(Q37848051)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

review article

1 reference

title

Probing the links between in vitro potency, ADMET and physicochemical parameters (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Matthew Paul Gleeson

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

Anne Hersey

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

author name string

Dino Montanari

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

publication date

1 March 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Drug Discovery

23 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

page(s)

197-208

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nrd3367

23 January 2020

exact match

0 references

cites work

How many drug targets are there?

1 reference

Driving earlier clinical attrition: if you want to find the needle, burn down the haystack. Considerations for biomarker development

21 January 2018

1 reference

A comprehensive listing of bioactivation pathways of organic functional groups

21 January 2018

1 reference

Lessons from the drug discovery of lapatinib, a dual ErbB1/2 tyrosine kinase inhibitor

21 January 2018

1 reference

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

Molecular complexity and its impact on the probability of finding leads for drug discovery

21 January 2018

1 reference

Drug-like properties: guiding principles for design - or chemical prejudice?

21 January 2018

1 reference

Pursuing the leadlikeness concept in pharmaceutical research.

21 January 2018

1 reference

Biological assay challenges from compound solubility: strategies for bioassay optimization

21 January 2018

1 reference

Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits

21 January 2018

1 reference

Avoiding physicochemical artefacts in early ADME-Tox experiments

21 January 2018

1 reference

The influence of drug-like concepts on decision-making in medicinal chemistry.

21 January 2018

1 reference

The evolution of synthetic oral drug properties.

21 January 2018

1 reference

Using the Golden Triangle to optimize clearance and oral absorption

21 January 2018

1 reference

Defining optimum lipophilicity and molecular weight ranges for drug candidates-Molecular weight dependent lower logD limits based on permeability.

21 January 2018

1 reference

Ligand efficiency: a useful metric for lead selection

21 January 2018

1 reference

Is there a difference between leads and drugs? A historical perspective

21 January 2018

1 reference

Fragment-based drug design: how big is too big?

21 January 2018

1 reference

A comparison of physiochemical property profiles of development and marketed oral drugs

21 January 2018

1 reference

Physicochemical property profiles of marketed drugs, clinical candidates and bioactive compounds

21 January 2018

1 reference

Lead-like, drug-like or "Pub-like": how different are they?

21 January 2018

1 reference

Functional group contributions to drug-receptor interactions.

21 January 2018

1 reference

The maximal affinity of ligands

21 January 2018

1 reference

Ligand efficiency indices as guideposts for drug discovery.

21 January 2018

1 reference

An analysis of the binding efficiencies of drugs and their leads in successful drug discovery programs

21 January 2018

1 reference

Predicting protein druggability

21 January 2018

1 reference

The human disease network

21 January 2018

1 reference

Multi-target therapeutics: when the whole is greater than the sum of the parts

21 January 2018

1 reference

Can we rationally design promiscuous drugs?

21 January 2018

1 reference

Fragments, network biology and designing multiple ligands

21 January 2018

1 reference

Components of successful lead generation

21 January 2018

1 reference

Assessment of the blood-brain barrier in CNS drug discovery

21 January 2018

1 reference

Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain.

21 January 2018

1 reference

Receptor occupancy and brain free fraction

21 January 2018

1 reference

21 January 2018

1 reference

Network pharmacology: the next paradigm in drug discovery

21 January 2018

1 reference

Structure and organization of drug-target networks: insights from genomic approaches for drug discovery

21 January 2018

1 reference

A ‘Rule of Three’ for fragment-based lead discovery?

21 January 2018

1 reference

Drug-target residence time and its implications for lead optimization

21 January 2018

1 reference

Can the pharmaceutical industry reduce attrition rates?

21 January 2018

1 reference

Reaching out to collaborators: crowdsourcing for pharmaceutical research.

21 January 2018

1 reference

Trust, but verify: on the importance of chemical structure curation in cheminformatics and QSAR modeling research

21 January 2018

1 reference

The Discovery of Tadalafil: A Novel and Highly Selective PDE5 Inhibitor. 1: 5,6,11,11a-Tetrahydro-1H-imidazo[1‘,5‘:1,6]pyrido[3,4-b]indole-1,3(2H)-dione Analogues

21 January 2018

1 reference

Simple Method of Calculating Octanol/Water Partition Coefficient

21 January 2018

1 reference

21 January 2018

1 reference

How to improve R&D productivity: the pharmaceutical industry's grand challenge

21 January 2018

1 reference

The influence of lead discovery strategies on the properties of drug candidates

31 March 2020

1 reference

31 March 2020

1 reference

Generation of a set of simple, interpretable ADMET rules of thumb

31 March 2020

1 reference

Dependence of molecular properties on proteomic family for marketed oral drugs

31 March 2020

1 reference

Modeling promiscuity based on in vitro safety pharmacology profiling data

31 March 2020

1 reference

Pharmacological promiscuity: dependence on compound properties and target specificity in a set of recent Roche compounds

31 March 2020

1 reference

The influence of target family and functional activity on the physicochemical properties of pre-clinical compounds

31 March 2020

1 reference

Evaluation of human pharmacokinetics, therapeutic dose and exposure predictions using marketed oral drugs

31 March 2020

1 reference

The Design of Leadlike Combinatorial Libraries

31 March 2020

1 reference

12 December 2020

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

12 December 2020

Molecular properties that influence oral drug-like behavior.

1 reference

12 December 2020

Application of pharmaceutical profiling assays for optimization of drug-like properties

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3367

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21358739%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

1 reference