(Q37760038)

22 August 2017

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title

TGFbeta signalling: a complex web in cancer progression (English)

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22 August 2017

Hiroaki Ikushima

1

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22 August 2017

Kohei Miyazono

series ordinal

2

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22 August 2017

language of work or name

English

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publication date

1 June 2010

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22 August 2017

Nature Reviews Cancer

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22 August 2017

10

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22 August 2017

415-424

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22 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nrc2853

22 August 2017

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cites work

Role of transforming growth factor beta in human disease

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Alterations in components of the TGF-beta superfamily signaling pathways in human cancer

31 March 2020

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Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

31 March 2020

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High levels of transforming growth factor beta 1 in patients with colorectal cancer: association with disease progression

31 March 2020

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Transforming growth factor beta1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer

31 March 2020

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Transforming growth factor beta1 in ductal carcinoma in situ and invasive carcinomas of the breast

31 March 2020

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Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

31 March 2020

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Transforming growth factor-beta regulation of immune responses

31 March 2020

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

31 March 2020

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

31 March 2020

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Specificity and versatility in tgf-beta signaling through Smads

31 March 2020

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Making sense of latent TGFbeta activation

31 March 2020

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Latent transforming growth factor-beta (TGF-beta) binding proteins: orchestrators of TGF-beta availability

31 March 2020

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Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling

31 March 2020

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Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth

31 March 2020

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

31 March 2020

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Two major Smad pathways in TGF-beta superfamily signalling.

31 March 2020

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Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling.

31 March 2020

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Promoter-wide analysis of Smad4 binding sites in human epithelial cells.

31 March 2020

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An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling

31 March 2020

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31 March 2020

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Cellular context-dependent "colors" of transforming growth factor-beta signaling

31 March 2020

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TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

31 March 2020

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The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

31 March 2020

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E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

31 March 2020

1 reference

Non-Smad TGF-beta signals

31 March 2020

1 reference

Non-Smad pathways in TGF-beta signaling

31 March 2020

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Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

31 March 2020

1 reference

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

31 March 2020

1 reference

c-myc is a downstream target of the Smad pathway

31 March 2020

1 reference

4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation

31 March 2020

1 reference

Ski and SnoN, potent negative regulators of TGF-beta signaling

31 March 2020

1 reference

c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements

31 March 2020

1 reference

SnoN functions as a tumour suppressor by inducing premature senescence

31 March 2020

1 reference

Dual role of SnoN in mammalian tumorigenesis

31 March 2020

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Ski promotes tumor growth through abrogation of transforming growth factor-beta signaling in pancreatic cancer

31 March 2020

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Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26

31 March 2020

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The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3

31 March 2020

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SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells

31 March 2020

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Molecular pathogenesis of non-Hodgkin's lymphoma: the role of Bcl-6

31 March 2020

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31 March 2020

12 December 2020

BCL6 represses Smad signaling in transforming growth factor-beta resistance

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Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.

31 March 2020

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Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element

31 March 2020

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RUNX transcription factors as key targets of TGF-beta superfamily signaling

31 March 2020

1 reference

RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD.

31 March 2020

1 reference

The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis

31 March 2020

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TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

31 March 2020

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High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene.

31 March 2020

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Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors

31 March 2020

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TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase

31 March 2020

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Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

31 March 2020

1 reference

Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells

31 March 2020

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Bim is a suppressor of Myc-induced mouse B cell leukemia

31 March 2020

1 reference

Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1

31 March 2020

1 reference

Expression of vascular endothelial growth factor D is associated with hypoxia inducible factor (HIF-1alpha) and the HIF-1alpha target gene DEC1, but not lymph node metastasis in primary human breast carcinomas

31 March 2020

1 reference

The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers

31 March 2020

1 reference

Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.

31 March 2020

1 reference

The paradox of autophagy and its implication in cancer etiology and therapy

31 March 2020

1 reference

Stem cells, cancer, and cancer stem cells

31 March 2020

1 reference

Cancer stem cells and their niche

31 March 2020

1 reference

TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

31 March 2020

1 reference

Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model

31 March 2020

1 reference

The epithelial-mesenchymal transition generates cells with properties of stem cells

31 March 2020

1 reference

Roles of TGF-beta family signaling in stem cell renewal and differentiation

31 March 2020

1 reference

TGF-beta, neuronal stem cells and glioblastoma

31 March 2020

1 reference

TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma.

31 March 2020

1 reference

Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.

