(Q37784290)

23 August 2017

title

GRP78 signaling hub a receptor for targeted tumor therapy (English)

1 reference

23 August 2017

4

Renata Pasqualini

1 reference

23 August 2017

3

Wadih Arap

1 reference

23 August 2017

Masanori Sato

1

1 reference

23 August 2017

Virginia J Yao

series ordinal

2

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23 August 2017

publication date

1 January 2010

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23 August 2017

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23 August 2017

volume

69

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23 August 2017

page(s)

97-114

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Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands

23 August 2017

cites work

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The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis

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BiP, a putative autoantigen in rheumatoid arthritis, stimulates IL-10-producing CD8-positive T cells from normal individuals

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Antibody response to the human stress protein BiP in rheumatoid arthritis

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7 January 2021

Treatment of murine collagen-induced arthritis by the stress protein BiP via interleukin-4-producing regulatory T cells: a novel function for an ancient protein

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7 January 2021

The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis

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7 January 2021

Interaction of murine BiP/GRP78 with the DnaJ homologue MTJ1

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7 January 2021

The human endoplasmic reticulum molecular chaperone BiP is an autoantigen for rheumatoid arthritis and prevents the induction of experimental arthritis

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7 January 2021

Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78.

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7 January 2021

The 78 kDa glucose-regulated protein (GRP78/BIP) is expressed on the cell membrane, is released into cell culture medium and is also present in human peripheral circulation

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7 January 2021

Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment

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7 January 2021

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.

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7 January 2021

Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis

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7 January 2021

Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy

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7 January 2021

GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis

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7 January 2021

Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer

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7 January 2021

The Voltage-dependent Anion Channel Is a Receptor for Plasminogen Kringle 5 on Human Endothelial Cells

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7 January 2021

Prostate cancer cell proliferation in vitro is modulated by antibodies against glucose-regulated protein 78 isolated from patient serum

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7 January 2021

Plasminogen Structural Domains Exhibit Different Functions When Associated with Cell Surface GRP78 or the Voltage-dependent Anion Channel

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7 January 2021

Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signaling

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7 January 2021

Therapeutic angiogenesis of mouse hind limb ischemia by novel peptide activating GRP78 receptor on endothelial cells

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7 January 2021

Anticancer strategies involving the vasculature

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7 January 2021

GRP78 expression correlates with histologic differentiation and favorable prognosis in neuroblastic tumors.

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7 January 2021

Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer

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7 January 2021

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

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7 January 2021

T-cadherin upregulation correlates with cell-cycle progression and promotes proliferation of vascular cells

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7 January 2021

Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways

1 reference

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7 January 2021

Targeting heat shock proteins on cancer cells: selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand

1 reference

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7 January 2021

T-cadherin attenuates the PERK branch of the unfolded protein response and protects vascular endothelial cells from endoplasmic reticulum stress-induced apoptosis.

1 reference

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7 January 2021

Expression and clinical significance of glucose regulated proteins GRP78 (BiP) and GRP94 (GP96) in human adenocarcinomas of the esophagus

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7 January 2021

GRP78 induction in cancer: therapeutic and prognostic implications.

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7 January 2021

GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer

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7 January 2021

GRP78 is overexpressed in glioblastomas and regulates glioma cell growth and apoptosis

1 reference

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7 January 2021

Stress induction of GRP78/BiP and its role in cancer.

1 reference

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7 January 2021

In Vivo Interrogation of the Molecular Display of Atherosclerotic Lesion Surfaces

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7 January 2021

Mechanistic studies of a peptidic GRP78 ligand for cancer cell-specific drug delivery

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7 January 2021

The role of the unfolded protein response in tumour development: friend or foe?

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7 January 2021

Plasminogen kringle 5 induces apoptosis of brain microvessel endothelial cells: sensitization by radiation and requirement for GRP78 and LRP1.

1 reference

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7 January 2021

Fingerprinting the circulating repertoire of antibodies from cancer patients

1 reference

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7 January 2021

The role of MTJ-1 in cell surface translocation of GRP78, a receptor for alpha 2-macroglobulin-dependent signaling

1 reference

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7 January 2021

Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.

1 reference

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7 January 2021

Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis

1 reference

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7 January 2021

Beyond receptor expression levels: the relevance of target accessibility in ligand-directed pharmacodelivery systems

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7 January 2021

Probing the structural and molecular diversity of tumor vasculature

1 reference

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7 January 2021

Identification of proteins associating with glycosylphosphatidylinositol- anchored T-cadherin on the surface of vascular endothelial cells: role for Grp78/BiP in T-cadherin-dependent cell survival

1 reference

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7 January 2021

Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer

1 reference

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7 January 2021

Getting a GRP on tissue factor activation

1 reference

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7 January 2021

The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Regulation of cancer cell metabolism by hypoxia-inducible factor 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Cancer-selective apoptotic effects of extracellular and intracellular Par-4.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Angiostatin and angiostatin-related proteins

1 reference

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7 January 2021

Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis

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7 January 2021

Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Cancer cell-derived microparticles bearing P-selectin glycoprotein ligand 1 accelerate thrombus formation in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Major histocompatibility class one molecule associates with glucose regulated protein (GRP) 78 on the cell surface

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Overexpression of endoplasmic reticulum molecular chaperone GRP94 and GRP78 in human lung cancer tissues and its significance.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Overexpression of the 78-kDa glucose-regulated protein/immunoglobulin-binding protein (GRP78/BiP) inhibits tissue factor procoagulant activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Apoptosis and tumor resistance conferred by Par-4

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2810%2969006-2

7 January 2021

Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice

1 reference

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7 January 2021

10.1016/S0065-2660(10)69006-2

Identifiers

DOI

1 reference

23 August 2017

1 reference