(Q37838707)

24 August 2017

title

Does inflammation have a role in the pathogenesis of venous ulcers? A critical review of the evidence (English)

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24 August 2017

0 references

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Yen Chen Liu

1

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24 August 2017

David J Margolis

series ordinal

2

1 reference

24 August 2017

R Rivkah Isseroff

series ordinal

3

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24 August 2017

language of work or name

English

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publication date

10 February 2011

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Journal of Investigative Dermatology

24 August 2017

published in

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24 August 2017

volume

131

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24 August 2017

issue

4

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24 August 2017

page(s)

818-827

1 reference

Interleukin-6 concentrations in wound fluids rather than serological markers are useful in assessing bacterial triggers of ulcer inflammation

24 August 2017

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7 January 2021

The dinucleotide (CA) repeat polymorphism of estrogen receptor beta but not the dinucleotide (TA) repeat polymorphism of estrogen receptor alpha is associated with venous ulceration.

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7 January 2021

Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERβ) gene ESR2 are associated with venous ulceration

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7 January 2021

Increased TIMP/MMP ratio in varicose veins: a possible explanation for extracellular matrix accumulation

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Efficacy of topical pale sulfonated shale oil in the treatment of venous leg ulcers: a randomized, controlled, multicenter study

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

The epidemiology of chronic venous insufficiency and varicose veins

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Inflammatory cytokine levels in chronic venous insufficiency ulcer tissue before and after compression therapy

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Multiplexed analysis of matrix metalloproteinases in leg ulcer tissue of patients with chronic venous insufficiency before and after compression therapy

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Quantitative studies on the influence of leukocytes on the vascular resistance in a skeletal muscle preparation.

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

The effect of sustained venous hypertension on the skin capillaries of the canine hind limb

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Pericapillary fibrin in the ulcer-bearing skin of the leg: the cause of lipodermatosclerosis and venous ulceration.

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Regulation of matrix metalloproteinases: an overview

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Tumor necrosis factor-alfa in nonhealing venous leg ulcers.

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Skin damage in chronic venous insufficiency: does an oxygen diffusion barrier really exist?

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Detection of undegraded fibrin and tumor necrosis factor-α in venous leg ulcers

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Daflon 500 mg and venous leg ulcer: new results from a meta-analysis

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Causes of venous ulceration: a new hypothesis.

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Defective extracellular matrix reorganization by chronic wound fibroblasts is associated with alterations in TIMP-1, TIMP-2, and MMP-2 activity

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Effect of healing on the expression of transforming growth factor beta(s) and their receptors in chronic venous leg ulcers

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Etanercept decreases tumor necrosis factor-alpha activity in chronic wound fluid

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Randomized, double-blind, placebo-controlled, dose- ranging study of granulocyte-macrophage colony stimulating factor in patients with chronic venous leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Flavonoid treatment in patients with healed venous ulcer: flow cytometry analysis suggests increased CD11b expression on neutrophil granulocytes in the circulation

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

What can wound fluids tell us about the venous ulcer microenvironment?

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Inflammation in wound repair: molecular and cellular mechanisms

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https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

The "trap" hypothesis of venous ulceration

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

The relationship between cytokine concentrations and wound healing in chronic venous ulceration.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Fibronectin degradation in chronic wounds depends on the relative levels of elastase, alpha1-proteinase inhibitor, and alpha2-macroglobulin

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Cytokine and protease levels in healing and non-healing chronic venous leg ulcers.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Dermal fibroblasts from venous ulcers are unresponsive to the action of transforming growth factor-beta 1

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Lipodermatosclerosis is characterized by elevated expression and activation of matrix metalloproteinases: implications for venous ulcer formation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Plasminogen activation in venous leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Extravasation of macromolecules and possible trapping of transforming growth factor-beta in venous ulceration

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Venous elasticity after treatment with Daflon 500 mg

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Role of "fibrin" cuffs in chronic nonspecific oral ulceration.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Fibroblasts from chronic wounds show altered TGF‐β‐signaling and decreased TGF‐β Type II Receptor expression

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Altered proliferative responses of dermal fibroblasts to TGF-beta1 may contribute to chronic venous stasis ulcer

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Randomised trial of oral aspirin for chronic venous leg ulcers.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

IL-10 and GM-CSF expression and the presence of antigen-presenting cells in chronic venous ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Animal models in wound healing research: do we need more?