31 March 2020

1 reference

Pairing SOX off: with partners in the regulation of embryonic development

31 March 2020

1 reference

SOX2 functions to maintain neural progenitor identity

31 March 2020

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Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain

31 March 2020

1 reference

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

31 March 2020

1 reference

Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma

31 March 2020

1 reference

Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies

31 March 2020

1 reference

Noggin antagonizes BMP signaling to create a niche for adult neurogenesis

31 March 2020

1 reference

Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

31 March 2020

1 reference

Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells

31 March 2020

1 reference

TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

31 March 2020

1 reference

Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma

31 March 2020

1 reference

Excessive production of transforming growth-factor beta 1 can play an important role in the development of tumorigenesis by its action for angiogenesis: validity of neutralizing antibodies to block tumor growth

31 March 2020

1 reference

A multigenic program mediating breast cancer metastasis to bone

31 March 2020

1 reference

Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression

31 March 2020

1 reference

TGF-beta signaling in tumor suppression and cancer progression

31 March 2020

1 reference

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

31 March 2020

1 reference

Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling

31 March 2020

1 reference

c-Ski overexpression promotes tumor growth and angiogenesis through inhibition of transforming growth factor-beta signaling in diffuse-type gastric carcinoma.

31 March 2020

1 reference

Epithelial-mesenchymal transitions in tumour progression

31 March 2020

1 reference

Epithelial-mesenchymal transitions in development and disease

31 March 2020

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Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

31 March 2020

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Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

31 March 2020

1 reference

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

31 March 2020

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TGF-beta-induced epithelial to mesenchymal transition

31 March 2020

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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

31 March 2020

1 reference

Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways

31 March 2020

1 reference

TGFbeta-induced downregulation of E-cadherin-based cell-cell adhesion depends on PI3-kinase and PTEN.

31 March 2020

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Role of Ras signaling in the induction of snail by transforming growth factor-beta.

31 March 2020

1 reference

TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer

31 March 2020

1 reference

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

31 March 2020

1 reference

Smad signaling is required to maintain epigenetic silencing during breast cancer progression.

31 March 2020

1 reference

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

31 March 2020

1 reference

Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer

31 March 2020

1 reference

BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo

31 March 2020

1 reference

Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells

31 March 2020

1 reference

Transforming growth factor-beta inhibits pulmonary surfactant protein B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors

31 March 2020

1 reference

SMAD3 prevents binding of NKX2.1 and FOXA1 to the SpB promoter through its MH1 and MH2 domains

31 March 2020

1 reference

Thyroid transcription factor-1 expression prevalence and its clinical implications in non-small cell lung cancer: a high-throughput tissue microarray and immunohistochemistry study.

31 March 2020

1 reference

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

31 March 2020

1 reference

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis

31 March 2020

1 reference

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

31 March 2020

1 reference

Cyclic adenosine monophosphate/protein kinase A mediates parathyroid hormone/parathyroid hormone-related protein receptor regulation of osteoclastogenesis and expression of RANKL and osteoprotegerin mRNAs by marrow stromal cells

31 March 2020

1 reference

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

31 March 2020

1 reference

Molecular biology of bone metastasis

31 March 2020

1 reference

Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line.

31 March 2020

1 reference

Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor

31 March 2020

1 reference

Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor- Type I Receptor Kinase In vivo

31 March 2020

1 reference

The two faces of transforming growth factor beta in carcinogenesis

31 March 2020

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Development of TGF-beta signalling inhibitors for cancer therapy

31 March 2020

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Targeted tumor therapy with the TGF-beta 2 antisense compound AP 12009.

31 March 2020

1 reference

Identification of multipotent mesenchymal stromal cells in the reactive stroma of a prostate cancer xenograft by side population analysis

31 March 2020

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Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.

31 March 2020

1 reference

Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma

31 March 2020

1 reference

12 December 2020

Inhibition of transforming growth factor-beta activity decreases angiogenesis in a human prostate cancer-reactive stroma xenograft model

1 reference

12 December 2020

A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells

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12 December 2020

A subset of metastatic human colon cancers expresses elevated levels of transforming growth factor beta1.

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12 December 2020

High levels of transforming growth factor beta 1 correlate with disease progression in human colon cancer

1 reference

12 December 2020

SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells

1 reference

12 December 2020

Role of interleukin 10 and transforming growth factor beta1 in the angiogenesis and metastasis of human prostate primary tumor lines from orthotopic implants in severe combined immunodeficiency mice

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12 December 2020

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

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12 December 2020

Pathogenetic role of BCL6 translocation in B-cell non-Hodgkin's lymphoma

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12 December 2020

Identifiers

DOI

10.1038/NRC2853

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release_uscgubwegrd4vnask3746gcx5q

22 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/uscgubwegrd4vnask3746gcx5q

24 November 2022

mapped directly with Wikidata item

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