(Q37778780)

23 August 2017

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title

Triosephosphate isomerase: a highly evolved biocatalyst (English)

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23 August 2017

R K Wierenga

1

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PubMed ID

20694739

23 August 2017

E G Kapetaniou

series ordinal

2

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PubMed ID

20694739

23 August 2017

R Venkatesan

series ordinal

3

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23 August 2017

7 August 2010

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Cellular and Molecular Life Sciences

23 August 2017

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23 August 2017

67

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23 August 2017

3961-3982

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23 August 2017

23

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https://scigraph.springernature.com/pub.10.1007/s00018-010-0473-9

23 August 2017

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cites work

Enzyme-substrate and enzyme-inhibitor complexes of triose phosphate isomerase studied by 31P nuclear magnetic resonance

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00018-010-0473-9

Triosephosphate isomerase deficiency: new insights into an enigmatic disease

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00018-010-0473-9

Evolution of alpha-amylases: architectural features and key residues in the stabilization of the (beta/alpha)(8) scaffold

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00018-010-0473-9

Xylose isomerase in substrate and inhibitor michaelis states: atomic resolution studies of a metal-mediated hydride shift

21 January 2018

1 reference

12 December 2020

Critical ionization states in the reaction catalyzed by triosephosphate isomerase

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12 December 2020

Transition State Analogues for Enzyme Catalysis

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12 December 2020

Influence of pH on the interaction of inhibitors with triosephosphate isomerase and determination of the pKa of the active-site carboxyl group

1 reference

12 December 2020

Mechanistic imperatives for aldose-ketose isomerization in water: specific, general base- and metal ion-catalyzed isomerization of glyceraldehyde with proton and hydride transfer

1 reference

12 December 2020

Uncatalyzed rates of enolization of dihydroxyacetone phosphate and of glyceraldehyde 3-phosphate in neutral aqueous solution. Quantitative assessment of the effectiveness of an enzyme catalyst

1 reference

12 December 2020

New inhibitors of rabbit muscle triose-phosphate isomerase

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12 December 2020

Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR.

1 reference

12 December 2020

Proton diffusion in the active site of triosephosphate isomerase

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12 December 2020

Modeling, mutagenesis, and structural studies on the fully conserved phosphate-binding loop (loop 8) of triosephosphate isomerase: toward a new substrate specificity

1 reference

12 December 2020

Inactivation of Muscle Triose Phosphate Isomerase by d- and l-Glycidol Phosphate

1 reference

12 December 2020

Contribution of phosphate intrinsic binding energy to the enzymatic rate acceleration for triosephosphate isomerase

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12 December 2020

The orientation and accessibility of substrates on the active site of triosephosphate isomerase

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12 December 2020

Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway

1 reference

12 December 2020

Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei

1 reference

12 December 2020

Triosephosphate isomerase deficiency: facts and doubts

1 reference

12 December 2020

Structure of the Plasmodium falciparum triosephosphate isomerase-phosphoglycolate complex in two crystal forms: characterization of catalytic loop open and closed conformations in the ligand-bound state

1 reference

12 December 2020

Structural determinants for ligand binding and catalysis of triosephosphate isomerase

1 reference

12 December 2020

Active-site labelling of triose phosphate isomerase. The reaction of bromohydroxyacetone phosphate with a unique glutamic acid residue and the migration of the label to tyrosine

1 reference

12 December 2020

Structures of the "open" and "closed" state of trypanosomal triosephosphate isomerase, as observed in a new crystal form: implications for the reaction mechanism

1 reference

12 December 2020

Backbone makes a significant contribution to the electrostatics of alpha/beta-barrel proteins.

1 reference

12 December 2020

Homology among (betaalpha)(8) barrels: implications for the evolution of metabolic pathways

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12 December 2020

Triosephosphate isomerase requires a positively charged active site: the role of lysine-12

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12 December 2020

Mechanism of the Aldose‐Ketose Isomerase Reactions

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12 December 2020

Triosephosphate isomerase: removal of a putatively electrophilic histidine residue results in a subtle change in catalytic mechanism

1 reference

12 December 2020

Role of loop-loop interactions in coordinating motions and enzymatic function in triosephosphate isomerase.

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12 December 2020

Refined three-dimensional structure of cat-muscle (M1) pyruvate kinase at a resolution of 2.6 A

1 reference

12 December 2020

The TIM-barrel fold: a versatile framework for efficient enzymes

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12 December 2020

Neutral imidazole is the electrophile in the reaction catalyzed by triosephosphate isomerase: structural origins and catalytic implications

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12 December 2020

Energetics of triosephosphate isomerase: the fate of the 1(R)-3H label of tritiated dihydroxyacetone phsophate in the isomerase reaction

1 reference

12 December 2020

Segmental motion in catalysis: investigation of a hydrogen bond critical for loop closure in the reaction of triosephosphate isomerase

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12 December 2020

Inactivation of triosephosphate isomerase from Trypanosoma cruzi by an agent that perturbs its dimer interface

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12 December 2020

Perturbation of the Dimer Interface of Triosephosphate Isomerase and its Effect on Trypanosoma cruzi

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12 December 2020

The evolutionary origins and catalytic importance of conserved electrostatic networks within TIM-barrel proteins

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12 December 2020

Enzyme catalysis: not different, just better

1 reference

12 December 2020

Three new crystal structures of point mutation variants of monoTIM: conformational flexibility of loop-1, loop-4 and loop-8

1 reference

12 December 2020

Free-energy profile of the reaction catalyzed by triosephosphate isomerase

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12 December 2020

Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation.

