(Q37943853)

25 August 2017

Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook (English)

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25 August 2017

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Warwick B Dunn

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Roy Goodacre

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2

object named as

Royston Goodacre

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25 August 2017

Ludwig Neyses

3

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PubMed ID

21985415

25 August 2017

Mamas Mamas

series ordinal

4

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25 August 2017

1 October 2011

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25 August 2017

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25 August 2017

3

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25 August 2017

2205-2222

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25 August 2017

19

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Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

25 August 2017

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Systematic functional analysis of the yeast genome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolite profiling for plant functional genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Statistical strategies for avoiding false discoveries in metabolomics and related experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolic fingerprinting in disease diagnosis: biomedical applications of infrared and Raman spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Mass spectrometry-based metabolomics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Development of a robust and repeatable UPLC-MS method for the long-term metabolomic study of human serum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Evaluation of the repeatability of ultra-performance liquid chromatography-TOF-MS for global metabolic profiling of human urine samples

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Analytical error reduction using single point calibration for accurate and precise metabolomic phenotyping.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Chemometrics in metabolomics--a review in human disease diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

HMDB: a knowledgebase for the human metabolome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971-1993

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Glucose and insulin abnormalities in patients with heart failure.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Peripheral arterial disease in patients with diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Application of metabolomics to cardiovascular biomarker and pathway discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomics and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Genomics in cardiac metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomic strategies to study lipotoxicity in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Systems biology approaches and pathway tools for investigating cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Biomarkers and surrogate endpoints: preferred definitions and conceptual framework

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

The role of metabolites and metabolomics in clinically applicable biomarkers of disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolite profiles and the risk of developing diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Mechanism of amino acid-induced skeletal muscle insulin resistance in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

The insulin receptor--a critical link in glucose homeostasis and insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Causes of early-onset type 1 diabetes: toward data-driven environmental approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Insulin sensitivity is reflected by characteristic metabolic fingerprints--a Fourier transform mass spectrometric non-targeted metabolomics approach

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomic identification of novel biomarkers of myocardial ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Nuclear magnetic resonance-based metabolomics predicts exercise-induced ischemia in patients with suspected coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Silent myocardial ischemia is associated with altered plasma phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Proton NMR analysis of plasma is a weak predictor of coronary artery disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Plasma metabolomics reveals biomarkers of the atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolites secreted by human atherothrombotic aneurysms revealed through a metabolomic approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

NMR-based metabolomics of urine for the atherosclerotic mouse model using apolipoprotein-E deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabonomics study of atherosclerosis rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabonomic characterization of early atherosclerosis in hamsters with induced cholesterol

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

An obesity-associated gut microbiome with increased capacity for energy harvest

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Improving metabolite knowledge in stable atherosclerosis patients by association and correlation of GC-MS and 1H NMR fingerprints

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomics in angiotensin II-induced cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Proteomic and metabolomic analysis of atrial profibrillatory remodelling in congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

High heritability of metabolomic profiles in families burdened with premature cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomics applied to diabetes research: moving from information to knowledge

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomics as a functional genomic tool for understanding lipid dysfunction in diabetes, obesity and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Current challenges in metabolomics for diabetes research: a vital functional genomic tool or just a ploy for gaining funding?

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Practical analytical approach for the identification of biomarker candidates in prediabetic state based upon metabonomic study by ultraperformance liquid chromatography coupled to electrospray ionization time-of-flight mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Correlative and quantitative 1H NMR-based metabolomics reveals specific metabolic pathway disturbances in diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Quantitative metabolomics by H-NMR and LC-MS/MS confirms altered metabolic pathways in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Beyond glucose: metabolic shifts in responses to the effects of the oral glucose tolerance test and the high-fructose diet in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabonomic identification of novel biomarkers in doxorubicin cardiotoxicity and protective effect of the natural antioxidant oleuropein

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomic approach with LC-QTOF to study the effect of a nutraceutical treatment on urine of diabetic rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Effect of traditional Chinese medicine berberine on type 2 diabetes based on comprehensive metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabonomic study of biochemical changes in the serum of type 2 diabetes mellitus patients after the treatment of metformin hydrochloride

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Leptin therapy in insulin-deficient type I diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabonomic variations in the drug-treated type 2 diabetes mellitus patients and healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

A metabolome pipeline: from concept to data to knowledge

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Development and Performance of a Gas Chromatography−Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Metabolomic strategies to identify tissue-specific effects of cardiovascular drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Global metabolic profiling procedures for urine using UPLC–MS

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FBIO.11.223

21 January 2018

Identifiers

DOI

10.4155/BIO.11.223

1 reference

25 August 2017

1 reference

PubMed ID

21985415