(Q37774852)

23 August 2017

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title

Targeting the ANGPT-TIE2 pathway in malignancy (English)

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23 August 2017

Hanhua Huang

1

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23 August 2017

Abhijit Bhat

series ordinal

2

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23 August 2017

Gary Woodnutt

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3

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23 August 2017

Rodney Lappe

series ordinal

4

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23 August 2017

language of work or name

English

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publication date

1 August 2010

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23 August 2017

Nature Reviews Cancer

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23 August 2017

10

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23 August 2017

575-585

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23 August 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrc2894

23 August 2017

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cites work

Evading tumor evasion: current concepts and perspectives of anti-angiogenic cancer therapy

1 reference

Modes of resistance to anti-angiogenic therapy

31 March 2020

1 reference

Tumor and host-mediated pathways of resistance and disease progression in response to antiangiogenic therapy.

31 March 2020

1 reference

Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors

31 March 2020

1 reference

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

31 March 2020

1 reference

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

31 March 2020

1 reference

Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium

31 March 2020

1 reference

A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis.

31 March 2020

1 reference

Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway

31 March 2020

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Biological characterization of angiopoietin-3 and angiopoietin-4

31 March 2020

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Angiopoietin-3 inhibits pulmonary metastasis by inhibiting tumor angiogenesis

31 March 2020

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Angiopoietin-4 inhibits angiogenesis and reduces interstitial fluid pressure

31 March 2020

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Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells

31 March 2020

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Roles of the receptor tyrosine kinases Tie1 and Tie2 in mediating the effects of angiopoietin-1 on endothelial permeability and apoptosis

31 March 2020

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Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2

31 March 2020

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Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex

31 March 2020

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Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2.

31 March 2020

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A unique autophosphorylation site on Tie2/Tek mediates Dok-R phosphotyrosine binding domain binding and function

31 March 2020

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The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

31 March 2020

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Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration

31 March 2020

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Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands

31 March 2020

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Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis

31 March 2020

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VE-PTP controls blood vessel development by balancing Tie-2 activity

31 March 2020

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Angiopoietin-2 impairs revascularization after limb ischemia

31 March 2020

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Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

31 March 2020

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Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2.

31 March 2020

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Angiopoietin-2: development of inhibitors for cancer therapy

31 March 2020

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The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

31 March 2020

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Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells

31 March 2020

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Secretion pores in human endothelial cells during acute hypoxia.

31 March 2020

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Dynamics and plasticity of Weibel-Palade bodies in endothelial cells

31 March 2020

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Expression and prognostic significance of angiopoietin in colorectal carcinoma

31 March 2020

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Expression of angiopoietin-1 and -2, and its clinical significance in human bladder cancer

31 March 2020

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Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia

31 March 2020

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Shedding of the endothelial receptor tyrosine kinase Tie2 correlates with leukemic blast burden and outcome after allogeneic hematopoietic stem cell transplantation for AML.

31 March 2020

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Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: expression of angiopoietin-2 represents an independent prognostic factor for overall survival

31 March 2020

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Angiopoietin-2 expression in breast cancer correlates with lymph node invasion and short survival.

31 March 2020

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Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma

31 March 2020

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Hepatic expression of ANG2 RNA in metastatic colorectal cancer

31 March 2020

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Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib

31 March 2020

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Circulating angiopoietin-2 is elevated in patients with neuroendocrine tumours and correlates with disease burden and prognosis

31 March 2020

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The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas

31 March 2020

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Angiopoietin 2 expression is related to histological grade, vascular density, metastases, and outcome in prostate cancer

31 March 2020

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Expression of the angopoietin-1, angopoietin-2, Tie2, and vascular endothelial growth factor gene in epithelial ovarian cancer.

31 March 2020

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Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth

31 March 2020

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Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo

31 March 2020

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Tipping the balance: robustness of tip cell selection, migration and fusion in angiogenesis

31 March 2020

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VEGF and endothelial guidance in angiogenic sprouting

31 March 2020

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The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

31 March 2020

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Jagged gives endothelial tip cells an edge

31 March 2020

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VEGF and Notch signaling: the yin and yang of angiogenic sprouting

31 March 2020

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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

31 March 2020

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DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

31 March 2020

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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

31 March 2020

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Delta-like 4/Notch signaling and its therapeutic implications

31 March 2020

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Egfl7 knockdown causes defects in the extension and junctional arrangements of endothelial cells during zebrafish vasculogenesis

31 March 2020

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The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation

31 March 2020

1 reference

EGFL7 meets miRNA-126: an angiogenesis alliance

31 March 2020

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Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma

31 March 2020

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Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal

31 March 2020

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Endothelial/pericyte interactions

31 March 2020

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Endothelial-mural cell signaling in vascular development and angiogenesis

31 March 2020

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Contextual role for angiopoietins and TGFbeta1 in blood vessel stabilization

31 March 2020

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Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth

31 March 2020

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Angiopoietin-1 protects the adult vasculature against plasma leakage.

31 March 2020

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Cell adhesion dynamics at endothelial junctions: VE-cadherin as a major player

31 March 2020

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Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis

31 March 2020

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VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.

