(Q37958069)

25 August 2017

Drug-permeability and transporter assays in Caco-2 and MDCK cell lines (English)

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25 August 2017

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Donna A Volpe

1

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25 August 2017

1 December 2011

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Future Medicinal Chemistry

25 August 2017

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25 August 2017

3

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25 August 2017

2063-2077

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25 August 2017

16

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Current industrial practices of assessing permeability and P-glycoprotein interaction

25 August 2017

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Mitigating permeability-mediated risks in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Recent advances in high throughput screening for ADME properties

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.11.149

Comprehensive assessment of ADMET risks in drug discovery

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.11.149

Intestinal permeability and its relevance for absorption and elimination

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Membrane transporters in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Biopharmaceutics classification system: validation and learnings of an in vitro permeability assay

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Towards prediction of in vivo intestinal absorption using a 96-well Caco-2 assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Prediction of the in vitro permeability determined in Caco-2 cells by using artificial neural networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Drug permeation across intestinal epithelial cells using porous silicon nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Absorption of poorly water soluble drugs subject to apical efflux using phospholipids as solubilizers in the Caco-2 cell model

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

In vitro permeability enhancement in intestinal epithelial cells (Caco-2) monolayer of water soluble quaternary ammonium chitosan derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Ibuprofen is a non-competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

pH-Dependent passive and active transport of acidic drugs across Caco-2 cell monolayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Prediction of human intestinal first-pass metabolism of 25 CYP3A substrates from in vitro clearance and permeability data.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

In vitro interactions between aged garlic extract and drugs used for the treatment of cardiovascular and diabetic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Effects of capsaicin on P-gp function and expression in Caco-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Application and limitation of inhibitors in drug-transporter interactions studies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Variability in Caco-2 and MDCK cell-based intestinal permeability assays

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Application of method suitability for drug permeability classification

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Evaluation of cocktail approach to standardise Caco-2 permeability experiments.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Epithelial cells in culture as a model for the intestinal transport of antimicrobial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Why we should be vigilant: drug cytotoxicity observed with in vitro transporter inhibition studies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

The biological and clinical role of drug transporters at the intestinal barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Monocarboxylate transporter-mediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Expression levels of human P-glycoprotein in in vitro cell lines: correlation between mRNA and protein levels for P-glycoprotein expressed in cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Peptide transporter substrate identification during permeability screening in drug discovery: comparison of transfected MDCK-hPepT1 cells to Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

pH dependence of organic anion-transporting polypeptide 2B1 in Caco-2 cells: potential role in antiretroviral drug oral bioavailability and drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Culture period-dependent change of function and expression of ATP-binding cassette transporters in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Transepithelial secretion, cellular accumulation and cytotoxicity of vinblastine in defined MDCK cell strains

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Differences in the expression of endogenous efflux transporters in MDR1-transfected versus wildtype cell lines affect P-glycoprotein mediated drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

P-gp inhibition potential in cell-based models: which "calculation" method is the most accurate?

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Permeability classification of representative fluoroquinolones by a cell culture method

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Avermectin transepithelial transport in MDR1- and MRP-transfected canine kidney monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

A Caco-2 cell based screening method for compounds interacting with MRP2 efflux protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Compound profiling for ABCC2 (MRP2) using a fluorescent microplate assay system

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

A 96-well efflux assay to identify ABCG2 substrates using a stably transfected MDCK II cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Effects of polyoxyethylene (40) stearate on the activity of P-glycoprotein and cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Synthesis and in vitro evaluation of gabapentin prodrugs that target the human apical sodium-dependent bile acid transporter (hASBT).

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Synthesis and in vitro evaluation of potential sustained release prodrugs via targeting ASBT

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Comparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: relevance to in vivo prediction.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Inhibition of P-glycoprotein-mediated efflux of digoxin and its metabolites by macrolide antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Estimation of ADME properties in drug discovery: predicting Caco-2 cell permeability using atom-based stochastic and non-stochastic linear indices

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Evaluation of a generic physiologically based pharmacokinetic model for lineshape analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Evaluation of drug transporter interactions in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Establishment and characterization of Mardin-Darby canine kidney cells stably expressing human organic anion transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Comparison of in vitro cell models in predicting in vivo brain entry of drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

Fraction of a dose absorbed estimation for structurally diverse low solubility compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.11.149

21 January 2018

Identifiers

DOI

10.4155/FMC.11.149

1 reference

25 August 2017

1 reference

PubMed ID

22098353