(Q37935600)

25 August 2017

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title

Functions of the APP gene family in the nervous system: insights from mouse models (English)

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25 August 2017

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Dorothee Aydin

1

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25 August 2017

Sascha W Weyer

series ordinal

2

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25 August 2017

Ulrike C Müller

series ordinal

3

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25 August 2017

publication date

20 September 2011

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Experimental Brain Research

25 August 2017

published in

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25 August 2017

volume

217

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25 August 2017

issue

3-4

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25 August 2017

page(s)

423-434

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The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins

25 August 2017

cites work

1 reference

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Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint.

21 January 2018

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Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex

21 January 2018

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Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo

21 January 2018

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A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.

21 January 2018

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ADAM-10 over-expression increases cortical synaptogenesis

21 January 2018

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Signaling by synaptogenic molecules.

21 January 2018

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Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.

21 January 2018

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Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone.

21 January 2018

1 reference

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Identification and expression of the first nonmammalian amyloid-beta precursor-like protein APLP2 in the amphibian Xenopus laevis

21 January 2018

1 reference

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21 January 2018

1 reference

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Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases

21 January 2018

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Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

21 January 2018

1 reference

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Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Amyloid precursor protein is trafficked and secreted via synaptic vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein li

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta-amyloid-precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Multiple roles of calcium ions in the regulation of neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Identification of NEEP21 as a β-Amyloid Precursor Protein-Interacting ProteinIn VivoThat Modulates Amyloidogenic ProcessingIn Vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

A domain level interaction network of amyloid precursor protein and Abeta of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

The X11/Mint family of adaptor proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Homo- and heterodimerization of APP family members promotes intercellular adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

The interactome of the amyloid beta precursor protein family members is shaped by phosphorylation of their intracellular domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

alpha- and beta-secretase: profound changes in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

The APP family of proteins: similarities and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Expression and ultrastructural localization of Mint2 in the spinal cord of rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

The amyloid precursor protein: beyond amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00221-011-2861-2

Levels of alpha- and beta-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients

21 January 2018

1 reference

12 December 2020

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity

1 reference

12 December 2020

Generation of conditional null alleles for APP and APLP2.

1 reference

12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

12 December 2020

Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation

1 reference

12 December 2020

Signaling events regulating the neurodevelopmental triad. Glutamate and secreted forms of beta-amyloid precursor protein as examples

1 reference

12 December 2020

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1 reference

12 December 2020

beta-amyloid precursor protein can be transported independent of any sorting signal to the axonal and dendritic compartment

1 reference

12 December 2020

Distinct expression patterns of two zebrafish homologues of the human APP gene during embryonic development

1 reference

12 December 2020

[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients

1 reference

12 December 2020

Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).

1 reference

12 December 2020

Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42

1 reference

12 December 2020

Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis.

1 reference

12 December 2020

10.1007/S00221-011-2861-2

Identifiers

DOI

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25 August 2017

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