(Q37753018)

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Signaling by NOTCH1 in Cancer

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2644603)

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1 reference

8 July 2022

Diseases of signal transduction by growth factor receptors and second messengers

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-2644603

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Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

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8 July 2022

Signaling by NOTCH1 HD Domain Mutants in Cancer

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8 July 2022

Signaling by NOTCH1 PEST Domain Mutants in Cancer

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8 July 2022

Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer

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8 July 2022

FBXW7 Mutants and NOTCH1 in Cancer

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8 July 2022

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

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8 July 2022

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

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8 July 2022

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

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8 July 2022

The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

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8 July 2022

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

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8 July 2022

Notch inhibition as a promising new approach to cancer therapy

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8 July 2022

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

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8 July 2022

The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

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8 July 2022

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

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8 July 2022

Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes

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8 July 2022

Notch activity influences the alphabeta versus gammadelta T cell lineage decision

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8 July 2022

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

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8 July 2022

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

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8 July 2022

Requirement for Notch1 signals at sequential early stages of intrathymic T cell development

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8 July 2022

Notch signaling controls the generation and differentiation of early T lineage progenitors

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8 July 2022

FBXW7/hCDC4 is a general tumor suppressor in human cancer.

1 reference

8 July 2022

Identifiers

1 reference

8 July 2022

(Q37753018)

Signaling by NOTCH1 in Cancer

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