(Q37718002)

22 August 2017

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title

MYC as a regulator of ribosome biogenesis and protein synthesis (English)

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22 August 2017

1

Jan van Riggelen

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22 August 2017

Alper Yetil

2

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PubMed ID

20332779

22 August 2017

Dean W Felsher

series ordinal

3

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PubMed ID

20332779

22 August 2017

language of work or name

English

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publication date

1 April 2010

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22 August 2017

Nature Reviews Cancer

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22 August 2017

10

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22 August 2017

301-309

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22 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrc2819

22 August 2017

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cites work

The many faces of c-MYC.

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31 March 2020

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The c-Myc target gene network

31 March 2020

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The Myc/Max/Mad network and the transcriptional control of cell behavior

31 March 2020

1 reference

Transcriptional regulation and transformation by Myc proteins

31 March 2020

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c-Myc target genes involved in cell growth, apoptosis, and metabolism

31 March 2020

1 reference

Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation.

31 March 2020

1 reference

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.

31 March 2020

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Myc influences global chromatin structure.

31 March 2020

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Transcription-independent functions of MYC: regulation of translation and DNA replication

31 March 2020

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Non-transcriptional control of DNA replication by c-Myc

31 March 2020

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c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

31 March 2020

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Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development.

31 March 2020

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Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer

31 March 2020

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c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription.

31 March 2020

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Global mapping of c-Myc binding sites and target gene networks in human B cells

31 March 2020

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Genomic targets of the human c-Myc protein

31 March 2020

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Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network

31 March 2020

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Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

31 March 2020

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Sequence-specific DNA binding by the c-Myc protein

31 March 2020

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MYC recruits the TIP60 histone acetyltransferase complex to chromatin

31 March 2020

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The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc

31 March 2020

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Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

31 March 2020

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An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3

31 March 2020

1 reference

TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

31 March 2020

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Repression of p15INK4b expression by Myc through association with Miz-1

31 March 2020

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Myc represses transcription through recruitment of DNA methyltransferase corepressor

31 March 2020

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Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

31 March 2020

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Max-independent functions of Myc in Drosophila melanogaster.

31 March 2020

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Direct activation of RNA polymerase III transcription by c-Myc

31 March 2020

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Myc goes global: new tricks for an old oncogene.

31 March 2020

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Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

31 March 2020

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Emerging functions of ribosomal proteins in gene-specific transcription and translation

31 March 2020

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Recent mechanistic insights into eukaryotic ribosomes

31 March 2020

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A role for c-Myc in the regulation of ribosomal RNA processing

31 March 2020

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Pre-ribosomes on the road from the nucleolus to the cytoplasm

31 March 2020

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A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders

31 March 2020

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Specific nucleolar and nucleoplasmic RNA polymerases

31 March 2020

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Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease

31 March 2020

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Multiple ribosomal RNA cleavage pathways in mammalian cells

31 March 2020

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Role of DNA-dependent RNA polymerase 3 in the transcription of the tRNA and 5S RNA genes

31 March 2020

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Molecular mechanisms of translational control

31 March 2020

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A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo

31 March 2020

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Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.

31 March 2020

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Functional diversity of the eukaryotic translation initiation factors belonging to eIF4 families

31 March 2020

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Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo.

31 March 2020

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Preferential translation of internal ribosome entry site-containing mRNAs during the mitotic cycle in mammalian cells

31 March 2020

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Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

31 March 2020

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Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response.

31 March 2020

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Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation

31 March 2020

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The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival.

31 March 2020

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Global growth deficiencies in mice lacking the ribosomal protein HIP/RPL29

31 March 2020

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Repression of HIP/RPL29 expression induces differentiation in colon cancer cells

31 March 2020

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Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint

31 March 2020

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

31 March 2020

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Does the ribosome translate cancer?

31 March 2020

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Altered cellular responses by varying expression of a ribosomal protein gene: sequential coordination of enhancement and suppression of ribosomal protein S3a gene expression induces apoptosis

31 March 2020

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Inhibition of c-Myc activity by ribosomal protein L11

31 March 2020

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Regulation of HDM2 activity by the ribosomal protein L11

31 March 2020

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Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

31 March 2020

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Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

31 March 2020

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Feedback regulation of c-Myc by ribosomal protein L11

31 March 2020

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Control of cell growth by c-Myc in the absence of cell division

31 March 2020

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c-Myc enhances protein synthesis and cell size during B lymphocyte development

31 March 2020

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Drosophila myc regulates cellular growth during development.

