference

Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients

31 March 2020

1 reference

Binding site of cerulenin in fatty acid synthetase

31 March 2020

1 reference

Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity

31 March 2020

1 reference

Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the beta-ketoacyl reductase reaction.

31 March 2020

1 reference

C75 is converted to C75-CoA in the hypothalamus, where it inhibits carnitine palmitoyltransferase 1 and decreases food intake and body weight

31 March 2020

1 reference

Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports

31 March 2020

1 reference

Growth of human gastric cancer cells in nude mice is delayed by a ketogenic diet supplemented with omega-3 fatty acids and medium-chain triglycerides.

31 March 2020

1 reference

Targeting energy metabolism in brain cancer: review and hypothesis

31 March 2020

1 reference

Targeting energy metabolism in brain cancer with calorically restricted ketogenic diets

31 March 2020

1 reference

The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer

31 March 2020

1 reference

Mitochondrial tumour suppressors: a genetic and biochemical update

31 March 2020

1 reference

Glycobiology and cancer: meeting summary and future diections

31 March 2020

1 reference

Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha

31 March 2020

1 reference

Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478.

31 March 2020

1 reference

Metabolite changes in HT-29 xenograft tumors following HIF-1alpha inhibition with PX-478 as studied by MR spectroscopy in vivo and ex vivo

31 March 2020

1 reference

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

31 March 2020

1 reference

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor

31 March 2020

1 reference

Bioreductive drugs: from concept to clinic

31 March 2020

1 reference

Can gene therapy overcome the problem of hypoxia in radiotherapy?

31 March 2020

1 reference

Can engineered bacteria help control cancer?

31 March 2020

1 reference

Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis

31 March 2020

1 reference

Perturbations of the AKT signaling pathway in human cancer

31 March 2020

1 reference

Defining the role of mTOR in cancer

31 March 2020

1 reference

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

31 March 2020

1 reference

Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma

31 March 2020

1 reference

Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer.

31 March 2020

1 reference

Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study.

31 March 2020

1 reference

Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer

31 March 2020

1 reference

Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

31 March 2020

1 reference

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

31 March 2020

1 reference

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

31 March 2020

1 reference

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

31 March 2020

1 reference

Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors.

31 March 2020

1 reference

First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meeting

31 March 2020

1 reference

Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid

31 March 2020

1 reference

The histological structure of some human lung cancers and the possible implications for radiotherapy

31 March 2020

1 reference

Purification and characterization of hypoxia-inducible factor 1

31 March 2020

1 reference

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

31 March 2020

1 reference

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

31 March 2020

1 reference

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

31 March 2020

1 reference

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

31 March 2020

1 reference

Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells.

31 March 2020

1 reference

12 December 2020

Tumor growth in patients with tuberous sclerosis complex on the ketogenic diet

1 reference

12 December 2020

Oxidation of C14-labeled carbohydrate intermediates in tumor and normal tissue

1 reference

12 December 2020

Selective activity of phenylacetate against malignant gliomas: resemblance to fetal brain damage in phenylketonuria.

1 reference

12 December 2020

Pharmacological blockade of fatty acid synthase (FASN) reverses acquired autoresistance to trastuzumab (Herceptin by transcriptionally inhibiting 'HER2 super-expression' occurring in high-dose trastuzumab-conditioned SKBR3/Tzb100 breast cancer cells

1 reference

12 December 2020

The efficacy of phloridzin and phloretin on tumor cell growth

1 reference

12 December 2020

Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.

1 reference

12 December 2020

Certain metabolic and pharmacologic effects in cancer patients given infusions of 2-deoxy-D-glucose

1 reference

12 December 2020

A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection

1 reference

12 December 2020

Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

1 reference

12 December 2020

Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines

1 reference

12 December 2020

First-line treatment of acute lymphoblastic leukemia with pegasparaginase.

1 reference

12 December 2020

Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts

1 reference

12 December 2020

Salvage capacity of hepatoma 3924A and action of dipyridamole

1 reference

12 December 2020

Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53.

1 reference

12 December 2020

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane

1 reference

12 December 2020

Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors.

1 reference

12 December 2020

High expression of inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2; PFKFB3) in human cancers

1 reference

12 December 2020

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

1 reference

12 December 2020

Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia.

1 reference

12 December 2020

Studies on the carbohydrate and protein metabolism of the rat hepatoma.

1 reference

12 December 2020

Induction of erythroid differentiation and fetal hemoglobin production in human leukemic cells treated with phenylacetate

1 reference

12 December 2020

Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture.

1 reference

12 December 2020

Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer

1 reference

12 December 2020

Inhibition of Fatty Acid Synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells.

1 reference

12 December 2020