1 reference

12 December 2020

Evolutionary aspects of trypanosomes: analysis of genes.

1 reference

12 December 2020

The depth of chemical time and the power of enzymes as catalysts.

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12 December 2020

Direct observation of substrate distortion by triosephosphate isomerase using Fourier transform infrared spectroscopy

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12 December 2020

Anatomy of a conformational change: hinged "lid" motion of the triosephosphate isomerase loop.

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12 December 2020

Kinetic properties of triose-phosphate isomerase from Trypanosoma brucei brucei. A comparison with the rabbit muscle and yeast enzymes

1 reference

12 December 2020

Catalytic versatility, stability, and evolution of the (betaalpha)8-barrel enzyme fold

1 reference

12 December 2020

Dynamics of the flexible loop of triosephosphate isomerase: the loop motion is not ligand gated

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12 December 2020

Triosephosphate isomerase: 15N and 13C chemical shift assignments and conformational change upon ligand binding by magic-angle spinning solid-state NMR spectroscopy

1 reference

12 December 2020

Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion

1 reference

12 December 2020

Catalysis and specificity in enzymes: a study of triosephosphate isomerase and comparison with methyl glyoxal synthase

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12 December 2020

Conformational changes in phosphoglucose isomerase induced by ligand binding

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12 December 2020

Proton transfer at carbon.

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12 December 2020

Value of a hydrogen bond in triosephosphate isomerase loop motion

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12 December 2020

Closed conformation of the active site loop of rabbit muscle triosephosphate isomerase in the absence of substrate: evidence of conformational heterogeneity

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12 December 2020

The loop opening/closing motion of the enzyme triosephosphate isomerase

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12 December 2020

Transition-state analogues in protein crystallography: probes of the structural source of enzyme catalysis

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12 December 2020

The role of water in the catalytic efficiency of triosephosphate isomerase

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12 December 2020

Different strategies to recover the activity of monomeric triosephosphate isomerase by directed evolution

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12 December 2020

Computer simulation and analysis of the reaction pathway of triosephosphate isomerase

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12 December 2020

Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution

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12 December 2020

Evolution of enzyme function and the development of catalytic efficiency

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12 December 2020

Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase.

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12 December 2020

An activated intermediate analogue. The use of phosphoglycolohydroxamate as a stable analogue of a transiently occurring dihydroxyacetone phosphate-derived enolate in enzymatic catalysis.

1 reference

12 December 2020

Structural basis of human triosephosphate isomerase deficiency: mutation E104D is related to alterations of a conserved water network at the dimer interface

1 reference

12 December 2020

Divergent evolution of (betaalpha)8-barrel enzymes.

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12 December 2020

Role of Lys-12 in catalysis by triosephosphate isomerase: a two-part substrate approach

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12 December 2020

The crystal structure of an engineered monomeric triosephosphate isomerase, monoTIM: the correct modelling of an eight-residue loop.

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12 December 2020

Computational modeling of the catalytic reaction in triosephosphate isomerase.

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12 December 2020

Inactivation and Labeling of Triose Phosphate Isomerase and Enolase by Glycidol Phosphate

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12 December 2020

Substrate product equilibrium on a reversible enzyme, triosephosphate isomerase.

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12 December 2020

Understanding the rates of certain enzyme-catalyzed reactions: proton abstraction from carbon acids, acyl-transfer reactions, and displacement reactions of phosphodiesters

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12 December 2020

Kemp elimination catalysts by computational enzyme design

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12 December 2020

The hinged lid of yeast triose-phosphate isomerase. Determination of the energy barrier between the two conformations.

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12 December 2020

Free-energy landscape of enzyme catalysis

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12 December 2020

One fold with many functions: the evolutionary relationships between TIM barrel families based on their sequences, structures and functions

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12 December 2020

Active site loop motion in triosephosphate isomerase: T-jump relaxation spectroscopy of thermal activation.

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12 December 2020

Active site properties of monomeric triosephosphate isomerase (monoTIM) as deduced from mutational and structural studies

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12 December 2020

The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase

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12 December 2020

Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle

1 reference

12 December 2020

High-resolution crystal structure of an artificial (betaalpha)(8)-barrel protein designed from identical half-barrels

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12 December 2020

Atomic resolution crystallography of a complex of triosephosphate isomerase with a reaction-intermediate analog: new insight in the proton transfer reaction mechanism

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12 December 2020

The low barrier hydrogen bond in enzymatic catalysis.