31 March 2020

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dMyc is required for larval growth and endoreplication in Drosophila

31 March 2020

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The transcriptional program of a human B cell line in response to Myc

31 March 2020

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Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo

31 March 2020

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Developmental context determines latency of MYC-induced tumorigenesis

31 March 2020

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c-Myc regulates mammalian body size by controlling cell number but not cell size.

31 March 2020

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N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis

31 March 2020

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Characterization of nucleophosmin (B23) as a Myc target by scanning chromatin immunoprecipitation

31 March 2020

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TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter.

31 March 2020

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MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

31 March 2020

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The Myc trilogy: lord of RNA polymerases.

31 March 2020

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c-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells

31 March 2020

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Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis

31 March 2020

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Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome

31 March 2020

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eIF-4E expression and its role in malignancies and metastases.

31 March 2020

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The RNA polymerase I transcription machinery

31 March 2020

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Dynamic epigenetic states of ribosomal RNA promoters during the cell cycle

31 March 2020

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Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling

31 March 2020

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UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery.

31 March 2020

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Upstream binding factor association induces large-scale chromatin decondensation

31 March 2020

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UBF activates RNA polymerase I transcription by stimulating promoter escape.

31 March 2020

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Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

31 March 2020

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Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail.

31 March 2020

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Identifying genes regulated in a Myc-dependent manner

31 March 2020

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Nucleolin functions in the first step of ribosomal RNA processing.

31 March 2020

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The ribonuclease activity of nucleolar protein B23.

31 March 2020

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Nucleolar protein B23 has molecular chaperone activities

31 March 2020

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The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype

31 March 2020

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Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation

31 March 2020

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Role of nucleophosmin in embryonic development and tumorigenesis

31 March 2020

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Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability

31 March 2020

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A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth

31 March 2020

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Inhibition of HDM2 and activation of p53 by ribosomal protein L23

31 March 2020

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The role of c-myc in regulation of translation initiation

31 March 2020

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Specific regulation of mRNA cap methylation by the c-Myc and E2F1 transcription factors

31 March 2020

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Tumor dormancy and MYC inactivation: pushing cancer to the brink of normalcy

31 March 2020

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Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

31 March 2020

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The gene encoding ribosomal protein S19 is mutated in Diamond-Blackfan anaemia

31 March 2020

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Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome

31 March 2020

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The human ribosomal protein L6 gene in a critical region for Noonan syndrome

31 March 2020

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Several genes encoding ribosomal proteins are over-expressed in prostate-cancer cell lines: confirmation of L7a and L37 over-expression in prostate-cancer tissue samples

31 March 2020

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Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix

31 March 2020

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Cloning and characterization of full-length human ribosomal protein L15 cDNA which was overexpressed in esophageal cancer

31 March 2020

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Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma

31 March 2020

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation

31 March 2020

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Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.

31 March 2020

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Reversible tumorigenesis by MYC in hematopoietic lineages

31 March 2020

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Sustained loss of a neoplastic phenotype by brief inactivation of MYC

31 March 2020

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MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer

31 March 2020

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The Myc-nucleophosmin-ARF network: a complex web unveiled

31 March 2020

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31 March 2020

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Translating the Histone Code

31 March 2020

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The language of covalent histone modifications

31 March 2020

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Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein

31 March 2020

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Enhanced expression of S8, L12, L23a, L27 and L30 ribosomal protein mRNAs in human hepatocellular carcinoma

31 March 2020

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12 December 2020

High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2.

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12 December 2020

Activation of the ribosomal protein L13 gene in human gastrointestinal cancer.

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12 December 2020

DNA binding activities of c-Myc purified from eukaryotic cells

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12 December 2020

Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination.

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12 December 2020

Heparin/heparan sulfate interacting protein gene expression is up-regulated in human colorectal carcinoma and correlated with differentiation status and metastasis

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12 December 2020

Ribosomal protein insufficiency and the minute syndrome in Drosophila: a dose-response relationship.

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12 December 2020

Identifiers

DOI

10.1038/NRC2819

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22 August 2017

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PubMed ID

20332779