31 March 2020

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Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2

31 March 2020

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Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development

31 March 2020

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Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis

31 March 2020

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Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

31 March 2020

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Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels

31 March 2020

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Angiopoietin/Tek Interactions Regulate MMP-9 Expression and Retinal Neovascularization

31 March 2020

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Angiopoietin-2 facilitates vascular endothelial growth factor-induced angiogenesis in the mature mouse brain

31 March 2020

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Novel insights of the gastric gland organization revealed by chief cell specific expression of moesin

31 March 2020

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Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

31 March 2020

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Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1

31 March 2020

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Tie2 is tied at the cell-cell contacts and to extracellular matrix by angiopoietin-1

31 March 2020

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Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

31 March 2020

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Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice.

31 March 2020

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Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation.

31 March 2020

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In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin

31 March 2020

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Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation.

31 March 2020

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Angiopoietin-1 promotes lymphatic sprouting and hyperplasia.

31 March 2020

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Tumor-derived lymphangiogenic factors and lymphatic metastasis.

31 March 2020

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Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis

31 March 2020

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Preoperative serum angiopoietin-2 levels correlate with lymph node status in patients with early gastric cancer.

31 March 2020

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Pericytes: gatekeepers in tumour cell metastasis?

31 March 2020

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Pericytes limit tumor cell metastasis

31 March 2020

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Angiopoietin-2 stimulates breast cancer metastasis through the alpha(5)beta(1) integrin-mediated pathway

31 March 2020

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Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma.

31 March 2020

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Serum angiopoietin-2 as a clinical marker for lung cancer.

31 March 2020

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Angiopoietin 2 expression in invasive ductal carcinoma of the breast: its relationship to the VEGF expression and microvessel density.

31 March 2020

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Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2.

31 March 2020

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Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis

31 March 2020

1 reference

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation

31 March 2020

1 reference

Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer

31 March 2020

1 reference

Cancer-related inflammation

31 March 2020

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Cancer research. Inflammation and cancer: the link grows stronger

31 March 2020

1 reference

Angiopoietin/Tie2 signaling, tumor angiogenesis and inflammatory diseases

31 March 2020

1 reference

Bench-to-bedside review: Angiopoietin signalling in critical illness - a future target?

31 March 2020

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Protective role of angiopoietin-1 in endotoxic shock.

31 March 2020

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Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis

31 March 2020

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Angiopoietin-1 variant, COMP-Ang1 attenuates hydrogen peroxide-induced acute lung injury

31 March 2020

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The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2.

31 March 2020

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ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1

31 March 2020

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Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression

31 March 2020

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Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells

31 March 2020

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Potential role of soluble angiopoietin-2 and Tie-2 in patients with inflammatory bowel disease

31 March 2020

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Altered expression of angiopoietins and Tie2 endothelium receptor in psoriasis

31 March 2020

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Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death

31 March 2020

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The role of angiopoietin 2 in hyperoxia-induced acute lung injury

31 March 2020

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Angiopoietin-2: modulator of vascular permeability in acute lung injury?

31 March 2020

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Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak.

31 March 2020

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Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans

31 March 2020

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The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients

31 March 2020

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Myeloid cells functioning in tumor vascularization as a novel therapeutic target

31 March 2020

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Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

31 March 2020

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Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.

31 March 2020

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Expression of Tie-2 by human monocytes and their responses to angiopoietin-2

31 March 2020

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Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2.

31 March 2020

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Discontinued drugs in 2007: oncology drugs

31 March 2020

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Expression and function of angiopoietin-1 in breast cancer.

31 March 2020

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Stabilization of breast cancer xenograft tumour neovasculature by angiopoietin-1.

31 March 2020

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Activation of the tie2 receptor by angiopoietin-1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth

31 March 2020

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Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment.

31 March 2020

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Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth

31 March 2020

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Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway

31 March 2020

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Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

31 March 2020

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Phase 1 study of AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adults with advanced solid tumors

31 March 2020

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Angiopoietin 2 displays a vascular endothelial growth factor dependent synergistic effect in hepatocellular carcinoma development in mice.

31 March 2020

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Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis

31 March 2020

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Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

31 March 2020

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A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models

31 March 2020

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Human epidermal growth factor receptor 2 regulates angiopoietin-2 expression in breast cancer via AKT and mitogen-activated protein kinase pathways

31 March 2020

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HER2 regulatory control of angiopoietin-2 in breast cancer

31 March 2020

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Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats

31 March 2020

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A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains

31 March 2020

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Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival

31 March 2020

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Inhibition of in vivo tumor angiogenesis and growth via systemic delivery of an angiopoietin 2-specific RNA aptamer

31 March 2020

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Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta

31 March 2020

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12 December 2020

Expression of angiopoietins and its clinical significance in non-small cell lung cancer

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12 December 2020

Randomized, double-blind, placebo-controlled phase II study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer

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12 December 2020

Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors

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12 December 2020

Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts.

1 reference

12 December 2020

Construction of a ganciclovir-sensitive lentiviral vector to assess the influence of angiopoietin-3 and soluble Tie2 on glioma growth

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12 December 2020

Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas

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12 December 2020

The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer

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12 December 2020

Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer

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12 December 2020

Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.

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12 December 2020

Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases

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12 December 2020

[Significance of a reversal expression of the angiopoietin-1 and 2 in oral squamous cell carcinoma]

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12 December 2020

Angiopoietin-2 overexpression in morris hepatoma results in increased tumor perfusion and induction of critical angiogenesis-promoting genes.

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12 December 2020

Inflammatory cytokines and vascular endothelial growth factor stimulate the release of soluble tie receptor from human endothelial cells via metalloprotease activation

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12 December 2020

Identifiers

DOI

10.1038/NRC2894

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23 August 2017

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