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12 December 2020

Competitive inhibitors of Mycobacterium tuberculosis ribose-5-phosphate isomerase B reveal new information about the reaction mechanism.

1 reference

12 December 2020

Haloacetol phosphates. Characterization of the active site of rabbit muscle triose phosphate isomerase

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12 December 2020

Biochemical and structural characterization of residue 96 mutants of Plasmodium falciparum triosephosphate isomerase: active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site

1 reference

12 December 2020

Design, creation, and characterization of a stable, monomeric triosephosphate isomerase

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12 December 2020

The 1591C mutation in triosephosphate isomerase (TPI) deficiency. Tightly linked polymorphisms and a common haplotype in all known families

1 reference

12 December 2020

Human triose-phosphate isomerase deficiency: a single amino acid substitution results in a thermolabile enzyme

1 reference

12 December 2020

Protein engineering with monomeric triosephosphate isomerase (monoTIM): the modelling and structure verification of a seven-residue loop

1 reference

12 December 2020

Optimal alignment for enzymatic proton transfer: structure of the Michaelis complex of triosephosphate isomerase at 1.2-A resolution.

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12 December 2020

Hydron transfer catalyzed by triosephosphate isomerase. Products of the direct and phosphite-activated isomerization of [1-(13)C]-glycolaldehyde in D(2)O.

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12 December 2020

Hydron transfer catalyzed by triosephosphate isomerase. Products of isomerization of dihydroxyacetone phosphate in D2O.

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12 December 2020

The planar conformation of a strained proline ring: a QM/MM study

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12 December 2020

Efficiency and Evolution of Enzyme Catalysis

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12 December 2020

Crystallographic analysis of the complex between triosephosphate isomerase and 2-phosphoglycolate at 2.5-A resolution: implications for catalysis

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12 December 2020

Triosephosphate isomerase deficiency: historical perspectives and molecular aspects

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12 December 2020

Proton transfer in the mechanism of triosephosphate isomerase

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12 December 2020

Directed evolution of (betaalpha)(8)-barrel enzymes

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12 December 2020

The crystal structure of triosephosphate isomerase (TIM) from Thermotoga maritima: a comparative thermostability structural analysis of ten different TIM structures

1 reference

12 December 2020

Detection of the protein dimers, multiple monomeric states and hydrated forms of Plasmodium falciparum triosephosphate isomerase in the gas phase.

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12 December 2020

The mechanistic ventures of triosephosphate isomerase

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12 December 2020

Oxyanion hole-stabilized stereospecific isomerization in ribose-5-phosphate isomerase (Rpi)

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12 December 2020

Structural principles of alpha/beta barrel proteins: the packing of the interior of the sheet

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12 December 2020

Structural and mutagenesis studies of leishmania triosephosphate isomerase: a point mutation can convert a mesophilic enzyme into a superstable enzyme without losing catalytic power

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12 December 2020

Mechanism of C-H bond cleavage in aldolase and isomerase reactions

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12 December 2020

Restoring a metabolic pathway

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12 December 2020

Phosphate binding energy and catalysis by small and large molecules

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12 December 2020

Synthetic peptides as inactivators of multimeric enzymes: inhibition of Plasmodium falciparum triosephosphate isomerase by interface peptides

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12 December 2020

Enzymatic transition state theory and transition state analogue design

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12 December 2020

Structure-based protein engineering efforts with a monomeric TIM variant: the importance of a single point mutation for generating an active site with suitable binding properties

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12 December 2020

Structure of the complex between trypanosomal triosephosphate isomerase and N‐hydroxy‐4‐phosphono‐butanamide: Binding at the active site despite an “open” flexible loop conformation

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12 December 2020

NMR studies of the role of hydrogen bonding in the mechanism of triosephosphate isomerase

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12 December 2020

Understanding protein lids: structural analysis of active hinge mutants in triosephosphate isomerase.

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12 December 2020

Functional role of the conserved active site proline of triosephosphate isomerase

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12 December 2020

Crystal structure of triosephosphate isomerase complexed with 2-phosphoglycolate at 0.83-A resolution

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12 December 2020

Establishing wild-type levels of catalytic activity on natural and artificial ( )8-barrel protein scaffolds

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12 December 2020

Structure of chicken muscle triose phosphate isomerase determined crystallographically at 2.5Å resolution: using amino acid sequence data

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12 December 2020

Triosephosphate isomerase: a theoretical comparison of alternative pathways

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12 December 2020

Secondary H/T and D/T isotope effects in enzymatic enolization reactions. Coupled motion and tunneling in the triosephosphate isomerase reaction

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12 December 2020

The crystal structure of rabbit phosphoglucose isomerase complexed with 5-phospho-D-arabinonohydroxamic acid.

1 reference

12 December 2020

10.1007/S00018-010-0473-9

Identifiers

DOI

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23 August 2017

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PubMed ID

20694739