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Association between the use of beta-adrenergic receptor agents and the development of venous leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Hormone replacement therapy and prevention of pressure ulcers and venous leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Fibrinolytic abnormalities in two different cutaneous manifestations of venous disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Healing rates and cost efficacy of outpatient compression treatment for leg ulcers associated with venous insufficiency

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

The proliferative capacity of neonatal skin fibroblasts is reduced after exposure to venous ulcer wound fluid: A potential mechanism for senescence in venous ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Effect of collagen turnover and matrix metalloproteinase activity on healing of venous leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Ectopic localization of matrix metalloproteinase-9 in chronic cutaneous wounds

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Expression of elastase and fibrin in venous leg ulcer biopsies: a pilot study of pentoxifylline versus placebo

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

A reduction in serum cytokine levels parallels healing of venous ulcers in patients undergoing compression therapy

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

The Impact of Differential Expression of Extracellular Matrix Metalloproteinase Inducer, Matrix Metalloproteinase-2, Tissue Inhibitor of Matrix Metalloproteinase-2 and PDGF-AA on the Chronicity of Venous Leg Ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

MMP-8 is the predominant collagenase in healing wounds and nonhealing ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Proteolytic activity in leg ulcer exudate

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Morphometric assessment of the dermal microcirculation in patients with chronic venous insufficiency

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Role of leukocyte activation in patients with venous stasis ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Regulation of matrix contraction in chronic venous disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Microcirculation and venous ulcers: a review

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Patients with venous stasis ulceration have increased monocyte-platelet aggregation

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Mitogen-activated protein kinase p38 pathway in venous ulcer fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Randomized trial of topically applied repifermin (recombinant human keratinocyte growth factor-2) to accelerate wound healing in venous ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Endothelial activation in patients with chronic venous disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Leukocyte activity in the microcirculation of the leg in patients with chronic venous disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Evaluation of the nano-oligosaccharide factor lipido-colloid matrix in the local management of venous leg ulcers: results of a randomised, controlled trial

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

bFGF-induced alterations in cellular markers of senescence in growth-rescued fibroblasts from chronic venous ulcer and venous reflux patients

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Plasma elastase in venous disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Effect of oxidised regenerated cellulose/collagen matrix on proteases in wound exudate of patients with chronic venous ulceration

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Specificity of inhibition of matrix metalloproteinase activity by doxycycline: relationship to structure of the enzyme

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Induction of MMP-1, MMP-3 and TIMP-1 in normal dermal fibroblasts by chronic venous leg ulcer wound fluid*

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Leukocyte activation in patients with venous insufficiency

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Prognostic value of markers of collagen remodeling in venous ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

White cell accumulation in dependent legs of patients with venous hypertension: a possible mechanism for trophic changes in the skin.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Cytokines and growth factors in keratinocytes and sweat glands in chronic venous leg ulcers. An immunohistochemical study

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Biochemical analysis of wound fluid from nonhealing and healing chronic leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Effect of chronic wound exudates and MMP-2/-9 inhibitor on angiogenesis in vitro

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Levels of tumor necrosis factor-alpha (TNF-alpha) and soluble TNF receptors in chronic venous leg ulcers--correlations to healing status

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Tumor necrosis factor-alpha gene polymorphism associated with increased susceptibility to venous leg ulceration

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Matrix metalloproteinases, gelatinase and collagenase, in chronic leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Expression of the adhesion molecules ICAM-1, VCAM-1, and E-selectin and their ligands VLA-4 and LFA-1 in chronic venous leg ulcers

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Leukocytes: their role in the etiopathogenesis of skin damage in venous disease

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Wound fluid from chronic leg ulcers contains elevated levels of metalloproteinases MMP-2 and MMP-9.

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Ability of chronic wound fluids to degrade peptide growth factors is associated with increased levels of elastase activity and diminished levels of proteinase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FJID.2010.428

7 January 2021

Identifiers

DOI

10.1038/JID.2010.428

1 reference

24 August 2017

1 reference